Terapia celular na Esclerose Lateral Amiotrófica
DOI:
https://doi.org/10.34024/rnc.2010.v18.8490Palavras-chave:
Esclerose Amiotrófica Lateral, Transplante de célulastronco, Terapia CelularResumo
Introdução. A Esclerose Lateral Amiotrófica é a doença de neurônio motor mais comum na idade adulta, com prognóstico sombrio e limitadas opções de tratamento o que leva a exploração de terapias alternativas. Método. Este trabalho, através de uma revisão da literatura, buscou descrever os avanços da utilização de células-tronco no tratamento da esclerose lateral amiotrófica. Resultados. Foram analisados 12 artigos em modelos animais e oito estudos clínicos em modelos humanos, sendo observada melhora clínica ou estagnação do quadro na maioria dos trabalhos. Nenhuma piora foi relacionada ao procedimento, porém algumas dúvidas não foram elucidadas como a melhor fonte de células a ser utilizada, a via de aplicação mais adequada, a população a ser mais beneficiada, bem como a necessidade ou não de se utilizar imunossupressão previamente a terapia celular. Conclusão. Desta forma, pode-se concluir que a terapia celular guarda grande potencial terapêutico, porém novos ensaios clínicos devem ser elaborados com a finalidade de elucidar estas dúvidas remanescentes.
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Publicado: 2010-06-30
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