Irisin, a myocin as therapy for Alzheimer's Disease: integrative review
DOI:
https://doi.org/10.34024/rnc.2024.v32.18794Keywords:
Alzheimer's disease, Myokines, BDNF, Type III Fibronectin DomainAbstract
Introduction. Alzheimer's disease (AD) is neurodegenerative, prevalent and serious. The presence of sensitive amyloid plaques (Aβ) is one of the main causes of AD. Studies show that Irisin, a myokine, produced through muscle contraction, from the cleavage of fibronectin type III with domain 5 (FNDC5) can reduce AD disorders. Objective. To highlight studies that demonstrate the benefits of Irisin and its action in AD. Method. The following databases were used: Pubmed, Scopus, Science Direct and VHL. Results. A total of 182 articles were identified, and after reading and analysis, 19 met the inclusion criteria in this review. Conclusion. After analyzing the studies, it is clear that irisin is promising for the treatment and prevention of AD. It can be concluded that the effects of irisin in AD are beneficial, but more investigative studies in humans are needed to better develop a possible therapy.
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Copyright (c) 2024 Vinícius Antonio da Silva Martins, Cláudia Maria Dias Moreira, Eduardo dos Santos Garcia, Alcione Lescano de Souza Junior
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Accepted 2024-08-14
Published 2024-08-28
