Perfil clínico de pacientes com Síndrome de Guillain Barré em um hospital de Santa Catarina
DOI:
https://doi.org/10.34024/rnc.2024.v32.16353Palavras-chave:
Síndrome de Guillain-Barré, Neutrófilos, Dissociação Proteico-citológica, Imunoglobulina intravenosaResumo
Introdução. A síndrome de Guillain-Barré (SGB) pode ser definida como uma polirradiculoneuropatia inflamatória de origem autoimune, caracterizada pelo aparecimento de paresia e parestesia ascendentes e progressivas. Objetivo. Conhecer o perfil clínico e epidemiológico de pacientes diagnosticados com a SGB em um hospital do Sul de Santa Catarina. Método. Foi realizado um estudo epidemiológico observacional de delineamento transversal com uso de dados secundários. Resultados. Foram analisados 33 prontuários de pacientes diagnosticados com a SGB, dos quais 57,6% pertenciam ao sexo masculino e de etnia branca (94%). Observou-se que apenas 36,4% dos pacientes não obtiveram alta hospitalar após duas semanas, complicações foram encontradas em até 84,8% dos casos, apresentando estreita relação com a dissociação proteico-citológica e com a elevação das populações de neutrófilos. A imunoglobulina intravenosa corresponde ao método de tratamento instituído para 69,7% dos pacientes. Conclusão. A relação das concentrações séricas de neutrófilos parece expressar intrínseca relação com a evolução da condição em estudo. Além disso, seu manejo com a imunoglobulina representa o método mais bem estabelecido para o controle da evolução dos sintomas sensitivo-motores.
Métricas
Referências
Nakano Y, Kanda T. Pathology of the Peripheral Nervous System in Guillain-Barré Syndrome. Brain Nerve 2015;67:1329-39. https://doi.org/10.11477/mf.1416200303
Van Den Berg B, Walgaard C, Drenthen J, Fokke C, Jacobs BC, Van Doorn PA. Guillain-Barré syndrome: pathogenesis, diagnosis, treatment and prognosis. Nat Rev Neurol 2014;10:469-82. https://doi.org/10.1038/nrneurol.2014.121
Wijdicks EFM, Klein CJ. Guillain-Barré Syndrome. Mayo Clin Proc 2017;92:467-79. https://doi.org/10.1016/j.mayocp.2016.12.002
Koike H, Chiba A, Katsuno M. Emerging Infection, Vaccination, and Guillain-Barré Syndrome: A Review. Neurol Ther 2021;10:523-37. https://doi.org/10.1007/s40120-021-00261-4
Liu S, Dong C, Ubogu EE. Immunotherapy of Guillain-Barré syndrome. Hum Vaccin Immunother 2018;14:2568-79. https://doi.org/10.1080/21645515.2018.1493415
Berciano J. Axonal pathology in early stages of Guillain-Barré syndrome. Neurologia 2022;37:466-79. https://doi.org/10.1016/j.nrl.2018.06.002
Shahrizaila N, Lehmann HC, Kuwabara S. Guillain-Barré syndrome. Lancet 2021;397:1214-28. https://doi.org/10.1016/S0140-6736(21)00517-1
Lleixà C, Martín-Aguilar L, Pascual-Goñi E, Franco T, Caballero M, de Luna N, et al. Autoantibody screening in Guillain-Barré syndrome. J Neuroinflammation 2021;18:251. https://doi.org/10.1186/s12974-021-02301-0
Shahrizaila N, Lehmann HC, Kuwabara S. Guillain-Barré syndrome. Lancet 2021;397:1214-28. https://doi.org/10.1016/S0140-6736(21)00517-1
Malek E, Salameh J. Guillain-Barre Syndrome. Seminars in Neurology 2019;39:589-95. https://doi.org/10.1055/s-0039-1693005
Marcus R. What Is Guillain-Barré Syndrome? JAMA 2023;329:602. https://doi.org/10.1001/jama.2022.24232
Doets AY, Hughes RA, Brassington R, Hadden RD, Pritchard J. Pharmacological treatment other than corticosteroids, intravenous immunoglobulin and plasma exchange for Guillain-Barré syndrome. Cochrane Database Syst Rev 2020;1:CD008630. https://doi.org/10.1002/14651858.CD008630.pub5
Ethemoglu O, Calik M. Effect of serum inflammatory markers on the prognosis of adult and pediatric patients with Guillain-Barré syndrome. Neuropsychiatr Dis Treat 2018;14:1255-60. https://doi.org/10.2147/NDT.S162896
Leonhard SE, Bresani-Salvi CC, Lyra Batista JD, Cunha S, Jacobs BC, Brito Ferreira ML, et al. Guillain-Barré syndrome related to Zika virus infection: A systematic review and meta-analysis of the clinical and electrophysiological phenotype. PLOS Neglected Trop Dis 2020;14:e0008264. https://doi.org/10.1371/journal.pntd.0008264
Yadegari S, Nafissi S, Kazemi N. Comparison of electrophysiological findings in axonal and demyelinating Guillain-Barre syndrome. Iran J Neurol 2014;13:138-43. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240930/
Vargas-Cañas ES, Galnares-Olalde JA, León-Velasco F, García-Grimshaw M, Gutiérrez A, López-Hernández JC. Prognostic Implications of Early Albuminocytological Dissociation in Guillain-Barré Syndrome. Can J Neurol Sci 2023;50:745-50. https://doi.org/10.1017/cjn.2022.288
Jahan I, Ahmed R, Ahmed J, Khurshid S, Biswas PP, Upama IJ, et al. Neutrophil-lymphocyte ratio in Guillain-Barré syndrome: A prognostic biomarker of severe disease and mechanical ventilation in Bangladesh. JPNS 2023;28:47-57. https://doi.org/10.1111/jns.12531
Sarejloo S, Khanzadeh S, Hosseini S, Gargari MK, Lucke-Wold B, Mosalamiaghili S, et al. Role of the Neutrophil to Lymphocyte Ratio in Guillain Barré Syndrome: A Systematic Review and Meta-Analysis. Yin G, editor. Mediators Inflamm 2022;2022:1-13. https://doi.org/10.1111/jns.12531
Kalita J, Misra UK, Chaudhary SK, Das M, Mishra A, Ranjan A, et al. Outcome of Guillain–Barré syndrome following intravenous immunoglobulin compared to natural course. Eur J Neurol 2022;29:3071-80. https://doi.org/10.1111/ene.15500
Walgaard C, Jacobs BC, Lingsma HF, Steyerberg EW, van den Berg B, Doets AY, et al. Second intravenous immunoglobulin dose in patients with Guillain-Barré syndrome with poor prognosis (SID-GBS): a double-blind, randomised, placebo-controlled trial. Lancet Neurol 2021;20:275-83. https://doi.org/10.1016/S1474-4422(20)30494-4
Gevorgyan A, Sanossian N, Beydoun SR. Guillain-Barré Syndrome Trend of Hospital Length of Stay, Complication Rate and Mortality Depending from Method of the Treatment: IVIg vs. PLEX (P5.137). Neurology 2017;88(16 Supplement):79758331. https://doi.org/10.1212/WNL.88.16_supplement.P5.137
Ginanneschi F, Giannini F, Sicurelli F, Battisti C, Capoccitti G, Bartalini S, et al. Clinical Features and Outcome of the Guillain–Barre Syndrome: A Single-Center 11-Year Experience. Front Neurol 2022;13:856091. https://doi.org/10.3389/fneur.2022.856091
Bentley SA, Ahmad S, Kobeissy FH, Toklu HZ. Concomitant Guillain–Barré Syndrome and COVID-19: A Meta-Analysis of Cases. Medicina 2022;58:1835. https://doi.org/10.3390/medicina58121835
Fernandez P, Pereira JM, Risso IS, Silva PA, Caroline I, Vieira G, et al. Guillain‐Barre syndrome following COVID‐19 vaccines: A scoping review. Acta Neurol Scan 2021;145:393-8. https://doi.org/10.1111/ane.13575
Lupu VV, Miron I, Cianga AL, Gavrilovici C, Grigore I, David AG, et al. Diagnostic Pitfalls in Guillain–Barré Syndrome: Case Report and Literature Review. Children 2022;9:1969. https://doi.org/10.3390/children9121969
Pimentel V, Luchsinger VW, Carvalho GL, Alcará AM, Esper NB, Marinowic D, et al. Guillain–Barré syndrome associated with COVID-19: A systematic review. Brain Behav Immun Health 2023;28:100578. https://doi.org/10.1016/j.bbih.2022.100578
Yi SW, Lee JH, Hong JM, Choi YC, Park HJ. Incidence, Disability, and Mortality in Patients With Guillain-Barré Syndrome in Korea: A Nationwide Population-Based Study. J Clin Neurol 2022;18:48-58. https://doi.org/10.3988/jcn.2022.18.1.48
Capasso A, Ompad DC, Vieira DL, Wilder-Smith A, Tozan Y. Incidence of Guillain-Barré Syndrome (GBS) in Latin America and the Caribbean before and during the 2015–2016 Zika virus epidemic: A systematic review and meta-analysis. PLOS Neglected Trop Dis 2019;13:e0007622. https://doi.org/10.1371/journal.pntd.0007622
Martín-Aguilar L, Camps-Renom P, Lleixà C, Pascual-Goñi E, Díaz-Manera J, Rojas-García R, et al. Serum neurofilament light chain predicts long-term prognosis in Guillain-Barré syndrome patients. J Neurol Neuros Psychiatr 2020;2020:323899. https://doi.org/10.1136/jnnp-2020-323899
Cao Y, Ji S, Chen Y, Zhang X, Ding G, Tang F. Association between autoimmune diseases of the nervous system and schizophrenia: A systematic review and meta-analysis of cohort studies. Compreh Psychiatr 2023;122:152370. https://doi.org/10.1016/j.comppsych.2023.152370
Downloads
Publicado
Edição
Seção
Licença
Copyright (c) 2024 Pedro Henrique Rocha Zin, Jucélia Jeremias Fortunato
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
