Ketamina, da anestesia ao uso abusivo

artigo de revisão

Autores

  • Francisca Charliane Carlos da Silva Enfermeiro, Mestrando em Farmacologia – UFC, Fortaleza-CE, Brasil
  • Rodrigo Tavares Dantas Enfermeiro, Mestrando em Farmacologia – UFC, Fortaleza-CE, Brasil.
  • Maria d do Carmo de Oliveira Citó Enfermeira, Doutoranda em Farmacologia - UFC, Fortaleza-CE, Brasil
  • Silvânia Maria Mendes de Vasconcelos Enfermeira, Doutora em Farmacologia, Professora adjunta do Departamento de Fisiologia e Farmacologia da Faculdade de Medicina da Universidade Federal do Ceará, Atuação em Neuropsicofarmacologia – UFC, Fortaleza-CE, Brasil
  • Marta Maria de França Fonteles Farmacêutica, Pós-Doutorado pela University of Auckland, Nova Zelândia, Professora adjunta do Departamento de Farmácia da Universidade Federal do Ceará. Atuação em Neurofarmacologia – UFC, Fortaleza-CE, Brasil.
  • Glauce Socorro de Barros Viana Farmacêutica, Pós-Doutorado pela University of Maryland System, Professora adjunta do Departamento de Farmácia da Universidade Federal do Ceará, Atuação em Neuropsicofarmacologia – UFC, Fortaleza-CE, Brasil.
  • Francisca Cléa Florenço de Sousa Farmacêutica, Doutora em Farmacologia e Professora adjunta do Departamento de Fisiologia e Farmacologia da Faculdade de Medicina da Universidade Federal do Ceará – UFC, Fortaleza-CE, Brasil.

DOI:

https://doi.org/10.34024/rnc.2010.v18.8486

Palavras-chave:

Ketamina, Anestesia, Analgesia, Depressão, Drogas de Abuso.

Resumo

Objetivo. Realizar uma revisão bibliográfica sobre a ketamina, enfocando aspectos químicos e farmacocinéticos, seus mecanismos de ação, efeitos farmacológicos, usos terapêuticos, bem como aborda o uso da ketamina como droga de abuso. Ketamina. Método. Estudo de revisão bibliográfica através das bases de dados Pubmed, SciELO, Lilacs e Medline, na qual foram selecionados estudos clássicos e recentes relevantes para a discussão do tema abordado. Resultados. Após análise dos artigos selecionados, conclui-se que a ketamina apresenta perspectivas promissoras. Alguns estudos demonstraram propriedades analgésicas em relação à dor pós-operatória e outros revelaram uma ação antidepressiva rápida. Além disto, a ketamina também apresentou efeitos neuroprotetores em vários estudos animais. Embora a ketamina seja um campo promissor, essas ações precisam ser melhor investigadas. Atualmente, observou-se que o seu uso não se restringe apenas à prática clínica ou pesquisa, sendo frequentemente utilizada como droga de abuso pelos jovens em festas como um potente alucinógeno. Conclusão. Pesquisas sobre o uso recreacional da ketamina também são necessárias, especialmente no Brasil, assim como dados que mostrem a morbidade e mortalidade pelo uso desta substância como droga de abuso.

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2010-06-30

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