Tratamento Trombolítico no Acidente Vascular Cerebral Isquêmico
DOI:
https://doi.org/10.34024/rnc.2004.v12.8880Palavras-chave:
Acidente vascular cerebral, Trombólise, rt-PAResumo
O acidente vascular cerebral isquêmico (AVCi) é uma das mais importantes causas de mortalidade e morbidade em todo o mundo. A atual disponibilidade de métodos mecânicos e farmacológicos para o restabelecimento do fluxo sangüíneo cerebral em uma artéria obstruída tem possibilitado a mudança da historia natural do AVCi. Neste artigo discutimos as principais estratégias de recanalização arterial no AVCi agudo. A trombólise endovenosa com rt-PA é atualmente a terapêutica mais estudada e com maior evidência de benefício em promover recanalização arterial. Entretanto, uma importante limitação da trombólise endovenosa é a necessidade de seu uso dentro de uma janela temporal de 3 horas após o início dos sintomas, um dos motivos pelos quais outras estratégias foram desenvolvidas. Trombólise intra-arterial isolada ou combinada à endovenosa, métodos endovasculares como angioplastia e colocação de stent, e novas drogas trombolíticas são outros métodos discutidos. Alguns destes já fazem parte da rotina de muitos centros, enquanto outros ainda precisam ser testados em estudos mais robustos.
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Publicado: 2004-03-31
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