Achados neuropatológicos da Covid-19: uma revisão sistemática

Autores

DOI:

https://doi.org/10.34024/rnc.2021.v29.11842

Palavras-chave:

Covid-19, Coronavírus, Neuroinflamação, Acidente Vascular Cerebral

Resumo

Introdução. A doença causada pelo Sars-Cov-2, Covid-19, foi identificada pela primeira vez na China e apresentou rápida expansão mundial, sendo reconhecida como pandemia em março de 2020. Apesar de causar uma infecção de vias aéreas, descobertas clínicas recentes e estudos com animais sugerem que o vírus também promove vias neuronais notáveis e comprometimentos do sistema circulatório, levando a lesões no sistema nervoso central. Objetivo. Coletar e analisar os dados publicados entre 2019 e 2020 a respeito de lesões encontradas no sistema nervoso a partir de estudos de necrópsia e de imagem realizados em seres humanos. Método. Uma busca sistemática foi feita nas bases de dados PubMed e Science Direct utilizando os descritores “COVID-19” OU “SARS-CoV-2” OU “Coronavirus” AND “Central Nervous System” OU “Brain” AND “Autopsy” OR “RMI”. Foram incluídos estudos originais primários, publicados entre 2019 e 2020. Foram excluídos estudos realizados em animais, casos não comprovados de contaminação por COVID-19 e estudos in vitro. Resultados. Os principais achados desta revisão sistemática apontam para causas imunológicas, inflamatórias e infecciosas. Hemorragia intracranial e intracerebral e Acidente Vascular Cerebral (AVC) isquêmico foram os principais eventos relatados, sendo que o AVC relacionado a Covid-19 tende a ser mais grave do que outras causas. Conclusão. Embora os dados científicos ainda sejam escassos para explicar as vias de dano do SARS-CoV-2 no sistema nervoso central, as evidências disponíveis sugerem uma correlação entre COVID-19 e complicações neurológicas em alguns pacientes.

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Publicado

2021-10-06

Como Citar

Ferreira, Q. R. ., Costa, B. T. da, Mendes, M. M., Cavalcanti, V. N., Santos, A. C. L., Araújo, D. M. P., & Oliveira, P. da S. (2021). Achados neuropatológicos da Covid-19: uma revisão sistemática. Revista Neurociências, 29, 1–20. https://doi.org/10.34024/rnc.2021.v29.11842

Edição

Seção

Revisão Sistemática
Recebido em 2021-03-04
Aceito em 2021-09-13
Publicado em 2021-10-06