Speech-language and hearing disorders related to microcephaly
DOI:
https://doi.org/10.34024/rnc.2025.v33.19026Keywords:
Microcephaly, hearing, language, Speech Language Hearing Science, speech, DeglutitionAbstract
Introduction. In microcephaly there is a reduction in the occipitofrontal circumference of the head, being caused by several factors, among which are related to chemical and infectious substances, as well as irradiation, bacteria and viruses. Speech-language pathology enters as an active part in the orientation, stimulation and monitoring of rehabilitation in the processes arising from microcephaly. Objective. To describe possible speech-language pathology changes in individuals with microcephaly, through a literature review. Method. A bibliographic review regarding speech therapy in patients with microcephaly with regard to the pathological period since the subclinical phase (early diagnosis, treatment and limitation damage) to the stationary phase of the process to reduce the sequelae. Results. The speech-language disorders identified were variable and heterogeneous, it is not possible to establish a pattern of symptoms, but it is highlighted that in most cases there is a probability of at least one speech-language characteristic being present in this way. Conclusion. The study contributes to the understanding of language, hearing and orofacial myofunctional disorders in children with microcephaly, highlighting the deficits that are within the competence of the speech-language pathologist to assess, diagnose and intervene.
Metrics
References
Marques RS, Vasconcelos EC, Andrade RM, Hora IAA. Achados clínicos faciais em bebês com microcefalia. Odonto 2017;25:17-27. https://doi.org/10.15603/2176-1000/odonto.v25n49p17-27
Von der Hagen M, Pivarcsi M, Liebe J, von Bernuth H, Didonato N, Hennermann JB, et al. Diagnostic approach to microcephaly in childhood: a two-center study and review of the literature. Dev Med Child Neurol 2014;56:732-41. https://doi.org/10.1111/dmcn.12425
Nunez C, Morris A, Jones CA, Badawi N, Baynam G, Hansen M, et al. Microcephaly in Australian children, 2016-2018: national surveillance study. Arch Dis Child 2021:106:849-54. https://doi.org/10.1136/archdischild-2020-320456
Peloggia A, Ali M, Nanda K, Bahamondes L. Zika virus exposure in pregnancy and its association with newborn visual anomalies and hearing loss. Int J Gynaecol Obstet 2018;143:277-81. https://doi.org/10.1002/ijgo.12663
Lage MLC, Carvalho AL, Ventura PA, Taguchi TB, Fernandes AS, Pinho SF, et al. Clinical, neuroimaging, and neurophysiological findings in children with microcephaly related to congenital zika virus infection. Int J Environ Res Public Health 2019;16:309. https://doi.org/10.3390/ijerph16030309
Brito AF, Baldrighi SEZM. Repercussões fonoaudiológicas na síndrome de seckel: estudo de caso. Rev CEFAC 2015;17:1698-715. https://doi.org/10.1590/1982-021620151751914
Costello A, et al. Defining the syndrome associated with congenital Zika virus infection. Bull World Health Organ 2016;94:406. https://doi.org/10.2471/BLT.16.176990
Rosa BCS, Silva JF, Santos M, Lewis DR. Avaliação audiológica em criança com microcefalia pelo zika vírus: estudo de caso. Distúrb Comum 2018;30:357-63. https://doi.org/10.23925/2176-2724.2018v30i2p-357-363
Brasil. Ministério da Saúde. Secretaria de Atenção à Saúde. Diretrizes de Estimulação Precoce Crianças de zero a 3 anos com Atraso no Desenvolvimento Neuropsicomotor Decorrente de Microcefalia. Brasília: Ministério da Saúde; 2016. https://moodle.unasus.gov.br/vitrine29/pluginfile.php/5384/mod_resource/content/2/DIRETRIZES%20DE%20ESTIMULA%C3%87%C3%83O%20PRECOCE.pdf
Rosa BCS, César CPHAR, Paranhos LR, Guedes-Granzotti RB, Lewis DR. Speech-language disorders in children with congenital Zika virus syndrome: a systematic review. Int J Pediatr Otorhinolaryngol 2020;138:110309. https://doi.org/10.1016/j.ijporl.2020.110309
Cavalcanti AFC, Aguiar YPC, Melo ASO, Cavalcanti AL, D'Ávila S. Breastfeeding behavior in brazilian children with congenital zika syndrome. Int J Dent 2020;2020:1078250. https://doi.org/10.1155/2020/1078250
Faria JBC, Feitosa ALF, Canuto MSB. Achados miofuncionais orofaciais em crianças com microcefalia. Distúrb Comun 2020;32:462-9. https://doi.org/10.23925/2176-2724.2020v32i3p462-469
Stoler-Poria S, Lev D, Schweiger A, Lerman-Sagie T, Malinger G. Developmental outcome of isolated fetal microcephaly. Ultrasound Obstet Gynecol 2010;36:154-8. https://doi.org/10.1002/uog.7556
Aggarwal A, Mittal H, Patil R, Debnath S, Rai AJ. Clinical profile of children with developmental delay and microcephaly. Neurosci Rural Pract 2013;4:288-91. https://doi.org/10.4103/0976-3147.118781
Nakashima M, Takano K, Osaka H, Aida N, Tsurusaki Y, Miyake N, et al. Causative novel PNKP mutations and concomitant PCDH15 mutations in a patient with microcephaly with early-onset seizures and developmental delay syndrome and hearing loss. J Hum Genet 2014;59:471-4. https://doi.org/10.1038/jhg.2014.51
Li MH, Arndt K, Das S, Weiss EM, Wu Y, Gwal K, et al. Compound heterozygote CDK5RAP2 mutations in a Guatemalan/Honduran child with autosomal recessive primary microcephaly, failure to thrive and speech delay. Am J Med Genet A 2015;167:1414-7. https://doi.org/10.1002/ajmg.a.36975
Tanaka AJ, Cho MT, Millan F, Juusola J, Retterer K, Joshi C, et al. Mutations in SPATA5 Are Associated with Microcephaly, Intellectual Disability, Seizures, and Hearing Loss. Am J Hum Genet 2015;97:457-64. https://doi.org/10.1016/j.ajhg.2015.07.014
Ji J, Lee H, Argiropoulos B, Dorrani N, Mann J, Martinez-Agosto JA, et al. DYRK1A haploinsufficiency causes a new recognizable syndrome with microcephaly, intellectual disability, speech impairment, and distinct facies. Eur J Hum Genet 2015;23:1473-81. https://doi.org/10.1038/ejhg.2015.71
Leal MC, Muniz LF, Ferreira TS, Santos CM, Almeida LC, Van Der Linden V, et al. Hearing Loss in Infants with Microcephaly and Evidence of Congenital Zika Virus Infection - Brazil, November 2015-May 2016. MMWR Morb Mortal Wkly Rep 2016;65:917-9. https://doi.org/10.15585/mmwr.mm6534e3
Leal MC, van der Linden V, Bezerra TP, Valois L, Borges ACG, Antunes MMC, et al. Characteristics of dysphagia in infants with microcephaly caused by congenital zika virus infection, Brazil, 2015. Emerg Infect Dis 2017;23:1253-9. https://doi.org/10.3201/eid2308.170354
Fonteles CSR, Ribeiro EM, Santos MSA, Leite RFP, Assunção GS, Monteiro AJ, et al. Lingual frenulum phenotypes in brazilian infants with Congenital Zika Syndrome. Cleft Palate Craniofac J 2018;55:1391-8. https://doi.org/10.1177/1055665618766999
Fandiño-Cárdenas M1, Idrovo AJ, Velandia R, Molina-Franky J, Alvarado-Socarras JL. Zika virus infection during pregnancy and sensorineural hearing loss among children at 3 and 24 months post-partum. J Tropical Pediatrics 2019;65:328-35. https://doi.org/10.1093/tropej/fmy055
Almeida KJ, Martins ACB, Almendra ICCG, Meneses GMS, Sampaio TDO, Campêlo JCM, et al. Clinical aspects of congenital microcephaly syndrome by Zika virus in a rehabilitation center for patients with microcephaly. Rev Assoc Med Bras 2019;65:1249-53. https://doi.org/10.1590/1806-9282.65.10.1249
Almeida LC, Muniz LF, Maciel RJ, Ramos DS, Albuquerque KMG, Leão ÂMC, et al. Hearing and communicative skills in the first years of life in children with congenital Zika syndrome. Braz J Otorhinolaryngol 2022;88:112-7. https://doi.org/10.1016/j.bjorl.2020.05.007
Barbosa MHM, Garcia CFD, Magalhães Barbosa MC, Robaina JR, Prata-Barbosa A, Lima MAMT, et al. Normal Hearing Function in Children Prenatally Exposed to Zika Virus. Int Arch Otorhinolaryngol 2020;24:e299-307. https://doi.org/10.1055/s-0039-3399539
Cranston JS, Tiene SF, Nielsen-Saines K, Vasconcelos Z, Pone MV, Pone S, et al. Association Between Antenatal Exposure to Zika Virus and Anatomical and Neurodevelopmental Abnormalities in Children. JAMA Netw Open 2020;3:e209303. https://doi.org/10.1001/jamanetworkopen.2020.9303
WHO: World Health Organization (Internet). Geneva: WHO; 2021. Disponível em: http://www.who.int/en/
The Joint Committee of Infant Hearing (JCIH). Year 2019 Position statement: principles and guidelines for early hearing detection and intervention programs. J Early Hearing Detc Interv 2019;4:1-44. https://www.audiology.org/wp-content/uploads/2021/06/JCIH-2019.pdf
Brunoni D, Blascovi-Assis SM, Osório AA, Seabra AG, Amato CA, Teixeira MC, et al. Microcefalia e outras manifestações relacionadas ao vírus Zika: impacto nas crianças, nas famílias e nas equipes de saúde. Cien Saude Colet 2016;21:3297-302. https://doi.org/10.1590/1413-812320152110.16832016
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Caroline Pascon, Roseane Silva de Almeida, Dalva Maria Batista de Souza, Cindy Rafaella Lira Silva, Willian Santos da Silva, Maria Gabriela Cavalheiro , Luciana Paula Maximino, Camila de Castro Corrêa

This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
Accepted 2025-02-12
Published 2025-02-25
