Synaptic Plasticity In Alzheimer’s Disease
Toward Early Detection Using Non-Invasive Protocols
DOI:
https://doi.org/10.34024/rnc.2011.v19.8331Palavras-chave:
Enfermedad de Alzheimer, Potenciación de Larga Duración, Fallo Sináptico, Plasticidad Sináptica, Potenciales EvocadosResumo
It has been proposed that Alzheimer’s disease is a synaptic failure associated with subtle memory loss during the early stages of the disorder. If this is the case, it should prove useful to elucidate the mechanisms of synaptic plasticity during early stages of the condition. On the other hand, Long Term Potentiation, one of the best-known mechanisms of synaptic plasticity has been recently confirmed absent in Alzheimer’s disease patients. This link may lead to focus efforts in early detection of synaptic failure and development of preventive approaches aiming to improve synaptic plasticity. Here we review some new evidence in the study of cortical plasticity in humans that could be applied to the early detection of the disorder.
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Publicado: 2011-12-31