Relationship Between Parkinson's Disease And Epigenetic Modulation
DOI:
https://doi.org/10.34024/rnc.2019.v27.9615Keywords:
Parkinson's disease; epigenetics; neurodegenerative diseases; biomarkersAbstract
Introduction. Parkinson's disease (PD) is a neurodegenerative disorder prevalent in the elderly population. Despite scientific advances in the search for its etiology, the cellular and molecular mechanisms that trigger neurodegeneration are still not well understood. Although the clinical-functional outcomes have been improved, the available treatments do not prevent the progression of the disease. Therefore, there is a necessity for studies investigating mechanisms associated with the pathophysiology and progression of PD, as well as identifying biomarkers for early diagnosis and treatments that are more effective. In this context, epigenetics has been the subject of intense investigation due to its possible involvement in neurodegenerative diseases, as in PD. Objective. To review in the scientific literature the main epigenetic mechanisms involved in PD. Method. A literature review was carried out based on scientific articles indexed in Medline and Lilacs databases, from 2010 to 2018. Results. The articles reported alterations in epigenetic mechanisms in experimental models of PD as well as in patients. Conclusion. Thus, we hope that this field of study provides important molecular mechanisms that contribute to the understanding of the pathogenesis of PD, as well as the development of biomarkers of premature diagnosis and more effective therapeutic approaches for this pathology.
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Accepted 2019-12-20
Published 2019-12-26
