Efeito neuroprotetor do exercício físico em modelos de depressão em roedores: uma meta-análise
DOI:
https://doi.org/10.34024/rnc.2023.v31.14734Palavras-chave:
Neuroproteção, Exercício físico, Depressão, Enfermagem, Cuidados de saúde mentalResumo
Introdução. Estudos na neurobiologia da depressão mostram uma desregulação de neurotransmissores em regiões cerebrais relacionadas à emoção, recompensa e funções executivas em indivíduos acometidos pela doença. A prática regular de exercício físico mostra-se como um importante aliado contra a depressão. Método. Buscou-se por meio de uma revisão sistemática, material bibliográfico de 2010 a 2021 que descrevesse o efeito neuroprotetor do exercício físico no tratamento da depressão. Utilizamos os descritores: Depressão, Neuroproteção e Exercício Físico nas bases de dados PubMed, LILACS, Science Direct, Web of Science e SCIELO. Resultados. Foram selecionados 04 artigos. O exercício físico regular promove alterações neurofisiológicas e neuroquímicas capazes de influenciar a doença, destacando-se o BDNF e o IGF-1 como fatores pró neurogênicos e alterações bioquímicas, somadas às alterações no eixo HPP durante o tratamento da depressão. Ressalta-se que o período de treinamento foi determinante para o efeito neuroprotetor. Tais evidências configuram o exercício físico como um excelente aliado no tratamento da depressão, principalmente a leve. Conclusão. Sugere-se pesquisas com duração de 09 semanas do protocolo de treinamento físico. Incentivamos mais pesquisas sobre os efeitos complexos induzidos pela inflamação do exercício. Além disso, podemos inferir que o estudo poderia ter resultados diferentes se o tempo para análise dessa neuroproteção fosse estendido ou se a monitoração de LPS fosse adicionada para controlar níveis de LPS x tempo de exercício x melhora do quadro depressivo.
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Copyright (c) 2023 Maria Jussara Medeiros Nunes, Paloma Katlheen Moura Melo, Marcília Ingrid Lima Barroso Nunes, Jean Carlos Souza Silva, Antônio William do Nascimento Fernandes, Anne Itamara Benigna Evangelista, Ivana Alice Teixeira Fonseca, Dayane Pessoa de Araújo
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Aceito: 2023-05-24
Publicado: 2023-06-29
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