Inflamação do tipo corpo estranho reduz respostas regenerativas após lesão nervosa periférica

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DOI:

https://doi.org/10.34024/rnc.2019.v27.9656

Palavras-chave:

crescimento axonal, inflamação, macrófago, células de Schwann, degeneração walleriana, esponja

Resumo

A resposta ao corpo estranho resulta de um estímulo inflamatório persistente o qual é mediado por várias linhagens celulares.  A presença de células inflamatórias influencia diretamente o comportamento das células de Schwann (CS). Nesse sentido, nós estudamos a interação entre o processo inflamatório crônico e o processo degenerativo/regenerativo no nervo. Para tanto, usamos um modelo experimental de reação de corpo estranho induzida por implantes de esponja de poliéster-poliuretano ao redor do nervo ciático de camundongos após lesão por esmagamento. Interações in vitro entre as CS e exsudatos da esponja também foram estudadas.  Os resultados mostraram um grande infiltrado inflamatório com predominância de macrófagos. CS foram observadas dentro da esponja. Nos nervos envoltos por esponja foram observados reduzida expressão de NGFRp75, maior produção de colágeno, reduzido número de fibras degeneradas e da razão g, pior recuperação funcional. Além disso, os resultados in vitro demonstraram que macrófagos influenciaram a expressão de NGFRp75. Esses resultados indicam disfunção da limpeza da mielina e prejuízo na remielinização em nervos envoltos por esponja.

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Publicado

2019-12-27

Como Citar

dos Santos, A. C. M., Assis, A. D., Oliveira, T. G. do C., Deconte, S. R., Vieira, Érica dos S., Valverde, A. S. C., Fernandes, V. F., Araújo, F. de A., Simões, G. F., & Zanon, R. G. (2019). Inflamação do tipo corpo estranho reduz respostas regenerativas após lesão nervosa periférica. Revista Neurociências, 27, 1–28. https://doi.org/10.34024/rnc.2019.v27.9656

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Artigos Originais
Recebido: 2019-08-21
Aceito: 2019-10-15
Publicado: 2019-12-27