Disbiose intestinal e neurodegeneração: a relação intestino-cérebro na Doença de Alzheimer
DOI:
https://doi.org/10.34024/rnc.2025.v33.19757Palavras-chave:
eixo intestino-cérebro, microbiota intestinal, patogênese, doença de alzheimer, doenças neurodegenerativasResumo
Introdução. Diante da crescente compreensão da microbiota como um componente influente na saúde cerebral, neste estudo se propõe uma visão integrada do conhecimento, fornecendo uma análise da literatura disponível, uma vez que a Doença de Alzheimer (DA), marcada por neurodegeneração e neuroinflamação, apresenta desafios consideráveis no diagnóstico e tratamento. Além disso, com o aumento da proporção de idosos na população global, torna-se cada vez mais crucial compreender as interações eixo intestino-cérebro, a fim de investigar os mecanismos subjacentes e apresentar novas perspectivas terapêuticas. Objetivo. Analisar a relação entre a microbiota intestinal e os processos neurodegenerativos da Doença de Alzheimer, com ênfase na disbiose e sua interferência na regulação neural. Método. Foi realizada uma revisão bibliográfica integrativa com análise crítica de estudos sobre a relação entre a microbiota intestinal e a DA. No total, foram identificados 183 artigos, sendo 28 selecionados após aplicação de critérios de inclusão e exclusão. Resultados. Os estudos evidenciam a importância do intestino na regulação metabólica, imunológica e neural, destacando o eixo intestino-cérebro como via de comunicação bidirecional. A microbiota intestinal emerge como peça central no entendimento de doenças neurodegenerativas, influenciando processos inflamatórios e homeostáticos cerebrais. Conclusão. O eixo intestino-cérebro é uma via relevante para compreender os mecanismos subjacentes à DA, apontando a microbiota intestinal como potencial alvo para intervenções terapêuticas. Compreender essas interações é essencial para estratégias preventivas e para o desenvolvimento de tratamentos mais eficazes frente ao crescente impacto da DA na saúde pública global.
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Referências
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Copyright (c) 2025 Ingrid Tavares de Paula Teles, Maria Nathália Moraes, Anayana Cristina Pertile de Oliveira
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
