O papel da Aquaporina-4 no Edema Cerebral
DOI:
https://doi.org/10.34024/rnc.2006.v14.8746Palavras-chave:
Canais de água, Aquaporinas, Aquaporina 4, Edema cerebralResumo
O edema cerebral, devido a suas repercussões sobre a morbidade e mortalidade de milhões de pacientes em todo o mundo, ainda constitui um desafio para a medicina. A última década trouxe novos conhecimentos sobre como a água transita pelas diversas interfaces de membrana no cérebro. Hoje sabemos que várias proteínas que formam canais estão envolvidas na redistribuição de volumes de água pelo tecido cerebral. Essas proteínas, chamadas aquaporinas, descobertas em 1992, estão elucidando diversos mecanismos da distribuição de água no cérebro e, possivelmente, serão alvos para novos fármacos com ação potencial sobre o edema cerebral. Nossa expectativa sobre essas possibilidades é reforçada pelo conhecimento de que, há muitos anos, já manipulamos proteínas similares usando fármacos hoje bem conhecidos.
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Publicado: 2006-12-31
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