A Utilização da Toxina Botulinica A nas Distonias Musculares
DOI:
https://doi.org/10.34024/rnc.1993.v1.9071Keywords:
Botulinum toxin A, Dystonia, Focal dystoniasAbstract
The utilization of botulinum toxin A in Dystonia Botulinum toxin A is one of seven different serotypes of toxin produced by the Clostridium botulinum. Tetanic toxin (tetanospasmin) and botulinum toxin share very similar mechanism of action, but different neurospecificity. Botulinum toxin acts predominantly on cholinergic lower motor neuron terminals, blocking exocytosis, thus producing a chemical denervation. The result of this block is to produce a decrease in muscle contraction. This effect can be used as a treatment for many conditions where exaggerated muscle contraction cause involuntary movements or postures, as in focal dystonias, hemifacial spasm and other similar conditions. Essencial blepharospasm, spasmodic torticollis, spasmodic dysphonia, hemifacial spasm and many other conditions have been treated over the last eight years showing excellent results. The author presents some details concerning the utilization of the toxin and give some insights on the future of this new type of treatment.
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