Changes in the nervous system due to SARS-COV-2 contamination: systematic review

Authors

DOI:

https://doi.org/10.34024/rnc.2023.v31.15458

Keywords:

Nervous System, Neurological Manifestations, SARS-CoV-2, COVID-19

Abstract

Introduction. The SARS-CoV-2 Virus, cause of COVID 19, has the ability to infect humans, reaching a wide range of cells and tissues. Highlighting its predilection for the respiratory system, also reaching the Nervous System. Research has demonstrated neurological sequelae in patients infected with COVID-19. Objective. To review the existing literature that outlines the injuries caused by COVID-19 to neurological tissue. Method: The research substantiated its data through a search in databases. It was used as search filters; title, subject and type. The Neurological descriptor was associated using the Boolean AND operator with the descriptors: Coronavirus COVID-19 and Nervous System and their respective correspondents in Portuguese. Results. Like other types of corona virus, Sars-cov-2 has neuroinvasive capacity. The symptomatology may vary depending on whether it is mild or severe, predisposing to the appearance of cerebrovascular disorders, predominantly in patients with pre-existing comorbidities. The period of manifestation of symptoms can occur on average 1 to 2 days after the appearance of respiratory symptoms. Conclusion. This study presents new and important subsidies regarding COVID-19 and changes to the nervous system tissue, encouraging health professionals to broaden the perspective of the disease beyond cardiorespiratory disorders, evidencing the clinical progress of the disease for associated neurological manifestations.

Metrics

Metrics Loading ...

References

Needham EJ, Chou SHY, Coles AJ, Menon DK. Neurological Implications of COVID-19 Infections. Neurocritical Care 2020;32:667-71. http://doi.org/10.1007/s12028-020-00978-4

Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms. ACS Chem Neurosci 2020;11:995-8. https://doi.org/10.1021/acschemneuro.0c00122

Tay MZ, Poh CM, Rénia L, MacAry PA, Ng LFP. The trinity of COVID-19: immunity, inflammation and intervention. Nat Rev Immunol 2020;20:363-74. http://doi.org/10.1038/s41577-020-0311-8

Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, et al. The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application. Ann Intern Med 2020;172:577-82. https://doi.org/10.7326/M20-0504

Das G, Mukherjee N, Ghosh S. Neurological Insights of COVID-19 Pandemic. ACS Chem Neurosci 2020;11:1206-9. https://doi.org/10.1021/acschemneuro.0c00201

Pallanti S. Importance of SARs-Cov-2 anosmia: From phenomenology to neurobiology. Compr Psychiatry 2020;100:152184. https://doi.org/10.1016/j.comppsych.2020.152184

Heneka MT, Golenbock D, Latz E, Morgan D, Brown R. Immediate and long-term consequences of COVID-19 infections for the development of neurological disease. Alzheimers Res Ther 2020;12:69.https://doi.org/10.1186/s13195-020-00640-3

Felsenstein S, Herbert JA, McNamara PS, Hedrich CM. COVID-19: Immunology and treatment options. Clin Immunol 2020;215:108448. https://doi.org/10.1016/j.clim.2020.108448

Tsivgoulis G, Palaiodimou L, Katsanos AH, Caso V, Köhrmann M, Molina C, et al. Neurological manifestations and implications of COVID-19 pandemic. Ther Adv Neurol Disord 2020;13:175628642093203. https://doi.org/10.1177/1756286420932036

Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 2020;77:683-90. https://doi.org/10.1001/jamaneurol.2020.1127

Conklin J, Frosch MP, Mukerji S, Rapalino O, Maher M, Schaefer PW, et al. Cerebral Microvascular Injury in Severe COVID-19. MedRxiv 2020;2020.07.21.20159376.https://doi.org/10.1101/2020.07.21.20159376

Helms J, Kremer S, Merdji H, Clere-Jehl R, Schenck M, Kummerlen C, et al. Neurologic Features in Severe SARS-CoV-2 Infection. N Engl J Med 2020;382:2268-70. https://doi.org/10.1056/NEJMc2008597

Andersen KG, Rambaut A, Lipkin WI, Holmes EC, Garry RF. The proximal origin of SARS-CoV-2. Nat Med 2020;26:450-2. http://doi.org/10.1038/s41591-020-0820-9

Tunç A, Ünlübaş Y, Alemdar M, Akyüz E. Coexistence of COVID-19 and acute ischemic stroke report of four cases. J Clin Neurosci 2020;77:227-9. https://doi.org/10.1016/j.jocn.2020.05.018

Yu F, Du L, Ojcius DM, Pan C, Jiang S. Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China. Microbes Infect 2020;22:74-9. https://doi.org/10.1016/j.micinf.2020.01.003

Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med 2020;8:420-2. https://doi.org/10.1016/S2213-2600(20)30076-X

Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 2020;395:565-74. http://doi.org/10.1016/S0140-6736(20)30251-8

Wu Y, Xu X, Chen Z, Duan J, Hashimoto K, Yang L, et al. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun 2020;87:18-22. http://doi.org/10.1016/j.bbi.2020.03.031

Biadsee A, Biadsee A, Kassem F, Dagan O, Masarwa S, Ormianer Z. Olfactory and Oral Manifestations of COVID‐19: Sex‐Related Symptoms—A Potential Pathway to Early Diagnosis. Otolaryngol Neck Surg 2020;163:722-8. https://doi.org/10.1177/0194599820934380

Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. J Med Virol 2020;92:552-5. https://doi.org/10.1002/jmv.25728

Baig AM. Neurological manifestations in COVID-19 caused by SARS-CoV-2. CNS Neurosci Ther 2020;26:499-501. https://doi.org/10.1021/acschemneuro.0c00174

Kantonen J, Mahzabin S, Mäyränpää MI, Tynninen O, Paetau A, Andersson N, et al. Neuropathologic features of four autopsied COVID-19 patients. Brain Pathol 2020;0:1-5. https://doi.org/10.1111/bpa.12889

Zayet S, Abdallah YB, Royer PY, Toko-Tchiundzie L, Gendrin V, Klopfenstein T. Encephalopathy in patients with COVID-19: 'Causality or coincidence?' J Med Virol 2020;93:1193. https://doi.org/10.1002/jmv.26027

Sousa CMS, Sousa AAS, Gurgel LC, Brito EAS, Sousa FRS, Santana WJ, et al. Contribuição da atividade física para a qualidade de vida dos idosos: Uma Revisão Integrativa da Literatura. Rev Psicol 2019;13:425-33. https://doi.org/10.14295/idonline.v13i46.1891

Tian S, Xiong Y, Liu H, Niu L, Guo J, Liao M, et al. Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies. Mod Pathol 2020;33:1007-14. https://doi.org/10.1038/s41379-020-0536-x

Yan B, Sun Y, Fu K, Zhang Y, Lei L, Men J, et al. Effects of glyphosate exposure on gut–liver axis: Metabolomic and mechanistic analysis in grass carp (Ctenopharyngodon idellus). Sci Total Environ 2023;902:166062. https://doi.org/10.1016/j.scitotenv.2023.166062

Poyiadji N, Shahin G, Noujaim D, Stone M, Patel S, Griffith B. COVID-19–associated Acute Hemorrhagic Necrotizing Encephalopathy: Imaging Features. Radiology 2020;296:E119-20. http://doi.org/10.1148/radiol.2020201187

Toljan K. Letter to the Editor Regarding the Viewpoint “Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanism.” ACS Chem Neurosci 2020;11:1192-4. https://doi.org/10.1021/acschemneuro.0c00174

Tsai LK, Hsieh ST, Chao CC, Chen YC, Lin YH, Chang SC, et al. Neuromuscular disorders in severe acute respiratory syndrome. Arch Neurol 2004;61:1669-73. https://doi.org/10.1001/archneur.61.11.1669

Liguori C, Pierantozzi M, Spanetta M, Sarmati L, Cesta N, Iannetta M, et al. Subjective neurological symptoms frequently occur in patients with SARS-CoV2 infection. Brain Behav Immun 2020;88:11-6. https://doi.org/10.1016/j.bbi.2020.05.037

Published

2023-10-30

Issue

Section

Artigos de Revisão

How to Cite

1.
Gomes do Nascimento J, Almeida WS de. Changes in the nervous system due to SARS-COV-2 contamination: systematic review. Rev Neurocienc [Internet]. 2023 Oct. 30 [cited 2025 Dec. 13];31:1-11. Available from: https://periodicos.unifesp.br/index.php/neurociencias/article/view/15458
Received 2023-07-31
Accepted 2023-10-05
Published 2023-10-30