Alterações no sistema nervoso em decorrência de contaminação por SARS-COV-2: revisão sistemática
DOI:
https://doi.org/10.34024/rnc.2023.v31.15458Palavras-chave:
Sistema Nervoso, Manifestações Neurológicas, SARS-CoV-2, COVID-19Resumo
Introdução. O Vírus SARS-CoV-2, causador do COVID 19, tem a capacidade de infectar os seres humanos, atingindo uma vasta gama de células e tecidos. Destacando sua predileção para o sistema respiratório, atingindo também o Sistema Nervoso. Pesquisas têm demonstrado sequelas neurológicas em pacientes contaminados por COVID-19. Objetivo. Revisar a bibliografia existente que delineiam as injurias causadas por COVID-19 ao tecido neurológico. Método. A pesquisa fundamentou seus dados por meio de busca em bancos de dados. Foi usado como filtros de pesquisa; título, assunto e tipo. O descritor Neurological foi associado utilizando o operador booleano AND com os descritores: Coronavirus COVID-19 e Nervous System e seus respectivos correspondentes em português. Resultados. Assim como os demais tipos de corona vírus, o Sars-cov-2 possui capacidade de neuroinvasiva. A sintomatologia, pode sofrer variações ponde essa ser leves ou graves predispondo a aparição de agravos cerebrovascular, com predominância em pacientes com comorbidades pré-existentes. O período de manifestação dos sintomas pode ocorrer em média de um a 2 dias após aparecimento dos sintomas respiratórios. Conclusão. Este estudo apresenta novos e importantes subsídios a respeito da COVID-19 e as alterações ao tecido do sistema nervoso fomentando subsídio aos profissionais da área da saúde em ampliar a perspectiva da doença além dos distúrbios cardiorrespiratórios, evidenciando o progresso clínico da doença para manifestações neurológicas associadas.
Downloads
Métricas
Referências
Needham EJ, Chou SHY, Coles AJ, Menon DK. Neurological Implications of COVID-19 Infections. Neurocritical Care 2020;32:667-71. http://doi.org/10.1007/s12028-020-00978-4
Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms. ACS Chem Neurosci 2020;11:995-8. https://doi.org/10.1021/acschemneuro.0c00122
Tay MZ, Poh CM, Rénia L, MacAry PA, Ng LFP. The trinity of COVID-19: immunity, inflammation and intervention. Nat Rev Immunol 2020;20:363-74. http://doi.org/10.1038/s41577-020-0311-8
Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, et al. The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application. Ann Intern Med 2020;172:577-82. https://doi.org/10.7326/M20-0504
Das G, Mukherjee N, Ghosh S. Neurological Insights of COVID-19 Pandemic. ACS Chem Neurosci 2020;11:1206-9. https://doi.org/10.1021/acschemneuro.0c00201
Pallanti S. Importance of SARs-Cov-2 anosmia: From phenomenology to neurobiology. Compr Psychiatry 2020;100:152184. https://doi.org/10.1016/j.comppsych.2020.152184
Heneka MT, Golenbock D, Latz E, Morgan D, Brown R. Immediate and long-term consequences of COVID-19 infections for the development of neurological disease. Alzheimers Res Ther 2020;12:69.https://doi.org/10.1186/s13195-020-00640-3
Felsenstein S, Herbert JA, McNamara PS, Hedrich CM. COVID-19: Immunology and treatment options. Clin Immunol 2020;215:108448. https://doi.org/10.1016/j.clim.2020.108448
Tsivgoulis G, Palaiodimou L, Katsanos AH, Caso V, Köhrmann M, Molina C, et al. Neurological manifestations and implications of COVID-19 pandemic. Ther Adv Neurol Disord 2020;13:175628642093203. https://doi.org/10.1177/1756286420932036
Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 2020;77:683-90. https://doi.org/10.1001/jamaneurol.2020.1127
Conklin J, Frosch MP, Mukerji S, Rapalino O, Maher M, Schaefer PW, et al. Cerebral Microvascular Injury in Severe COVID-19. MedRxiv 2020;2020.07.21.20159376.https://doi.org/10.1101/2020.07.21.20159376
Helms J, Kremer S, Merdji H, Clere-Jehl R, Schenck M, Kummerlen C, et al. Neurologic Features in Severe SARS-CoV-2 Infection. N Engl J Med 2020;382:2268-70. https://doi.org/10.1056/NEJMc2008597
Andersen KG, Rambaut A, Lipkin WI, Holmes EC, Garry RF. The proximal origin of SARS-CoV-2. Nat Med 2020;26:450-2. http://doi.org/10.1038/s41591-020-0820-9
Tunç A, Ünlübaş Y, Alemdar M, Akyüz E. Coexistence of COVID-19 and acute ischemic stroke report of four cases. J Clin Neurosci 2020;77:227-9. https://doi.org/10.1016/j.jocn.2020.05.018
Yu F, Du L, Ojcius DM, Pan C, Jiang S. Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China. Microbes Infect 2020;22:74-9. https://doi.org/10.1016/j.micinf.2020.01.003
Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med 2020;8:420-2. https://doi.org/10.1016/S2213-2600(20)30076-X
Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 2020;395:565-74. http://doi.org/10.1016/S0140-6736(20)30251-8
Wu Y, Xu X, Chen Z, Duan J, Hashimoto K, Yang L, et al. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun 2020;87:18-22. http://doi.org/10.1016/j.bbi.2020.03.031
Biadsee A, Biadsee A, Kassem F, Dagan O, Masarwa S, Ormianer Z. Olfactory and Oral Manifestations of COVID‐19: Sex‐Related Symptoms—A Potential Pathway to Early Diagnosis. Otolaryngol Neck Surg 2020;163:722-8. https://doi.org/10.1177/0194599820934380
Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. J Med Virol 2020;92:552-5. https://doi.org/10.1002/jmv.25728
Baig AM. Neurological manifestations in COVID-19 caused by SARS-CoV-2. CNS Neurosci Ther 2020;26:499-501. https://doi.org/10.1021/acschemneuro.0c00174
Kantonen J, Mahzabin S, Mäyränpää MI, Tynninen O, Paetau A, Andersson N, et al. Neuropathologic features of four autopsied COVID-19 patients. Brain Pathol 2020;0:1-5. https://doi.org/10.1111/bpa.12889
Zayet S, Abdallah YB, Royer PY, Toko-Tchiundzie L, Gendrin V, Klopfenstein T. Encephalopathy in patients with COVID-19: 'Causality or coincidence?' J Med Virol 2020;93:1193. https://doi.org/10.1002/jmv.26027
Sousa CMS, Sousa AAS, Gurgel LC, Brito EAS, Sousa FRS, Santana WJ, et al. Contribuição da atividade física para a qualidade de vida dos idosos: Uma Revisão Integrativa da Literatura. Rev Psicol 2019;13:425-33. https://doi.org/10.14295/idonline.v13i46.1891
Tian S, Xiong Y, Liu H, Niu L, Guo J, Liao M, et al. Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies. Mod Pathol 2020;33:1007-14. https://doi.org/10.1038/s41379-020-0536-x
Yan B, Sun Y, Fu K, Zhang Y, Lei L, Men J, et al. Effects of glyphosate exposure on gut–liver axis: Metabolomic and mechanistic analysis in grass carp (Ctenopharyngodon idellus). Sci Total Environ 2023;902:166062. https://doi.org/10.1016/j.scitotenv.2023.166062
Poyiadji N, Shahin G, Noujaim D, Stone M, Patel S, Griffith B. COVID-19–associated Acute Hemorrhagic Necrotizing Encephalopathy: Imaging Features. Radiology 2020;296:E119-20. http://doi.org/10.1148/radiol.2020201187
Toljan K. Letter to the Editor Regarding the Viewpoint “Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanism.” ACS Chem Neurosci 2020;11:1192-4. https://doi.org/10.1021/acschemneuro.0c00174
Tsai LK, Hsieh ST, Chao CC, Chen YC, Lin YH, Chang SC, et al. Neuromuscular disorders in severe acute respiratory syndrome. Arch Neurol 2004;61:1669-73. https://doi.org/10.1001/archneur.61.11.1669
Liguori C, Pierantozzi M, Spanetta M, Sarmati L, Cesta N, Iannetta M, et al. Subjective neurological symptoms frequently occur in patients with SARS-CoV2 infection. Brain Behav Immun 2020;88:11-6. https://doi.org/10.1016/j.bbi.2020.05.037
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2023 Jorge Gomes do Nascimento, Willian Serra de Almeida

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Aceito: 2023-10-05
Publicado: 2023-10-30