Revisão Sistemática sobre Tratamento Medicamentoso para Dor no Membro Fantasma

Autores

  • Sara Socorro Faria Fisioterapeuta, aluna do Programa de Mastologia, Universidade Federal de Goiás, Goiânia-GO, Brasil.
  • Pedro Leme Silva Pedro Leme Silva Pedro Leme Silva Fisioterapeuta, Professor Adjunto de Fisiologia, Laboratório de Investigação Pulmonar, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro-RJ, Brasil.

DOI:

https://doi.org/10.34024/rnc.2014.v22.8091

Palavras-chave:

Amputação, Fármacos, Revisão Sistemática

Resumo

Objetivo. Realizar revisão sistemática da literatura sobre as possíveis condutas farmacológicas utilizadas para tratamento da dor do mem­bro fantasma. Método. A estratégia de busca foi realizada nas bases de dados eletrônicas Cochrane, Pubmed e Lilacs através da consulta de descritores específicos. A busca consistiu de artigos apresentados na íntegra, escritos em inglês ou espanhol, adultos humanos de ambos os sexos, publicados no período de 1990 a 2012. Resultados. Após a aplicação dos critérios de exclusão, foram selecionados 20 artigos. Através da análise, verificou-se que existem possibilidades terapêuticas positivas a curto prazo a serem utilizadas, dentre elas destacam-se os opióides, gabapentina e a quetamina. A morfina (oral e intravenosa) foi eficaz na diminuição da intensidade da dor a curto-prazo. Com ex­ceção da memantina, os antagonistas do receptor NMDA, morfina e a quetamina apresentaram efeitos analgésicos. Entretanto, os resultados obtidos com a gabapentina em termos de alívio da dor não foram sig­nificativos. O direcionamento da eficácia da calcitonina e dextrome­torfano necessitam maiores esclarecimentos. Conclusão. A morfina e a quetamina demonstraram ser eficazes como analgésicos de curta duração. Maiores estudos tornam-se necessários para esclarecer os re­ais benefícios da amitriptilina, o cloridrato de tramadol, memantina e a toxina botulínica. Intervenções em pesquisas com maior número de participantes são importantes, a fim de estabelecer recomendações na prática terapêutica.

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Publicado

2014-06-30

Como Citar

Faria, S. S., & Pedro Leme Silva, P. L. S. P. L. S. (2014). Revisão Sistemática sobre Tratamento Medicamentoso para Dor no Membro Fantasma. Revista Neurociências, 22(2), 177–188. https://doi.org/10.34024/rnc.2014.v22.8091

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