The role of ion channels in Alzheimer disease

Authors

  • Maurus Marques de Almeida Holanda Neurocirurgião, Professor Substituto da Disciplina de Neurologia da UFPB Doutor em Farmacologia pela UFPB.
  • Luiz Márcio de Brito Marinho Segundo Acadêmico de Medicina da UFPB
  • Isac de Almeida Medeiros Farmacologista, Professor Doutor da UFPB
  • Bagnólia Araújo da Silva Farmacologista, Professora Doutora da UFPB

DOI:

https://doi.org/10.34024/rnc.2009.v17.8574

Keywords:

Ion Channels, Alzheimer Disease, Peptide, Therapy

Abstract

The hypothesis about the participation of ion channels in the pathogenesis of the Alzheimer disease (AD) suggests that the beta-amyloid peptide (Aβ), accumulated in plaques deposited in the brain, damages or even kills neurons by forming ion channels in cell membrane. Evidences found in several studies have been demonstrated this. The aim of the present revision is to analyze the role of ion channels in AD’s physiopathology.

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Published

2009-06-30

Issue

Vol. 17 No. 2 (2009)

Section

Revisão de Literatura

How to Cite

1.
Holanda MM de A, Segundo LM de BM, Medeiros I de A, Silva BA da. The role of ion channels in Alzheimer disease. Rev Neurocienc [Internet]. 2009 Jun. 30 [cited 2025 Dec. 19];17(2):141-5. Available from: https://periodicos.unifesp.br/index.php/neurociencias/article/view/8574