Efeito neuroprotetor do exercício físico em modelos de depressão em roedores: uma meta-análise

Autores

DOI:

https://doi.org/10.34024/rnc.2023.v31.14734

Palavras-chave:

Neuroproteção, Exercício físico, Depressão, Enfermagem, Cuidados de saúde mental

Resumo

Introdução. Estudos na neurobiologia da depressão mostram uma desregulação de neurotransmissores em regiões cerebrais relacionadas à emoção, recompensa e funções executivas em indivíduos acometidos pela doença. A prática regular de exercício físico mostra-se como um importante aliado contra a depressão. Método. Buscou-se por meio de uma revisão sistemática, material bibliográfico de 2010 a 2021 que descrevesse o efeito neuroprotetor do exercício físico no tratamento da depressão. Utilizamos os descritores: Depressão, Neuroproteção e Exercício Físico nas bases de dados PubMed, LILACS, Science Direct, Web of Science e SCIELO. Resultados. Foram selecionados 04 artigos. O exercício físico regular promove alterações neurofisiológicas e neuroquímicas capazes de influenciar a doença, destacando-se o BDNF e o IGF-1 como fatores pró neurogênicos e alterações bioquímicas, somadas às alterações no eixo HPP durante o tratamento da depressão. Ressalta-se que o período de treinamento foi determinante para o efeito neuroprotetor. Tais evidências configuram o exercício físico como um excelente aliado no tratamento da depressão, principalmente a leve. Conclusão. Sugere-se pesquisas com duração de 09 semanas do protocolo de treinamento físico. Incentivamos mais pesquisas sobre os efeitos complexos induzidos pela inflamação do exercício. Além disso, podemos inferir que o estudo poderia ter resultados diferentes se o tempo para análise dessa neuroproteção fosse estendido ou se a monitoração de LPS fosse adicionada para controlar níveis de LPS x tempo de exercício x melhora do quadro depressivo.

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Biografia do Autor

Dayane Pessoa de Araújo, Universidade do Estado do Rio Grande do Norte

Graduated in Nursing from the University of Fortelaza- UNIFOR. Specialist in Clinical Care from the State University of Ceará - UECE. Master's and Doctorate in Pharmacology (Neuropharmacology) by the Department of Physiology and Pharmacology of the Federal University of Ceará-UFC. Currently, she is Adjunct Professor V of the Department of Nursing at the State University of Rio Grande do Norte and Local Coordinator of the Multicenter Graduate Program in Physiological Sciences at SBFis. She has research experience in Neurophysiology and Neuropharmacology, working mainly on the following topics: Neuroinflammation, Oxidative Stress, Natural Products, Antioxidants.

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Publicado

2023-06-29

Como Citar

Nunes, M. J. M., Melo, P. K. M. ., Nunes, M. I. L. B. ., Silva, J. C. S., Fernandes, A. W. do N., Evangelista, A. I. B., … Araújo, D. P. de. (2023). Efeito neuroprotetor do exercício físico em modelos de depressão em roedores: uma meta-análise. Revista Neurociências, 31, 1–28. https://doi.org/10.34024/rnc.2023.v31.14734

Edição

Seção

Revisão Sistemática
Recebido: 2023-01-10
Aceito: 2023-05-24
Publicado: 2023-06-29

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