Relação entre Doença de Parkinson e Modulação Epigenética

Autores

  • Mariana Marchioro Centro Universitário Metodista IPA
  • Caroline Dani Centro Universitário Metodista IPA
  • Viviane Elsner Centro Universitário Metodista IPA
  • Cláudia Funchal Centro Universitário Metodista IPA

DOI:

https://doi.org/10.34024/rnc.2019.v27.9615

Palavras-chave:

Doença de Parkinson, epigenética, doenças neurodegenerativas, biomarcadores

Resumo

Introdução. A Doença de Parkinson (DP) é um distúrbio neurodegenerativo com prevalência na população longeva. Apesar dos avanços científicos na busca da sua etiologia, os mecanismos celulares e moleculares desencadeadores da neurodegeneração não são bem compreendidos. Ainda que se tenha aprimorado os desfechos clínico-funcionais, os tratamentos disponíveis não previnem a progressão da doença. Sendo assim, há necessidade de estudos que investiguem mecanismos associados com a fisiopatologia e progressão da DP, bem como identifiquem biomarcadores para diagnóstico precoce e tratamentos mais eficazes. Neste contexto, a epigenética tem sido alvo de intensa investigação devido ao seu possível envolvimento em doenças neurodegenerativas, como na DP. Objetivo. Revisar na literatura científica os principais mecanismos epigenéticos envolvidos na DP. Método. Foi realizada uma revisão de literatura baseada em artigos científicos indexados nas bases de dados Medline e Lilacs no período de 2010 a 2018. Resultados. Os artigos relataram alterações nos mecanismos epigenéticos em modelos experimentais da DP bem como em pacientes. Conclusão. Deste modo, esperamos que este campo de estudo forneça importantes mecanismos moleculares que contribuam para a compreensão da patogênese da DP, assim como no desenvolvimento de biomarcadores de diagnóstico prematuro e abordagens terapêuticas mais efetivas para esta patologia.

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Publicado

2019-12-26

Como Citar

Marchioro, M., Dani, C., Elsner, V., & Funchal, C. (2019). Relação entre Doença de Parkinson e Modulação Epigenética. Revista Neurociências, 27, 1–16. https://doi.org/10.34024/rnc.2019.v27.9615

Edição

v. 27 (2019)

Seção

Artigos de Revisão
Recebido: 2019-08-09
Aceito: 2019-12-20
Publicado: 2019-12-26

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