Vitamin E and cognitive function
A literature review
DOI:
https://doi.org/10.34024/rnc.2010.v18.8488Keywords:
Vitamin E, Tocopherols, Antioxidants, Cognitive, Oxidative StressAbstract
Introduction. The oxidative stress seems to be one of the main factors contributing to the decline in cognitive function observed in neurological diseases standing out in the elderly as a sign of Alzheimer’s disease. According to the antioxidant properties, vitamin E plays the role of prevention of various diseases and has been reported in the prevention or reduction in the decline of cognition. Therefore, the objective of the work was through the scientific literature, whether supplementation of vitamin E, or even the status of this vitamin in the body, is able to prevent or reduce the cognitive damage in the elderly. Method. We performed a literature review by bibliographic searches, to search for articles from magazines and scientific journals that are indexed on the subject covering the period 1998 to 2008. Results. It was detected an inconsistency in the results with respect to the benefits of vitamin E, and 50% of the work pointed to an improvement in cognitive function while 50% did not observe any effect of this vitamin. Conclusion. Apparently, the light of current evidence, the use of vitamin supplementation for cognitive improvement appears questionable, perhaps, not recommended.
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References
Ortega RM, Raquejo AM, Lopez-Sobaler AM, Andres P, Navia B, Perea JM et al. Cognitive function in elderly people is influenced by vitamin E status. J Nutr 2002;132:2065-8.
Kang JH, Cook N, Manson J, Buring JE, Grodstein F. A randomized trial of vitamin E supplementation and cognitive function in women. Arch Intern Med 2006;166:2462-8.
Vianna LM. O estresse oxidativo nas doenças neurológicas. Cad Núcleo Est Pesq Esc Nutr (NEPEN) 2005;10:47-9.
Wolters M, Hickstein M, Flintermann A, Tewes U, Hahn A. Cognitive performance in relation to vitamin status in healthy elderly german women – the effect of 6 month multivitamin supplementation. Prev Med 2005;41:253-9.
Meydani M. Antioxidants and cognitive function. Nutr Rev 2001;59:75-80.
Costa VA, Aguila MB, Mandarim-de-Lacerda CA, Vianna, LM. Alphatocopherol supplementation favorable effects on blood pressure, blood viscosity and cardiac remodeling of spontaneously hypertension rats. J Nutr Biochem 2005;16:251-6.
Costa VA, Vianna LM. Effects of alpha-tocopherol supplementation on blood pressure and lipidic profile in streptozotocin-induced diabetes mellitus in spontaneously hypertension rats. Clin Chim Acta 2005; 351(1-2):101-4.
Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996;17:1-12.
Oxman AD, Guyatt GH. Validation of an index of the quality of review articles. J Clin Epidemiol 1991;44:1271-8.
Chan AS, Cheung MC, Law SC, Chan JH. Phase II of alpha-tocopherol in improving the cognitive of pacients with temporal lobe radionecrosis. Cancer 2004;100:398-404.
Petersen RC, Thomas RG, Grundman M, Bennett D, Doody R, Ferris S, et al. Vitamin E and donezepil for treatment of mild cognitive impairment. N Engl J Med 2005;325:2379-88.
Mcdonald SR, Sohal RS, Forster MJ. Concurrent administration of coenzyme Q10 and α-tocopherol improves learning in aged mice. Free Radic Biol Med 2005;38:729-36.
Delwing D, Bavaresco CS, Monteiro SC, Matte C, Netto CA, Wyse ATS. α-tocopherol and ascorbic acid prevent memory deficits provoked by chronic hyperprolinemia in rats. Behav Brain Res 2006;168:185-9.
Kolosova NG, Shchglova TV, Sergeeva SV, Loskutova LV. Long-term antioxidant supplementation attenuates oxidative stress markers and cognitive deficits in senescent-accelerated OXYS rats. Neurobiol Aging 2006;27: 1289-97.
Sumien N, Heirich KR, Sohal RS, Forster MJ. Short-term vitamin E intake fails to improve cognitive or psychomotor performance of aged mice. Free Radical Biol Med 2004;36:1424-33.
Shukitt-Hale B, Smith DE, Meydani M, Joseph JA. The effects of dietary antioxidants on psychomotor performance in aged mice. Exp Gerontol 1999;34:797-808.
Morris MC, Evans DA, Tangney CC, Bienias JL, Tangney CC, Wilson RS. Vitamin E and cognitive decline in older persons. Arch Neurol 2002;59:1125-32.
Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS, Aggarwal NT et al. Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change. Am J Clin Nutr 2005;81:508-14.
Grodstein F, Chen J, Willett WC. High-dose antioxidant supplements and cognitive function in community-dwelling elderly women. Am J Clin Nutr 2003;77:975-84.
Fotuhi M, Zandi PP, Hayden M, Khachaturian AS, Szekely CA, Wengreen H, et al. Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: The Cache County Study. Alzheimers Dement 2008;4:223-7.
Mendelsohn AB, Belle SH, Stoehr GP, Ganguli M. Use of antioxidant supplements and its association with cognitive function in the rural elderly cohort. Am J Epidemiol 1998;148:38-44.
Peacock JM, Folsom AR, Knopman DS, Mosley TH, Goff DC, Szklo M. Dietary antioxidant intake and cognitive performance in middle-aged aduls. Public Health Nutr 2000;3:337-43.
Kang JH, Grodstein F. Plasma carotenoids and tocopherols and cognitive function: A prospective study. Neurobiol Aging 2008;29:1394-403.
Engelhart MJ, Ruitenberg A, Meijer J, Kiliaan A, Van SWIETEN JC, Hofman A et al. Plasma levels of antioxidants are not associated with Alzheimer´s disease or cognitive decline: A population-based study. Dement Geriatr Cogn Disord 2005;19:134-9.
