Efeitos da microbiota intestinal na modulação do eixo cérebro intestino em transtornos neurológicos
DOI:
https://doi.org/10.34024/rnc.2025.v33.19985Palavras-chave:
Microbiota intestinal, Eixo cérebro-intestino, Transtornos neurológicosResumo
Introdução. O eixo intestino-cérebro conecta o ambiente gastrointestinal ao Sistema Nervoso Central (SNC), sendo crucial para a homeostase. Alterações nessa conexão estão associadas a distúrbios neuropsiquiátricos, como depressão e ansiedade, frequentemente ligados a comorbidades gastrointestinais. Objetivo. Explorar o papel da microbiota intestinal na regulação do eixo cérebro-intestino e suas contribuições para a compreensão e tratamento de transtornos neurológicos. Método. A pesquisa utilizou uma revisão integrativa da literatura com dados coletados de bases como PubMed e ScienceDirect. Foram selecionados artigos publicados entre 2014 e 2025, utilizando descritores como "Microbiota intestinal", "Eixo cérebro-intestino" e "Transtornos neurológicos”. Após a triagem, 17 estudos foram incluídos na análise. Resultados. Os estudos revisados indicam que a microbiota intestinal desempenha um papel crucial na regulação do eixo cérebro-intestino, influenciando transtornos neurológicos como depressão, Alzheimer e Parkinson. Alterações na microbiota afetam neurotransmissores e causam inflamações, sendo que, intervenções como: probióticos e dietas específicas, mostram-se promissoras. Tecnologias avançadas vêm ampliando o entendimento dessas interações, abrindo caminhos para novas abordagens terapêuticas. Conclusão. Este artigo destaca a relação entre a microbiota intestinal e o eixo cérebro-intestino, enfatizando que estilos de vida saudáveis e intervenções, como o uso de probióticos contribuem para a restauração do equilíbrio microbiano e a redução de processos neurodegenerativos.
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Copyright (c) 2025 Adrielly Oliveira Mateus, Anna Clara Bernardo Serra, Isadora Aires Godinho, Luiz Fernando Andrade , Maria Isabel Silva Moreira, Renata Rosa Carrilho de Castro Medeiros
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
