Estudo comparativo entre música clássica e outras músicas sobre a extinção do medo em rato
DOI:
https://doi.org/10.34024/rnc.2025.v33.20347Palavras-chave:
Memória de longo prazo, Memória aversiva, Extinção da memória, Musicoterapia, Efeito MozartResumo
Introdução. A exposição à música é benéfica para a aquisição e consolidação da memória. No entanto, pouco se sabe sobre o efeito da música na extinção da memória. Método. Analisamos a influência da exposição à Sonata K448 de Mozart e a outros estilos musicais na extinção da memória do medo em ratos. Ratos Wistar machos foram expostos a diferentes estilos musicais ou sons ambientais desde o período gestacional até a vida adulta. No 39º dia do experimento, os animais foram submetidos ao treinamento de condicionamento aversivo por meio de estimulação elétrica para induzir a memória do medo. Do 67º ao 71º dia, os ratos passaram por testes de extinção do medo, nos quais retornaram à caixa de condicionamento aversivo, mas sem a aplicação de estímulos elétricos. No 92º dia, os animais foram novamente colocados na caixa para o teste de recordação, também sem estímulos elétricos. Resultados. A partir do terceiro dia de extinção, os grupos condicionados expostos a Mozart e a músicas clássicas apresentaram menor comportamento de freezing quando comparados aos grupos expostos à música eletrônica e ao som ambiente. No teste de evocação, o grupo condicionado exposto a Mozart não apresentou diferença significativa em relação ao grupo não condicionado, enquanto os demais grupos condicionados mantiveram níveis elevados de freezing. Conclusão. Nosso estudo sugere que a exposição a músicas clássicas favorece o processo de extinção da memória do medo. Embora limitado a testes comportamentais, os resultados indicam possíveis implicações positivas para o tratamento de transtornos de ansiedade.
Métricas
Referências
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Copyright (c) 2025 Paulo Henrique Martinelli Oliveira, Rodolfo Souza de Faria, Luciano Magalhães Vitorino, Clarissa Maria Ferreira Trzesniak, Jackelline Camargo Preto, Lelis do Vale Miranda, Amanda Di Gesu, Diego Henrique Pietrobon, Iara Leite de Faria, Cesar Renato Sartori
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
