Consumo de frutas e risco de constipação em pessoas com Doença de Parkinson

Autores

DOI:

https://doi.org/10.34024/rnc.2025.v33.20260

Palavras-chave:

Doença de Parkinson, Consumo alimentar, Constipação Intestinal

Resumo

Introdução. A Doença de Parkinson (DP) é um distúrbio neurodegenerativo caracterizado por sintomas motores e não motores. Entre os sintomas não motores, a constipação intestinal é uma das manifestações gastrointestinais mais frequentemente observadas. Objetivo. Avaliar o consumo alimentar e a frequência de evacuação intestinal em indivíduos com DP. Método. Um inquérito clínico online foi realizado em maio de 2024, por meio da plataforma Fox Insight Data Exploration Network. Um total de 416 indivíduos com DP participou, respondendo a um questionário online. Resultados. A média de idade dos participantes foi de 64,7±5,22 anos (variação: 49,3–73,9), e a média de idade ao diagnóstico foi de 59,0±5,25 anos (variação: 41,9–68,3). A maioria dos participantes (88%) havia recebido o diagnóstico nos últimos 5 anos. A constipação foi relatada por 37,5% dos participantes. Observou-se uma associação significante entre o consumo de frutas e a constipação (p=0,0001). Maior consumo diário de frutas foi associado à presença de constipação, enquanto o consumo semanal foi mais comum entre aqueles sem constipação. Outras variáveis, como consumo de vegetais, tempo de diagnóstico e sexo, não apresentaram associação significante com a constipação.  Conclusão. Estudos futuros devem investigar a adesão a padrões alimentares saudáveis, ricos em frutas e vegetais, com ênfase especial naqueles com propriedades laxativas, a fim de melhorar os sintomas gastrointestinais em indivíduos com DP.

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Referências

1.Willis AW, Roberts E, Beck JC, Fiske B, Ross W, Savica R, et al. Parkinson’s Foundation P4 Group. Incidence of Parkinson disease in North America. NPJ Parkinsons Dis 2022;8:170. https://doi.org/10.1038/s41531-022-00410-y

2.Dickson DW. Neuropathology of Parkinson disease. Parkinsonism Relat Disord 2018;46(Suppl 1):S30-3. https://doi.org/10.1016/j.parkreldis.2017.07.033

3.De Rui M, Inelmen EM, Trevisan C, Pigozzo S, Manzato E, Sergi G. Parkinson's disease and the non-motor symptoms: hyposmia, weight loss, osteosarcopenia. Aging Clin Exp Res 2020;32:1211-8. https://doi.org/10.1007/s40520-020-01470-x

4.Ma K, Xiong N, Shen Y, Han C, Liu L, Zhang G, et al. Weight Loss and Malnutrition in Patients with Parkinson's Disease: Current Knowledge and Future Prospects. Front Aging Neurosci 2018;10:1. https://doi.org/10.3389/fnagi.2018.00001

5.Fracasso BM, Moraes MB, Gomez R, Hilbig A, Rabito EI. Protein intake and the use of levodopa in patients with Parkinson’s disease. Rev ChilNutr 2013;40:102-6. https://doi.org/10.4067/S0717-75182013000200001

6.Bazán-Rodríguez L, Cruz-Vicioso R, Cervantes-Arriaga A, Alcocer-Salas A, Pinto-Solís D, Rodríguez-Violante M. Malnutrition and Associates Motor and Non-motor factors in People with Parkinson's disease. Rev Invest Clin 2020;72:293–9. https://doi.org/10.24875/RIC.20000010

7.Paul BS, Singh T, Paul G, Jain D, Singh G, Kaushal S, et al. Prevalence of Malnutrition in Parkinson's Disease and Correlation with Gastrointestinal Symptoms. Ann Indian Acad Neurol 2019;22:447-52. https://doi.org/10.4103/aian.AIAN_349_18

8.Mischley LK, Lau RC, Bennett RD. Role of Diet and Nutritional Supplements in Parkinson's Disease Progression. Oxid Med Cell Longev 2017;2017:6405278. https://doi.org/10.1155/2017/6405278

9.Bisaglia M. Mediterranean Diet and Parkinson's Disease. Int J Mol Sci 2022;24:42. https://doi.org/10.3390/ijms24010042

10.Ying AF, Khan S, Wu Y, Jin A, Wong ASY, Tan EK, et al. Dietary Antioxidants and Risk of Parkinson's Disease in the Singapore Chinese Health Study. Mov Disord 2020;35:1765-73. https://doi.org/10.1002/mds.28173

11.Hughes KC, Gao X, Kim IY, Rimm EB, Wang M, Weisskopf MG, et al. Intake of antioxidant vitamins and risk of Parkinson's disease. Mov Disord 2016;31:1909-14. https://doi.org/10.1002/mds.26819

12.Rusch C, Beke M, Tucciarone L, Nieves C, Jr Ukhanova M, Tagliamonte MS, et al. Mediterranean Diet Adherence in People With Parkinson’s Disease Reduces Constipation Symptoms and Changes Fecal Microbiota After a 5-Week Single Arm Pilot Study. Sec Frontiers Neurology 2021;12:794640. https://doi.org/10.3389/fneur.2021.756538

13.Knight E, Geetha T, Burnett D, Babu JR. The Role of Diet and Dietary Patterns in Parkinson’s Disease. Nutrients 2022;14:4472. https://doi.org/10.3390/nu14214472

14.Thompson WG, Longstreth GF, Drossmand DA, Heaton KW, Irvine EJ, Müller-Lissner SA. Functional bowel disorders and functional abdominal pain. Gut 1999;45(Suppl 2):1143-7. https://doi.org/10.1136/gut.45.2008.ii43

15.Cerri S, Mus L, Blandini F. Parkinson's Disease in Women and Men: What's the Difference? J Parkinsons Dis 2019;3:501-15. https://doi.org/10.3233/JPD-191683

16.Khadrawy YA, Salem AM, El-Shamy KA, Ahmed EK, Fadl NN, Hosny EN. Neuroprotective and Therapeutic Effect of Caffeine on the Rat Model of Parkinson's Disease Induced by Rotenone. J Diet Suppl 2017;14:553-72. https://doi.org/10.1080/19390211.2016.1275916

17.Nehlig A. Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption. Pharmacol Rer 2018;70:384-411. https://doi.org/10.1124/pr.117.014407

18.Schwiertz A, Spiegel J, Dillmann U, Grundma NN, Bürmann, J, Faßbender K, et al. Fecal markers of intestinal inflammation and intestinal permeability are elevated in Parkinson's disease. Parkinsonism Relat Disord 2018;50:104-7. https://doi.org/10.1016/j.parkreldis.2018.02.022

19.Bellini M, Gambaccini D, Usai-Satta P, Bortoli N, Bertani L, Marchi C. Irritable bowel syndrome and chronic constipation: Fact and fiction. World J Gastroenterol 2015;21:11362-70. https://doi.org/10.3748/wjg.v21.i40.11362

20.Bellini M, Tonarelli S, Barracca F, Rettura F, Pancetti A, Ceccarelli L, et al. Chronic Constipation: Is a Nutritional Approach Reasonable? Nutrients 2021;13:3386. https://doi.org/10.3390/nu13103386

21.Bernaud FR, Rodrigues TC. Dietary fiber – Adequate intake and effects on metabolism health. Arq Bras Endocrinol Metab 2013;57:397-405. https://doi.org/10.1590/S0004-27302013000600001

22.Metcalfe-Roach A, Yu AC, Golz E, Cirstea M, Sundvick k, Kliger D, et al. MIND and Mediterranean Diets Associated with Later Onset of Parkinson's Disease. Mov Disord 2021;36:977-84. https://doi.org/10.1002/mds.28464

23.Leta V, Klingelhoefer L, Longardner K, Campagnolo M, Levent HC, Aureli F, et al. International Parkinson and Movement Disorders Society Non-Motor Parkinson's Disease Study Group. Gastrointestinal barriers to levodopa transport and absorption in Parkinson's disease. Eur J Neurol 2023;30:1465-80. https://doi.org/10.1111/ene.15734

24.Perfeito R, Rego AC. Papel da Alfa-sinucleína e da Disfunção Mitocondrial associada à Doença de Parkinson. Rev Neurocienc 2012;20:273-84. https://doi.org/10.34024/rnc.2012.v20.8280

25.Tosefsky KN, Zhu J, Wang YN, Lam JST, Cammalleri A, Appel-Cresswell S. The Role of Diet in Parkinson's Disease. J Parkinsons Dis 2024;14:S21-34. https://doi.org/10.3233/JPD-230264

26.Peters S, Gallo V, Vineis P, Middleton LT, Forsgren L, Sacerdote MD, et al. Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort. Desordem Mov 2020;35:1258-63. https://doi.org/10.1002/mds.28039

27.Molsberry S, Bjornevik K, Hughes KC, Healy B, Schwarzschild M, Ascherio A. Diet pattern and prodromal features of Parkinson disease. Neurology 2020;95:e2095-108. https://doi.org/10.1212/WNL.0000000000010523

28.Molsberry S, Bjornevik K, Hughes KC, Healy B, Schwarzschild M, Ascherio A. Diet pattern and prodromal features of Parkinson disease. Neurology 2020;95:e2095-108. https://doi.org/10.1212/WNL.0000000000010523

29.Liu YH, Jensen GL, Na M, Mitchell DC, Wood CGD, Still C, et al. Diet Quality and Risk of Parkinson's Disease: A Prospective Study and Meta-Analysis. J Parkinsons Dis 2021;11:337-47. https://doi.org/10.3233/JPD-202290

30.Seidl SE, Santiago JA, Bilyk H, Potashkin JA. The emerging role of nutrition in Parkinson’s disease. Front Aging Neurosci Nutr Parkinsons Dis 2014;6:36. https://doi.org/10.3389/fnagi.2014.00036

31.Kent G, Kehoe L, Flynn A, Walton J. Plant-based diets: a review of the definitions and nutritional role in the adult diet. Proc Nutr Soc 2022;81:62-74. https://doi.org/10.1017/S0029665121003839

32.McCarty MF. Does a vegan diet reduce risk for Parkinson's disease? Med Hypotheses 2001;57:318-23. https://doi.org/10.1054/mehy.2000.1321

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2025-10-09

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1.
Dias Fernandez R, Lopes do Santos Lobato B. Consumo de frutas e risco de constipação em pessoas com Doença de Parkinson. Rev Neurocienc [Internet]. 9º de outubro de 2025 [citado 17º de dezembro de 2025];33:1-22. Disponível em: https://periodicos.unifesp.br/index.php/neurociencias/article/view/20260