Efeitos neuroprotetores do Pomegranate no acidente vascular encefálico:

Revisão Sistemática

Abstract

Introduction. Stroke is the major cause of disability in the population over 50 years. Given its epidemiological importance as a public health problem, due to the magnitude of its prevalence and incidence, preventive strategies should be adopted, such as the study of products to reduce the number of cases and severity. Pomegranate, Pomegranate fruit (Punica granatum L.), rich in phenolic compounds to which neuroprotective action is attributed, can become a functional food and a new therapeutic target. Equally rich in bioactive agents, such as Resveratrol, can also delay the complications of oxidative stress present in neuroinflammation, present in the pathogenesis of diseases such as Alzheimer's, Parkinson's and stroke. Method. This study conducted a systematic review to elect papers that are relevant to the neuroprotective relationship of Pomegranate and stroke. Results. The selected papers were considered as meeting the eligibility criteria for inclusion in the study. The result presented the final selection of 19 articles that met all criteria in the selection of studies and data extraction. From the complete reading of the selected articles, we can show that there is a relationship between Pomegranate consumption and decreased reactive oxygen species (ROS) and inflammation resulting from focal ischemia. Conclusion. This finding points out that polyphenol-enriched foods present in pomegranate, among other sources of bioavailability, may become a new therapeutic target in addition to decreasing the incidence of stroke-related risk predictors.