Cefaléias e Neurotransmissão

Autores

  • Maurice B. Vincent Chafe do Setor de Cefaléias, Serviço de Neurologia, Hospital Universitário Clementine Fraga Filho, Universidade Federal do Rio de Janeiro
  • Sérgio A.P. Novis Professor Titular de Neurologia, Universidade Federal do Rio de Janeiro.

DOI:

https://doi.org/10.34024/rnc.1994.v2.9044

Palavras-chave:

Substancia P, Peptideo relacionado ao gene de calcitonina, Peptide° intestinal vasoativo, Neuropeptideo Y, Endotelina, Cefaléias, Sinalização celular, Sumatdptan

Resumo

As cefaléias são comuns e freqüentes, mas sua fisiopatologia ainda é desconhecida. A neurotransmissão anormal deve ser o mecanismo envolvido na produção das dores primarias. Vasos cranianos são inervados por fibras simpáticas, parassimpaticas e sensitivas. Os principais neurotransmissores envolvidos são a substancia P. o peptideo relacionado ao gene da calcitonina, o peptide° intestinal vasoativo, o neuropeptideo Y, a endotelina, antra outros. Muitas drogas usadas contra cefaléias atuam na transmissão neurovascular. 0 conhecimento dos mecanismos responsáveis pela génese das cefaléias levara ao desenvolvimento de medicamentos mais eficazes.

Métricas

Carregando Métricas ...

Downloads

Não há dados estatísticos.

Referências

SICUTERI, F., TESTI, A., ANSELMI, B. - Biochemical investigations in headache: increase in hydroxyindoleacefic acid excretion during migraine attacks. Int Arch Allergy 19,55-58, 1961.

HOKFELT, T., KELLERTH, J-0., NILSSON, G., PERNOW, B. - Experimental immunochemical studies on the localization and distribution of substance P in cat primary sensory neurons. Brain Res 100, 235-252, 1975.

BURNSTOCK, G. - Do some nerve cells release more than one transmitter? Neuroscience 1,239-248, 1976.

FURCHGOTT, R.F., ZAWADZKI, J.V. - The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288, 373-376, 1980.

OLESEN, J., LARSEN, B., LAURITZEN, M. - Focal Hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine. Ann Neurol 9, 344-352, 1981.

DUCKELS, S. P., SAID, S.I. - Vasoactive intestinal peptide as a neurotransmitter in the cerebral circulation. Eur J Pharmacol 78, 371-374,1982.

EDVINSSON, L., UDDMAN, R. - Immunohistochemical localization and dilatory effect of substance P on human cerebral vessels. Brain Res 232, 263-273, 1982.

EDVINSSON, L., DEQUEURCE, A., DUVERGER, D., MACKENZIE, E.T., SCATTON, B. - Central serotonergic nerves project to the pial vessels of the brain. Nature 306, 55-57, 1983.

ROSENFELD, MG., MERMOD, J.J., AMARA, S.G., SWANSON, LW., SAWCHENKO, P.E., RIVI ER, J., VALE, W. W., EVANS, R.M. - Production of a novel neuropeptide encoded by the calcitonin gene via tissue specific RNA processing. Nature 304, 129-135, 1983.

HARDEBO, J. E. - The involvement of trigeminal substance P neurons in cluster headache. An hypothesis. Headache 24,294-304, 1984.

BRAIN, S.D., WILLIAMS, T.J., TIPPINS, JR., MORRIS, H.R., MACINTYRE, I.. Calcitonin gene-related peptide is a potent vasodilator. Nature 313, 54-56, 1985.

UDDMAN, R., EDVINSSON, L., EKMAN, R., MCCULLOCH, J., KINGMAN, T.A. - Innervation of the feline cerebral vasculature bynerve fibres containing calcitonin gene-related peptide: trigeminal origin and co-existtance with substance P. Neurosci Lett 62, 131-136,1985.

NAHORSKI, S.R., JENKINSON, S., CHALLISS, R.A.J. - Lithium-induced disruption of cell signalling in brain: evidence implicating the phosphoinositide cycle. Acta Pharmacol Toxicol [suppl 1], 42-48, 1986.

UDDMAN, IR., EDVINSSON, L., EKBLAD, E., HAKANSON, R., SUNDLER, F. - Calcitonin gene-related peptide (CGRP): perivascular distribution and vasodilatory effects. Regui Pept 15, 1-24, 1986.

MARKOWITZ, S., SAITO, K., MOSKOWITZ, M.A. - Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura meter but not brain. J Neurosci 7, 4129-4136, 1987.

YANAGISAWA, M., KURIHARA, H., KIMURA, S., TOMOBE, Y., KOBAYASKY. M., MITSUI, Y., GOTO, K., MASAKI, T.- A novel potent vasoconstrictor peptide produced by vascular endothelia cells. Nature 332, 411-415,1988.

DARTT, D.A. - Signal tranduction and control of lacrimal protein secretion: a review. Curr Eye Res 8,619-636, 1989.

INOUE, A. YANAGISAWA, M., KIMURA, S., KASUYA, Y., MIYAUCHI, T., GOTO, K., MASAKI, T. - The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc Natl Acad Sci 86, 2863-2867,1989.

GOADSBY, P.J., EDVINSSON, L., EKMAN, R. - Vasoactive peptide release in the circulation of humans during migraine headaches. Ann Neurol 28, 183-187, 1990.

PEROUKTA, S.J. - Sumatriptan in acute migraine: pharmacology and review of world experience. Headache 30 [suppl 2], 554-560, 1990.

SICUTERI, F. FANCIULLACI, M., NICOLODI, M., GEPPETTI, P., FUSCO, B.M., MARABINI, S., ALLESTRANDRI, M., CAMPAGNOLO, V. - Substance P theory: a unique focus on the painful and painless phenomena of cluster headache. Headache 30, 69-79, 1990.

EDVINSSON, L. - Innervation and effects of dilatory neuropeptides on cerebral vessels. New aspects. Blood Vessels 28, 35-45, 1991.

FRIBERG, L., OLESEN, J., IVERSEN, H.K., SPERLING, B. - Migraine Pain associated with middle cerebral artery dilatation: reversal by sumatriptan. Lancet 338, 13-17, 1991.

HEMSEN, A. - Biochemical and functional characterization of endothelin peptides with special reference to vascular effects. Acta Physiol Stand 142[suppl 602], 1991.

IHARA, M., NOGUCHI, K., SAEKI, T., T8UCHIDA, S., FUKAMI, T., ISHIKAWA. K., NISHIKIBE, M., YANO, M. - Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor. Life Sci 50, 247-255, 1991.

OLESEN, J. - Cerebral and extracranial circulatory disturbances in migraine: pathophysiological implications. Cerebrovasc Brain Metab Rev 3, 1-28, 1991.

SH IN I, VB., VANHOUTTE, P.M. - Endothelin-1: a potent vasoactive peptide. Pharmacol Toxicol 69, 303-309, 1991.

THE SUMATRIPTAN CLUSTER HEADACHE STUDY GROUP., - Treatment of acute headache with sumatriptan. N Eng J Med 325, 322-326,1991.

BAKKEN, IB., VICENT, M.B., WHITE, L.R.,JUUL, R., EDVINSSON, L., SJAASTAD, O. - Mutual modification of vasoactivity by calcitonin gene-related peptide and endothelin-1 in isolated porcine ophthalmic artery. Neuropeptides 23, 209-214, 1992.

BAKKEN, I.J., VINCENT, M.B., WHITE, L.R., CAPPELEN, J., SKAANES, K. O., SJAASTAD, O. - Low concentrations of lithium and cyclooxygenase inhibitors enhance endothelin-1 (ET-1)-induced contractions in human temporal artery, but not in porcine ophthalmic artery. Headache 32, 475-479, 1992.

LANCE, J.W. - History of Involvement of 5-HT in primary headaches. in: OLESEN, J. & SAXENA, P.R. 5-hydroxytryptamine mechanisms in primary headaches. New York, Raven Press, 1992, pp. 19-28.

SAKURAI, T., YANAGISAWA, M., MASAKI, T. - Molecular characterization of endothelin receptors. Trends Pharmacol Sci 13, 103-108,1992.

VINCENT, M.B., WHITE, L.R., ELSAS, T., QVIGSTAD, G., SJAASTAD, O. -Substance P augments the rate of vasodilation induced by calcitonin gene-related peptide in porcine opthalmic artery in vitro. Neuropeptides 22, 137-141, 1992.

VINCENT, M.B. - Cyclooxygenase inhibitors modify the relaxant effect of vasoactive intestinal polypeptide and substance Pin isolated porcine ophthalmic artery. Cephalalgia 12, 15-19, 1992.

VINCENT, M.B. - Vasoactive peptides in the ocular/forehead area. Association with headache. Thesis. Trondheim, Tapir, 1992.

GOADSBY, P.J., EDVINSSON, L. - The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen un humans and cats. Ann Neurol 33, 48-56, 1993.

MOSKOWITZ, M.A., NOZAKI, K., KRAIG, R.P. - Neocortical spreading depression provokes the expression of c-for protein-like immunoreactivity within trigeminal nucleus caudalis via trigeminovascular mechanisms. J Neurosci 13, 1167-1177,1993.

VINCENT, M.B. WHITE, L.A., BAKKEN, kJ., SJAASTAD, O. - Sumatriptan relaxes isolated porcine ophthalmic artery, but inhibits VIP-induced relaxation. Cephalalgia 13, 378-382, 1993.

Downloads

Publicado

1994-10-31

Edição

Seção

Artigos Originais

Artigos Semelhantes

1 2 3 4 5 6 7 8 > >> 

Você também pode iniciar uma pesquisa avançada por similaridade para este artigo.