Neuroprotective effect of physical exercise in a depression model in rodents: a meta-analysis
DOI:
https://doi.org/10.34024/rnc.2023.v31.14734Keywords:
Neuroprotection, Physical exercise, Depression, Nursing, Mental Health CareAbstract
Introduction. Studies in the neurobiology of depression show a dysregulation of neurotransmitters in brain regions related to emotion, reward and executive functions in individuals affected by the disease. The regular practice of physical exercise is shown as an important ally against depression. Method. It was searched through a systematic review, bibliographic material from 2010 to 2021 that described the neuroprotective effect of physical exercise in the treatment of depression. We use the descriptors: Depression, Neuroprotective and Physical Exercise in the databases PubMed, LILACS, Science Direct, Web of Science and SCIELO. Results. 04 articles were selected. Regular physical exercise promotes neurophysiological and neurochemical changes capable of influencing the disease, with BDNF and IGF-1 being highlighted as pro neurogenic factors and biochemical changes, added to changes in the HPP axis during the treatment of depression. It is noteworthy that the training period was crucial for the neuroprotective effect. Such evidence configures physical exercise as an excellent ally in the treatment of depression, especially mild depression. Conclusion. It’s suggested research with a duration of 09 weeks of the physical training protocol. We encourage further research into the complex inflammation-induced effects of exercise. Furthermore, we can infer that the study could have different results if the time for analysis of this neuroprotection were extended or LPS monitoring was added to control LPS levels x Exercise time x improvement in depressive condition.
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Copyright (c) 2023 Maria Jussara Medeiros Nunes, Paloma Katlheen Moura Melo, Marcília Ingrid Lima Barroso Nunes, Jean Carlos Souza Silva, Antônio William do Nascimento Fernandes, Anne Itamara Benigna Evangelista, Ivana Alice Teixeira Fonseca, Dayane Pessoa de Araújo
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