Regulação negativa de Calbindina-D28k durante o envelhecimento neural animal
DOI:
https://doi.org/10.34024/rnc.2022.v30.13353Palavras-chave:
Calbindina-D28k, Neuroproteção, Proteínas ligantes de cálcio, envelhecimentoResumo
Introdução. A regulação nos níveis de cálcio (Ca2+) em neurônios é fundamental para a sinalização celular, transmissão sináptica e homeostase neuronal. A calbindina-D28k (CB) é uma proteína de ligação ao cálcio composta por seis domínios EF-hands, quatro das quais podem se ligar ao Ca2+ com alta afinidade molecular e regular os seus níveis intracelulares. O estudo é centrado em investigar o padrão de expressão de CB como um fator de neuroproteção durante o envelhecimento animal. Objetivo. Construir uma análise crítica de resultados de diferentes estudos originais com o objetivo de responder à pergunta: os níveis de Calbindina-D28k podem sofrer modificações durante a senescência animal? Além de uma discussão aprofundada sobre a temática atual. Método. A estratégia de busca dos dados utilizados contou com estudos obtidos por meio das bases de dados: Medical Literature Analysis and Retrieval System Online (MEDLINE/PubMed), Science Direct e Web of science. 57 artigos foram analisados. Resultados. As bases de dados apontaram para poucos estudos envolvendo a quantificação da proteína em neurônios humanos e estudos pós-morte, mas com base robusta em experimentos animais e in vitro. Os achados mostram que animais idosos têm expressão reduzida de CB. Os níveis CB relacionam-se com a neuroproteção em modelos animais. Conclusão. Diante dos achados, os dados sugerem que a regulação negativa de CB pode estar relacionada ao envelhecimento. As informações levantadas aqui podem ser utilizadas em estudos futuros sobre a patogênese de doenças que envolvam a neurodegeneração e expressão de proteínas ligantes de cálcio, mais especificamente a Calbindina-D28k.
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Copyright (c) 2022 Jean Carlos Souza Silva, Antônio William do Nascimento Fernandes, Maria Jussara Medeiros Nunes, Paulo Leonardo Araújo de Góis Morais, Ivana Alice Teixeira Fonseca, Rovena Clara Galvão Januário Engelberth, José Rodolfo Lopes de Paiva Cavalcanti, Dayane Pessoa de Araújo
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Aceito: 2022-08-04
Publicado: 2022-08-23
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