Alterações Neurológicas Na Covid-19: Uma Revisão Sistemática
DOI:
https://doi.org/10.34024/rnc.2020.v28.10949Palavras-chave:
COVID-19, SARS-CoV-2, Manifestações NeurológicasResumo
Introdução. A doença causada pelo novo SARS-CoV-2, Covid 19, possui capacidade de infectar diferentes células do corpo humano. Destarte para as células do SNC que podem ser infectadas juntamente com sistema respiratório. Estudos comprovam também a existência de sintomas neurológicos em pacientes com COVID-19. Objetivo. Revisar o material bibliográfico existente que descrevem os impactos neurológicos associados a COVID-19. Método. A estratégia de busca dos dados utilizados contou com estudos obtidos por meio de cinco bases de dados. Cada fonte de dados utilizou-se os filtros: título, assunto e tipo. O descritor Neurological foi combinado utilizando o operador booleano AND com os descritores: Coronavirus COVID-19 e Nervous System Diseases e seus correspondentes respectivos na língua portuguesa. Resultados. O Sars-cov-2 possui capacidade de neuroinvasão, assim como os outros tipos de corona vírus. A agressividade dos sintomas pode variar de sintomas mais leves até predispor a doenças cerebrovasculares agudas, em especial, nos pacientes com comorbidades (HAS eDM). Período de aparecimento dos sintomas pode ser em média 1-2 após aparecimento dos sintomas respiratórios. Em pacientes hipertensos os sintomas respiratórios podem ser amenizados, acarretando maior atenção para investigação e diagnóstico. Conclusão. Este estudo oferece novas e importantes informações clínicas sobre a COVID-19 e alterações neurológicas com alta contribuição aos profissionais da área da saúde em ampliarem o espectro de visão da doença além dos distúrbios cardiorrespiratórios, demonstrando a evolução clínica da doença para manifestações neurológicas associadas. Além de também auxiliá-los na identificação dos possíveis agravos em pacientes com COVID-19 e distúrbios neurológicos pré-existentes.
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Needham EJ, Chou SHY, Coles AJ, Menon DK. Neurological Implications of COVID-19 Infections. Neurocritical Care 2020;32:667-71. http://doi.org/10.1007/s12028-020-00978-4
Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms. ACS Chem Neurosci 2020;11:995-8. https://doi.org/10.1021/acschemneuro.0c00122
Das G, Mukherjee N, Ghosh S. Neurological Insights of COVID-19 Pandemic. ACS Chem Neurosci 2020;11:1206-9. https://doi.org/10.1021/acschemneuro.0c00201
Andersen KG, Rambaut A, Lipkin WI, Holmes EC, Garry RF. The proximal origin of SARS-CoV-2. Nat Med 2020;26:450-2. http://doi.org/10.1038/s41591-020-0820-9
Tay MZ, Poh CM, Rénia L, MacAry PA, Ng LFP. The trinity of COVID-19: immunity, inflammation and intervention. Nat Rev Immunol 2020;20:363-74. http://dx.doi.org/10.1038/s41577-020-0311-8
Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, et al. The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application. Ann Intern Med 2020;172:577-82. https://doi.org/10.7326/M20-0504
Felsenstein S, Herbert JA, McNamara PS, Hedrich CM. COVID-19: Immunology and treatment options. Clin Immunol 2020;215:108448. https://doi.org/10.1016/j.clim.2020.108448
Tian S, Xiong Y, Liu H, Niu L, Guo J, Liao M, et al. Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies. Mod Pathol 2020;33:1007-14. http://dx.doi.org/10.1038/s41379-020-0536-x
Danski MTR, Oliveira GLR, Pedrolo E, Lind J, Johann DA. Importância da prática baseada em evidências nos processos de trabalho do enfermeiro. Cienc Cuid Saude 2017;16:1-6. https://doi.org/10.4025/cienccuidsaude.v16i2.36304
Higgins J. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration, 2011. http://handbook.cochrane.org
Pallanti S. Importance of SARs-Cov-2 anosmia: from phenomenology to neurobiology. Comprehens Psych 2020;100:152184. https://doi.org/10.1016/j.comppsych.2020.152184
Tunç A, Ünlübaş Y, Alemdar M, Akyüz E. Coexistence of COVID-19 and acute ischemic stroke report of four cases. J Clin Neurosci 2020;77:227-9. https://doi.org/10.1016/j.jocn.2020.05.018
Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 2020;77:683-90. https://doi.org/10.1001/jamaneurol.2020.1127
Zayet S, Abdallah YB, Royer PY, Toko-Tchiundzie L, Gendrin V, Klopfenstein T. Encephalopathy in patients with COVID-19: 'Causality or coincidence?' J Med Virol 2020: 10.1002/jmv.26027. https://doi.org/10.1002/jmv.26027
Liguori C, Pierantozzi M, Spanetta M, Sarmati L, Cesta N, Iannetta M, et al. Subjective neurological symptoms frequently occur in patients with SARS-CoV2 infection. Brain Behav Immun 2020;88:11-6. https://doi.org/10.1016/j.bbi.2020.05.037
Heneka MT, Golenbock D, Latz E, Morgan D, Brown R. Immediate and long-term consequences of COVID-19 infections for the development of neurological disease. Alzheimers Res Ther 2020;12:69. https://doi.org/10.1186/s13195-020-00640-3
Toscano G, Palmerini F, Ravaglia S, Ruiz L, Invernizzi P, Cuzzoni MG, et al. Guillain–Barré Syndrome Associated with SARS-CoV-2. N Engl J Med 2020;382:2574-6. https://doi.org/10.1056/NEJMc2009191
Helms J, Kremer S, Merdji H, Clere-Jehl R, Schenck M, Kummerlen C, et al. Neurologic Features in Severe SARS-CoV-2 Infection. N Engl J Med 2020;382:2268-70. https://doi.org/10.1056/NEJMc2008597
Tsivgoulis G, Palaiodimou L, Katsanos AH, Caso V, Köhrmann M, Molina C, et al. Neurological manifestations and implications of COVID-19 pandemic. Ther Adv Neurol Disord 2020;13:175628642093203. https://doi.org/10.1177/1756286420932036
Tsai LK, Hsieh ST, Chao CC, Chen YC, Lin YH, Chang SC, et al. Neuromuscular disorders in severe acute respiratory syndrome. Arch Neurol 2004;61:1669-73.
https://doi.org/10.1001/archneur.61.11.1669
Wu Y, Xu X, Chen Z, Duan J, Hashimoto K, Yang L, et al. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun 2020;87:18-22. https://doi.org/10.1016/j.bbi.2020.03.031
Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. J Med Virol 2020;92:552-5. https://doi.org/10.1002/jmv.25728
Conklin J, Frosch MP, Mukerji S, Rapalino O, Maher M, Schaefer PW, et al. Cerebral Microvascular Injury in Severe COVID-19. medRxiv 2020. https://doi.org/10.1101/2020.07.21.20159376
Biadsee A, Biadsee A, Kassem F, Dagan O, Masarwa S, Ormianer Z. Manifestações olfativas e orais de COVID-19: sintomas relacionados ao sexo - uma via potencial para o diagnóstico precoce. Otolaryngol Head Neck Surg 2020;163:722-8.
https://doi.org/10.1177/0194599820934380
Kantonen J, Mahzabin S, Mäyränpää MI, Tynninen O, Paetau A, Andersson N, et al. Neuropathologic features of four autopsied COVID-19 patients. Brain Pathol 2020;0:1-5.
https://doi.org/10.1111/bpa.12889
Yu F, Du L, Ojcius DM, Pan C, Jiang S. Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China. Microbes Infect 2020;22:74-9. https://doi.org/10.1016/j.micinf.2020.01.003
Toljan K. Letter to the Editor Regarding the Viewpoint “Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanism”. ACS Chem Neurosci 2020;11:1192-4.
27.Poyiadji N, Shahin G, Noujaim D, Stone M, Patel S, Griffith B. COVID-19–associated Acute Hemorrhagic Necrotizing Encephalopathy: CT and MRI Features. Radiology 2020:201187. https://doi.org/10.1148/radiol.2020201187
20.Baig AM. Neurological manifestations in COVID-19 caused by SARS-CoV-2. CNS Neurosci Ther 2020;26:499-501. https://doi.org/10.1021/acschemneuro.0c00174
Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med 2020;8:420-2. https://doi.org/10.1016/S2213-2600(20)30076-X
Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 2020;395:565-74. http://dx.doi.org/10.1016/S0140-6736(20)30251-8
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Aceito: 2020-10-19
Publicado: 2020-12-02
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