Cefaléias e Neurotransmissão
DOI:
https://doi.org/10.34024/rnc.1994.v2.9044Palavras-chave:
Substancia P, Peptideo relacionado ao gene de calcitonina, Peptide° intestinal vasoativo, Neuropeptideo Y, Endotelina, Cefaléias, Sinalização celular, SumatdptanResumo
As cefaléias são comuns e freqüentes, mas sua fisiopatologia ainda é desconhecida. A neurotransmissão anormal deve ser o mecanismo envolvido na produção das dores primarias. Vasos cranianos são inervados por fibras simpáticas, parassimpaticas e sensitivas. Os principais neurotransmissores envolvidos são a substancia P. o peptideo relacionado ao gene da calcitonina, o peptide° intestinal vasoativo, o neuropeptideo Y, a endotelina, antra outros. Muitas drogas usadas contra cefaléias atuam na transmissão neurovascular. 0 conhecimento dos mecanismos responsáveis pela génese das cefaléias levara ao desenvolvimento de medicamentos mais eficazes.
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Publicado: 1994-10-31
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