Consumo de frutas e risco de constipação em pessoas com Doença de Parkinson
DOI:
https://doi.org/10.34024/rnc.2025.v33.20260Palavras-chave:
Doença de Parkinson, Consumo alimentar, Constipação IntestinalResumo
Introdução. A Doença de Parkinson (DP) é um distúrbio neurodegenerativo caracterizado por sintomas motores e não motores. Entre os sintomas não motores, a constipação intestinal é uma das manifestações gastrointestinais mais frequentemente observadas. Objetivo. Avaliar o consumo alimentar e a frequência de evacuação intestinal em indivíduos com DP. Método. Um inquérito clínico online foi realizado em maio de 2024, por meio da plataforma Fox Insight Data Exploration Network. Um total de 416 indivíduos com DP participou, respondendo a um questionário online. Resultados. A média de idade dos participantes foi de 64,7±5,22 anos (variação: 49,3–73,9), e a média de idade ao diagnóstico foi de 59,0±5,25 anos (variação: 41,9–68,3). A maioria dos participantes (88%) havia recebido o diagnóstico nos últimos 5 anos. A constipação foi relatada por 37,5% dos participantes. Observou-se uma associação significante entre o consumo de frutas e a constipação (p=0,0001). Maior consumo diário de frutas foi associado à presença de constipação, enquanto o consumo semanal foi mais comum entre aqueles sem constipação. Outras variáveis, como consumo de vegetais, tempo de diagnóstico e sexo, não apresentaram associação significante com a constipação. Conclusão. Estudos futuros devem investigar a adesão a padrões alimentares saudáveis, ricos em frutas e vegetais, com ênfase especial naqueles com propriedades laxativas, a fim de melhorar os sintomas gastrointestinais em indivíduos com DP.
Métricas
Referências
1.Willis AW, Roberts E, Beck JC, Fiske B, Ross W, Savica R, et al. Parkinson’s Foundation P4 Group. Incidence of Parkinson disease in North America. NPJ Parkinsons Dis 2022;8:170. https://doi.org/10.1038/s41531-022-00410-y
2.Dickson DW. Neuropathology of Parkinson disease. Parkinsonism Relat Disord 2018;46(Suppl 1):S30-3. https://doi.org/10.1016/j.parkreldis.2017.07.033
3.De Rui M, Inelmen EM, Trevisan C, Pigozzo S, Manzato E, Sergi G. Parkinson's disease and the non-motor symptoms: hyposmia, weight loss, osteosarcopenia. Aging Clin Exp Res 2020;32:1211-8. https://doi.org/10.1007/s40520-020-01470-x
4.Ma K, Xiong N, Shen Y, Han C, Liu L, Zhang G, et al. Weight Loss and Malnutrition in Patients with Parkinson's Disease: Current Knowledge and Future Prospects. Front Aging Neurosci 2018;10:1. https://doi.org/10.3389/fnagi.2018.00001
5.Fracasso BM, Moraes MB, Gomez R, Hilbig A, Rabito EI. Protein intake and the use of levodopa in patients with Parkinson’s disease. Rev ChilNutr 2013;40:102-6. https://doi.org/10.4067/S0717-75182013000200001
6.Bazán-Rodríguez L, Cruz-Vicioso R, Cervantes-Arriaga A, Alcocer-Salas A, Pinto-Solís D, Rodríguez-Violante M. Malnutrition and Associates Motor and Non-motor factors in People with Parkinson's disease. Rev Invest Clin 2020;72:293–9. https://doi.org/10.24875/RIC.20000010
7.Paul BS, Singh T, Paul G, Jain D, Singh G, Kaushal S, et al. Prevalence of Malnutrition in Parkinson's Disease and Correlation with Gastrointestinal Symptoms. Ann Indian Acad Neurol 2019;22:447-52. https://doi.org/10.4103/aian.AIAN_349_18
8.Mischley LK, Lau RC, Bennett RD. Role of Diet and Nutritional Supplements in Parkinson's Disease Progression. Oxid Med Cell Longev 2017;2017:6405278. https://doi.org/10.1155/2017/6405278
9.Bisaglia M. Mediterranean Diet and Parkinson's Disease. Int J Mol Sci 2022;24:42. https://doi.org/10.3390/ijms24010042
10.Ying AF, Khan S, Wu Y, Jin A, Wong ASY, Tan EK, et al. Dietary Antioxidants and Risk of Parkinson's Disease in the Singapore Chinese Health Study. Mov Disord 2020;35:1765-73. https://doi.org/10.1002/mds.28173
11.Hughes KC, Gao X, Kim IY, Rimm EB, Wang M, Weisskopf MG, et al. Intake of antioxidant vitamins and risk of Parkinson's disease. Mov Disord 2016;31:1909-14. https://doi.org/10.1002/mds.26819
12.Rusch C, Beke M, Tucciarone L, Nieves C, Jr Ukhanova M, Tagliamonte MS, et al. Mediterranean Diet Adherence in People With Parkinson’s Disease Reduces Constipation Symptoms and Changes Fecal Microbiota After a 5-Week Single Arm Pilot Study. Sec Frontiers Neurology 2021;12:794640. https://doi.org/10.3389/fneur.2021.756538
13.Knight E, Geetha T, Burnett D, Babu JR. The Role of Diet and Dietary Patterns in Parkinson’s Disease. Nutrients 2022;14:4472. https://doi.org/10.3390/nu14214472
14.Thompson WG, Longstreth GF, Drossmand DA, Heaton KW, Irvine EJ, Müller-Lissner SA. Functional bowel disorders and functional abdominal pain. Gut 1999;45(Suppl 2):1143-7. https://doi.org/10.1136/gut.45.2008.ii43
15.Cerri S, Mus L, Blandini F. Parkinson's Disease in Women and Men: What's the Difference? J Parkinsons Dis 2019;3:501-15. https://doi.org/10.3233/JPD-191683
16.Khadrawy YA, Salem AM, El-Shamy KA, Ahmed EK, Fadl NN, Hosny EN. Neuroprotective and Therapeutic Effect of Caffeine on the Rat Model of Parkinson's Disease Induced by Rotenone. J Diet Suppl 2017;14:553-72. https://doi.org/10.1080/19390211.2016.1275916
17.Nehlig A. Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption. Pharmacol Rer 2018;70:384-411. https://doi.org/10.1124/pr.117.014407
18.Schwiertz A, Spiegel J, Dillmann U, Grundma NN, Bürmann, J, Faßbender K, et al. Fecal markers of intestinal inflammation and intestinal permeability are elevated in Parkinson's disease. Parkinsonism Relat Disord 2018;50:104-7. https://doi.org/10.1016/j.parkreldis.2018.02.022
19.Bellini M, Gambaccini D, Usai-Satta P, Bortoli N, Bertani L, Marchi C. Irritable bowel syndrome and chronic constipation: Fact and fiction. World J Gastroenterol 2015;21:11362-70. https://doi.org/10.3748/wjg.v21.i40.11362
20.Bellini M, Tonarelli S, Barracca F, Rettura F, Pancetti A, Ceccarelli L, et al. Chronic Constipation: Is a Nutritional Approach Reasonable? Nutrients 2021;13:3386. https://doi.org/10.3390/nu13103386
21.Bernaud FR, Rodrigues TC. Dietary fiber – Adequate intake and effects on metabolism health. Arq Bras Endocrinol Metab 2013;57:397-405. https://doi.org/10.1590/S0004-27302013000600001
22.Metcalfe-Roach A, Yu AC, Golz E, Cirstea M, Sundvick k, Kliger D, et al. MIND and Mediterranean Diets Associated with Later Onset of Parkinson's Disease. Mov Disord 2021;36:977-84. https://doi.org/10.1002/mds.28464
23.Leta V, Klingelhoefer L, Longardner K, Campagnolo M, Levent HC, Aureli F, et al. International Parkinson and Movement Disorders Society Non-Motor Parkinson's Disease Study Group. Gastrointestinal barriers to levodopa transport and absorption in Parkinson's disease. Eur J Neurol 2023;30:1465-80. https://doi.org/10.1111/ene.15734
24.Perfeito R, Rego AC. Papel da Alfa-sinucleína e da Disfunção Mitocondrial associada à Doença de Parkinson. Rev Neurocienc 2012;20:273-84. https://doi.org/10.34024/rnc.2012.v20.8280
25.Tosefsky KN, Zhu J, Wang YN, Lam JST, Cammalleri A, Appel-Cresswell S. The Role of Diet in Parkinson's Disease. J Parkinsons Dis 2024;14:S21-34. https://doi.org/10.3233/JPD-230264
26.Peters S, Gallo V, Vineis P, Middleton LT, Forsgren L, Sacerdote MD, et al. Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort. Desordem Mov 2020;35:1258-63. https://doi.org/10.1002/mds.28039
27.Molsberry S, Bjornevik K, Hughes KC, Healy B, Schwarzschild M, Ascherio A. Diet pattern and prodromal features of Parkinson disease. Neurology 2020;95:e2095-108. https://doi.org/10.1212/WNL.0000000000010523
28.Molsberry S, Bjornevik K, Hughes KC, Healy B, Schwarzschild M, Ascherio A. Diet pattern and prodromal features of Parkinson disease. Neurology 2020;95:e2095-108. https://doi.org/10.1212/WNL.0000000000010523
29.Liu YH, Jensen GL, Na M, Mitchell DC, Wood CGD, Still C, et al. Diet Quality and Risk of Parkinson's Disease: A Prospective Study and Meta-Analysis. J Parkinsons Dis 2021;11:337-47. https://doi.org/10.3233/JPD-202290
30.Seidl SE, Santiago JA, Bilyk H, Potashkin JA. The emerging role of nutrition in Parkinson’s disease. Front Aging Neurosci Nutr Parkinsons Dis 2014;6:36. https://doi.org/10.3389/fnagi.2014.00036
31.Kent G, Kehoe L, Flynn A, Walton J. Plant-based diets: a review of the definitions and nutritional role in the adult diet. Proc Nutr Soc 2022;81:62-74. https://doi.org/10.1017/S0029665121003839
32.McCarty MF. Does a vegan diet reduce risk for Parkinson's disease? Med Hypotheses 2001;57:318-23. https://doi.org/10.1054/mehy.2000.1321
Downloads
Publicado
Edição
Seção
Licença
Copyright (c) 2025 Raissa Dias Fernandez, Bruno Lopes do Santos Lobato

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
