Menstrually related headache: mentrual migraine
DOI:
https://doi.org/10.34024/rnc.2000.v8.8936Keywords:
Menstrual migraine, pathophysiology, treatmentAbstract
The normal female life cycle is associated with a number of hormonal milestones: menarche, ovulation, pregnancy, breastfeeding, contraceptive use, menopause, and the use o replacement of sexual hormones. All these events and interventions promote modification of the levels and cycling of sexual hormones and may cause a change in the prevalence or intensity of headaches. Headaches occurring with premenstrual syndrome appear to be generated in the CNS neurons, including the serotoninergic painmodulating systems. Migraine-specific medications, such as the tryptans, may be effective for acute manegement of menstrual migraine. However, it is important to recognize the relationship between migraines and the menstrual cycle because these headaches may not be responsive to the usual antimigraine medications.
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References
Stewart WF, Lipton RB, Celentano DD, Reed ML. Prevalence of migraine headache in the United States. JAMA, 267:64-9, 1992.
Massiou H, Bousser MG. Influence of hormones on migrane. In: Olesen J, Tfelt-Hansen P, Welch KMA (eds.). The Headaches. Philadelphia, Lippincott Williams & Wilkins, 2000, p. 261-7.
Epstein MT, Hockaday JM, Hockaday TDR. Migraine and reproductive hormones throughout the menstrual cycle. Lancet, 1:543-8, 1975.
Macgregor A. Migraine in women. London, Martin Dunitz, 1999. p. 90.
Singh I, Singh D. Progesterone in the treatment of migraine. Lancet, 1:745, 1947.
Greene R, Dalton KD. The premenstrual syndrome. Brit Med J, 1:1007, 1953.
Dalton KD. Progesterone suppositories and pessaries in the treatment of menstrual migraine. Headache, 12: 150-8, 1973.
Somerville BW. The role of oestradiol withdrawal in the etiology of menstrual migraine. Neurology, 22:355-65, 1972.
Welch KMA, Darnely D, Simkings RT. The role of estrogen in migraine: a review and a hypothesis. Cephalalgia, 4:227-36, 1984.
DiCarlo C, Bifulco G, Pellicano M, Napolitano V, Nappi C. Hormonal treatment of premenstrual syndrome. Cephalalgia, 17(suppl. 20):17-9, 1997.
Fioroni L, Martignoni E, Facchinetti F. Changes of neuroendocrine axes in patients with menstrual migraine. Cephalalgia, 15:297-300, 1995.
Benedetto C, Allais G, Ciochetto D, DeLorenzo C. Pathopysiological aspects of menstrual migraine. Cephalalgia, 17(suppl. 20):2-4, 1997.
Carlson LA, Ekelund LG, Oro L. Clinical and metabolic effects of different doses of prostaglandin E in man. Acta Med Scand, 183:423-30, 1968.
Nattero G, Allais G, DeLorenzo C, Torre E, Ancona M, Benedetto C, Massobrio M. Menstrual migraine: new biochemical and psychological aspects. Headache, 28:103-7, 1988.
Nattero G, Allais G, DeLorenzo C, Benedetto C, Zonca M, Melzi E, Massobrio M. Relevance of prostaglandins in true menstrual migraine. Headache, 29:233-8, 1989.
Sances G, Martignoni E, Fioroni L, Blandini F, Facchinetti F, Nappi G. Naproxen sodium in menstrual migraine prophylaxis: a double-blind placebo controlled study. Headache, 30:705-9, 1990.
Benedetto C, Massobrio M, Zonca M. Menstrual migraine: a possible pathogenic implication of platelet function. Gynecol Endocrinol, 1:345-53, 1987.
Leira R, Martinez F, Castillo J, Rodriguez JR, Lema M, Noya M. Hormonal profile and changes in platelet aggregation in menstrual migraine. Neurologia, 5:306-9, 1990.
Taylor DL, Mathew RJ, Ho BT, Weinamn ML. Serotonin levels and platelet uptake during prementrual tension. Neuropsychobiology, 12:16-8, 1984.
Rapkin AJ, Edelmuth E, Chang LC, Reading AE, McGuire MT, Su TP. Whole blood serotonin in premenstrual syndrome. Obstet Gynecol, 70:533-7, 1987.
Silberstein SD, Merriam GR. Estrogens, progestins and headache. Neurology, 41:786-93, 1991.
D’Andrea G, Hasselmark L, Cananzi AR, Alecci M, Perini F, Zamberlan F, Welch KMA. Metabolism and menstrual cycle rhytmicity of serotonin in primary headaches. Headache, 35:216-21, 1995.
Allais G, Facco G, Ciochetto D, DeLorenzo C, Piore M, Benedetto C. Patterns of platelet aggregation in menstrual migraine. Cephalalgia, 17(suppl. 20):39-41, 1997.
Fioroni L, D’Andrea G, Alecci M, Cananzi A, Facchinetti F. Platelet serotonin pathway in menstrual migraine. Cephalalgia, 16:427-30, 1996.
Facchinetti F, Nappi G, Petraglia F, Volpe A, Genazzani AR. Oestradiol/progesterone inbalance and the premenstrual syndrome. Lancet 1983; ii:1302.
Ghose K, turner P. The menstrual cycle and tyramine pressor response test. Br J Clin Pharmacol, 4:500-2, 1977.
Magos AL, Brincat M, Zikha EJ, Studd JWW. Serum dopamineb-hydroxilase activity in mesntraul migraine. J Neurol Neurosurg Psychiatry, 48:328-31, 1985.
Jones SB, Bylund DB, Rieser CA, Shekim WO, Byer JA, Carr GW. α-2-adrenergic receptor binding in human platelets: alterations during the menstrual cycle. Clin Pharmacol Ther, 34:90-6, 1983.
Facchinetti F, Martignoni E, Nappi G, Fioroni L, Sances G, Genazzani AR. Premenstrual failure of α-adrenergic stimulation on hypothalamus-pituitary responses in menstrual migraine. Psychosom Med, 51:550-8, 1969.
Murialdo G, Fonzi S, Costelli P, Solinas GP, Parodi C, Marabini S. Urinary melatonin excretion though out the ovarian cycle in menstrual related migrane. Cephalalgia, 14:205-9, 1994.
Awaki E, Takeshima T, Takahashi K. A neuroendocrinological study in female migraneurs: prolactin and thyroid stimulting hormone responses. Cephalalgia, 9:187-93, 1989.
Consenso da Sociedade Brasileira de Cefaléia. Recomendações para o tratamento da crise migranosa. Arq Neuropsiquiatr, 58(2-A):371-89, 2000.
Pfaffenrath, V. Efficacy and safety of percutaneous estradiol vs placebo in menstrual migrane. Cephalalgia, 13 (suppl. 13):244, 1993.
Steiner M, Steinberg S, Stewart D et al. Fluoxetin in the treatment of premenstrual dysphoria. N Engl J Med, 332:1529-34, 1995.
Facchinetti F, Bonellie G, Kangasniemi P, Pascual J, Shuaib A. The efficacy and safety of subcutaneous sumatriptan in the acute treatment of menstrual migrane. Obstet Gynecol, 86:911-6, 1995.
Murray SC, Muse KN. Effective treatment of severe menstrual migraine headaches with gonadotropin-realising hormone agonist and “add-back” therapy. Fertil Steril, 67(2):390-3, 1997.
Newman LC, Lipton RB, Lay CL, Solomon S. A pilot study of oral sumatriptan as intermitent prophylaxis of menstruationrelated migrane. Neurology, 51:307-9, 1998.
Grunfeld E, Gresty MA. Relationship between motion sickness, migrane and menstruation in crew members of a “round the world” yacht race. Brain Research Bull, 47(5):433-6, 1998.
Silberstein SD, Armellino JJ, Hoffman HD, Battikha JP, Hamelsky SW, Stewart WF, Lipton RB. Treatment of menstruation-associated migraine with the nonprescription combination of acetaminophen, aspirin, and caffeine: results from three randomized, placebo-controlled studies. Clin Ther, 21(3):475-91, 1999.
