Exposure to glyphosate and neurological changes - a bibliographic review
DOI:
https://doi.org/10.34024/rnc.2024.v32.15902Keywords:
Central Nervous System, Brain, Glyphosate, AgrochemicalAbstract
Introduction. The need to maximize productivity with a view to greater profitability has led to the pressing need to use mechanisms to maximize agricultural production. In this context, agrochemicals have reached new heights and are now used in an unbridled manner. Exposure to agrochemicals is correlated with a variety of injuries, whether in the animal or plant kingdom. Glyphosate, a powerful herbicide responsible for removing weeds from plants, has been widely correlated with various pathologies, and more recently it has been observed that it has the ability to cross the hematopoietic barrier and thus cause alterations to the structures of the nervous system. Objective. To review the existing literature outlining the damage caused to neurological tissue by exposure to glyphosate. Method. A systematic search was carried out in the PubMed, Science Direct and Medline databases, using the descriptors ''Brain'' OR ''Central Nervous System'' AND ''Glyphosate'' AND "Agrochemical". Original primary studies published between 2018 and 2023 were included. Articles that did not include the subject proposed for the study in the scope of the text were excluded. Results. The subject still needs further study, however, given the scientific evidence available, it is possible to infer that there is a direct and indirect correlation of injury to various structures of the nervous system. Conclusion. Neurological manifestations occurred frequently during the course of exposure
Downloads
References
Reyna EF, Braga MJ, Morais GAS. Impactos do uso de agrotóxicos sobre a eficiência técnica na agricultura brasileira. In: Vieira Filho JER, Gasques JG (org). Uma jornada pelos contrastes do Brasil : cem anos do Censo Agropecuário. Brasília: Ipea; 2020; p173-87. http://doi.org/10.38116/978-65-5635-011-0/cap12
Moraes RF. Agrotóxicos no Brasil: padrões de uso, política da regulação e prevenção da captura regulatória. Brasília: Ipea; 2019; p76. http://repositorio.ipea.gov.br/bitstream/11058/9371/1/td_2506.pdf
Lopes CVA, Albuquerque GSC. Agrotóxicos e seus impactos na saúde humana e ambiental: uma revisão sistemática. Saúde em Debate 2018;42:518-34. https://doi.org/10.1590/0103-1104201811714
Soares D, Silva L, Duarte S, Pena A, Pereira A. Glyphosate use, toxicity and occurrence in food. Foods 2021;10:1-22. https://doi.org/10.3390/foods10112785
Peillex C, Pelletier M. The impact and toxicity of glyphosate and glyphosate-based herbicides on health and immunity. J Immunotoxicol 2020;17:163-74. https://doi.org/10.1080/1547691X.2020.1804492
Muller YMR. Hepatotoxicidade do herbicida a base de glifosato, utilizando Danio rerio como modelo experimental (Tese). Florianópolis: Universidade Federal de Santa Catarina; 2021. https://repositorio.ufsc.br/handle/123456789/231007
Connolly A, Jones K, Basinas I, Galea KS, Kenny L, McGowan P, et al. Exploring the half-life of glyphosate in human urine samples. Int J Hyg Environ Health 2019;222:205-10. https://doi.org/10.1016/j.ijheh.2018.09.004
ANVISA. Programa de análise de resíduos de agrotóxico em alimentos - PARA. Resultados do 1º. ciclo 2017-2020. https://www.gov.br/anvisa/pt-br/assuntos/agrotoxicos/programa-de-analise-de-residuos-em-alimentos/arquivos/3772json-file-1
ANVISA. Parecer no 4/2018 Apreciação e encaminhamento para a Diretoria relatora (DIARE) da proposta final de RDC que dispõe sobre os critérios e os procedimentos para reavaliação toxicológica de ingredientes ativos de agrotóxicos no âmbito da Anvisa, com as alterações sugeridas pela Procuradoria. https://antigo.anvisa.gov.br/documents/10181/2859776/Despacho+n%C2%BA+4-2018-GGTOX+-+Encaminhamento+de+proposta+final+de+RDC+p%C3%B3s+procuradoria+-+CP+313-2017/16955688-1202-4dc9-9b23-32b967416e24?version=1.0
Araújo EC. Frota brasileira de aeronaves agrícolas – 2020. https://sindag.org.br/wp-content/uploads/2021/05/frota-2020-versao-2.pdf
Milesi MM, Lorenz V, Durando M, Rossetti MF, Varayoud J. Glyphosate Herbicide: Reproductive Outcomes and Multigenerational Effects. Front Endocrinol 2021;12:672532. https://doi.org/10.3389/fendo.2021.672532
Kwiatkowska M, Jarosiewicz P, Bukowska B. Glyphosate and its formulations - toxicity, occupational and environmental exposure. Med Pr 2013;64:717-29. https://doi.org/10.13075/mp.5893.2013.0059
Baek Y, Bobadilla LK, Giacomini DA, Montgomery JS, Murphy BP, Tranel PJ. Evolution of Glyphosate-Resistant Weeds. In: Knaak JB (eds). Reviews of Environmental Contamination and Toxicology Volume 255. Springer, Cham; 2021. https://doi.org/10.1007/398_2020_55
Cosemans C, Van Larebeke N, Janssen BG, Martens DS, Baeyens W, Bruckers L, et al. Glyphosate and AMPA exposure in relation to markers of biological aging in an adult population-based study. Int J Hyg Environ Health 2022;240:113895. https://doi.org/10.1016/j.ijheh.2021.113895
Gomes do Nascimento J, Almeida WS. Alterações no sistema nervoso em decorrência de contaminação por SARS-COV-2: revisão sistemática. Rev Neurocienc 2023;31:1-11. https://doi.org/10.34024/rnc.2023.v31.15458
Mostafalou S, Abdollahi M. The susceptibility of humans to neurodegenerative and neurodevelopmental toxicities caused by organophosphorus pesticides. Arch Toxicol 2023;97:3037-60. https://doi.org/10.1016/j.cca.2003.110022
Cattani D, Pierozan P, Zamoner A, Brittebo E, Karlsson O. Long-Term Effects of Perinatal Exposure to a Glyphosate-Based Herbicide on Melatonin Levels and Oxidative Brain Damage in Adult Male Rats. Antioxidants 2023;12:1825. https://doi.org/10.3390/antiox12101825
Matsuzaki R, Gunnigle E, Geissen V, Clarke G, Nagpal J, Cryan JF. Pesticide exposure and the microbiota-gut-brain axis. ISME J 2023;17:1153-66. https://doi.org/10.1038/s41396-023-01450-9
Zhang D, Ding W, Liu W, Li L, Zhu G, Ma J. Single and Combined Effects of Chlorpyrifos and Glyphosate on the Brain of Common Carp: Based on Biochemical and Molecular Perspective. Int J Mol Sci 2023;24:12934. https://doi.org/10.3390/ijms241612934
Dechartres J, Pawluski JL, Gueguen M, Jablaoui A, Maguin E, Rhimi M, et al. Glyphosate and glyphosate‐based herbicide exposure during the peripartum period affects maternal brain plasticity, maternal behaviour and microbiome. J Neuroendocrinol 2019;31:e12731. https://doi.org/10.1111/jne.12731
Anderson G. Amyotrophic Lateral Sclerosis Pathoetiology and Pathophysiology: Roles of Astrocytes, Gut Microbiome, and Muscle Interactions via the Mitochondrial Melatonergic Pathway, with Disruption by Glyphosate-Based Herbicides. Int J Mol Sci 2022;24:587. https://doi.org/10.3390/ijms24010587
Duque-Díaz E, Hurtado Giraldo H, Rocha-Muñoz LP, Coveñas R. Glyphosate, AMPA and glyphosate-based herbicide exposure leads to GFAP, PCNA and caspase-3 increased immunoreactive area on male offspring rat hypothalamus. Eur J Histochem 2022;66:3428. https://doi.org/10.4081/ejh.2022.3428
Ait-Bali Y, Ba-M’hamed S, Gambarotta G, Sassoè-Pognetto M, Giustetto M, Bennis M. Pre- and postnatal exposure to glyphosate-based herbicide causes behavioral and cognitive impairments in adult mice: evidence of cortical ad hippocampal dysfunction. Arch Toxicol 2020;94:1703-23. https://doi.org/10.1007/s00204-020-02677-7
Cattani D, Cesconetto PA, Tavares MK, Parisotto EB, De Oliveira PA, Rieg CEH, et al. Developmental exposure to glyphosate-based herbicide and depressive-like behavior in adult offspring: Implication of glutamate excitotoxicity and oxidative stress. Toxicology 2017;387:67-80. https://doi.org/10.1016/j.tox.2017.06.001
Gallegos CE, Bartos M, Bras C, Gumilar F, Antonelli MC, Minetti A. Exposure to a glyphosate-based herbicide during pregnancy and lactation induces neurobehavioral alterations in rat offspring. Neurotoxicology 2016;53:20-8. https://doi.org/10.1016/j.neuro.2015.11.015
Oummadi A, Menuet A, Méresse S, Laugeray A, Guillemin G, Mortaud S. The herbicides glyphosate and glufosinate and the cyanotoxin β-N-methylamino-l-alanine induce long-term motor disorders following postnatal exposure: the importance of prior asymptomatic maternal inflammatory sensitization. Front Neurosci 2023;17:1172693. https://doi.org/10.3389/fnins.2023.1172693/full
Izumi Y, O’Dell KA, Zorumski CF. The herbicide glyphosate inhibits hippocampal long-term potentiation and learning through activation of pro-inflammatory signaling. Sci Rep 2023;13:18005. https://doi.org/10.1038/s41598-023-44121-7
Ojiro R, Okano H, Takahashi Y, Takashima K, Tang Q, Ozawa S, et al. Comparison of the effect of glyphosate and glyphosate-based herbicide on hippocampal neurogenesis after developmental exposure in rats. Toxicology 2023;483:153369. https://doi.org/10.1016/j.tox.2022.153369
Coullery RP, Ferrari ME, Rosso SB. Neuronal development and axon growth are altered by glyphosate through a WNT non-canonical signaling pathway. Neurotoxicology 2016;52:150-61. https://doi.org/10.1016/j.neuro.2015.12.004
Coullery R, Pacchioni AM, Rosso SB. Exposure to glyphosate during pregnancy induces neurobehavioral alterations and downregulation of Wnt5a-CaMKII pathway. Reprod Toxicol 2020;96:390-8. https://doi.org/10.1016/j.reprotox.2020.08.006
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Jorge Gomes do Nascimento, Willian Serra de Almeida
This work is licensed under a Creative Commons Attribution 4.0 International License.
Português
English
Español
