Synaptic Plasticity In Alzheimer’s Disease

Toward Early Detection Using Non-Invasive Protocols

Autores

  • Daniel A.C. Montoya Psychologist, Dosctor in Psychology, Assistant Professor, Fayetteville State University. Fayetteville, North Carolina, USA.

DOI:

https://doi.org/10.34024/rnc.2011.v19.8331

Palavras-chave:

Enfermedad de Alzheimer, Potenciación de Larga Duración, Fallo Sináptico, Plasticidad Sináptica, Potenciales Evocados

Resumo

It has been proposed that Alzheimer’s disease is a synaptic failure associated with subtle memory loss during the early stages of the disorder. If this is the case, it should prove useful to elucidate the mechanisms of synaptic plasticity during early stages of the condition. On the other hand, Long Term Potentiation, one of the best-known mechanisms of synaptic plasticity has been recently confirmed absent in Alzheimer’s disease patients. This link may lead to focus efforts in early detection of synaptic failure and development of preventive approaches aiming to improve synaptic plasticity. Here we review some new evidence in the study of cortical plasticity in humans that could be applied to the early detection of the disorder.

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Publicado

2011-12-31

Como Citar

Montoya, D. A. (2011). Synaptic Plasticity In Alzheimer’s Disease: Toward Early Detection Using Non-Invasive Protocols. Revista Neurociências, 19(4), 711–717. https://doi.org/10.34024/rnc.2011.v19.8331

Edição

Seção

Revisão de Literatura
Recebido: 2019-02-25
Publicado: 2011-12-31