Estrogen replacement therapy effects in female patients with Alzheimer’s disease
DOI:
https://doi.org/10.34024/rnc.2003.v11.8890Keywords:
Estrogens, estradiol, Alzheimer, dementia, Estrogen Replacement Therapy (ERT), Hormone Replacement Therapy (HRT)Abstract
Review the effects of estrogen replacement therapy in Alzheimer’s disease (AD) women. Methods: A systematic review of randomized, doubleblind, placebo-controlled trials in Portuguese and English at Medline (1994-2001). We select studies that evaluated biological mechanism of estrogen's effects on the central nervous system. Results: these studies provide important insights into the clinical effects of estrogen replacement therapy on dementia symptoms, cognitive function, humor, behavior and regional cerebral flow. Conclusion: there weren't selfevident replay about the replacement therapy in patients with AD, however, there were suggested effects of estrogen in preventing onset of this disorder, so there are necessary more trials to prove this point.
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References
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