Importance of Dopamine Agonists in Early and Advanced Stages of Parkinsons Disease
DOI:
https://doi.org/10.34024/rnc.2006.v14.8753Keywords:
Parkinson Disease, Levodopa, Dyskinesias, Dopamine AgonistsAbstract
The main biochemical finding in Parkinson´s disease (PD) is dopamine deficiency as a result of cell loss in pars compacta of substantia nigra. Dopamine replacement with levo-dopa is efficacious. However, chronic exposure to this drug is associated with development of fluctuations and dyskinesias. It is thought that the short half-life of levodopa induces pulsatile stimulation of the dopamine receptors, leading to these complications. Dopamine agonist monotherapy in early PD decreases by half the development of fluctuations and prevents onset of dyskinesias. Add-on therapy with agonists once levo-dopa complications are present diminishes by 30% the off hours.
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References
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