Clinical profile of patients with Guillain Barré Syndrome in a hospital of Santa Catarina

Authors

DOI:

https://doi.org/10.34024/rnc.2024.v32.16353

Keywords:

Guillain-Barré syndrome, Neutrophils, Protein-cytological dissociation, intravenous immunoglobulin

Abstract

Introduction. Guillain-Barré syndrome (GBS) can be defined as an inflammatory polyradiculoneuropathy of autoimmune origin, characterized by the onset of ascending and progressive paresis and paresthesia. Objective. To know the clinical and epidemiological profile of patients diagnosed with GBS in a hospital in the south of Santa Catarina. Method. An observational epidemiological study with a cross-sectional design was carried out using secondary data. Results. 33 medical records of patients diagnosed with GBS were analyzed, of which 57.6% were male and white (94%). It was observed that only 36.4% of patients were not discharged after two weeks, complications were found in up to 84.8% of cases, showing a close relationship with protein-cytological dissociation and with the increase in neutrophil populations. Intravenous immunoglobulin corresponds to the treatment method established for 69.7% of patients. Conclusion. The relationship between serum concentrations of neutrophils seems to express an intrinsic relationship with the evolution of the condition under study. In addition, its management with immunoglobulin represents the best-established method for controlling the evolution of sensory-motor symptoms.

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References

Nakano Y, Kanda T. Pathology of the Peripheral Nervous System in Guillain-Barré Syndrome. Brain Nerve 2015;67:1329-39. https://doi.org/10.11477/mf.1416200303

Van Den Berg B, Walgaard C, Drenthen J, Fokke C, Jacobs BC, Van Doorn PA. Guillain-Barré syndrome: pathogenesis, diagnosis, treatment and prognosis. Nat Rev Neurol 2014;10:469-82. https://doi.org/10.1038/nrneurol.2014.121

Wijdicks EFM, Klein CJ. Guillain-Barré Syndrome. Mayo Clin Proc 2017;92:467-79. https://doi.org/10.1016/j.mayocp.2016.12.002

Koike H, Chiba A, Katsuno M. Emerging Infection, Vaccination, and Guillain-Barré Syndrome: A Review. Neurol Ther 2021;10:523-37. https://doi.org/10.1007/s40120-021-00261-4

Liu S, Dong C, Ubogu EE. Immunotherapy of Guillain-Barré syndrome. Hum Vaccin Immunother 2018;14:2568-79. https://doi.org/10.1080/21645515.2018.1493415

Berciano J. Axonal pathology in early stages of Guillain-Barré syndrome. Neurologia 2022;37:466-79. https://doi.org/10.1016/j.nrl.2018.06.002

Shahrizaila N, Lehmann HC, Kuwabara S. Guillain-Barré syndrome. Lancet 2021;397:1214-28. https://doi.org/10.1016/S0140-6736(21)00517-1

Lleixà C, Martín-Aguilar L, Pascual-Goñi E, Franco T, Caballero M, de Luna N, et al. Autoantibody screening in Guillain-Barré syndrome. J Neuroinflammation 2021;18:251. https://doi.org/10.1186/s12974-021-02301-0

Shahrizaila N, Lehmann HC, Kuwabara S. Guillain-Barré syndrome. Lancet 2021;397:1214-28. https://doi.org/10.1016/S0140-6736(21)00517-1

Malek E, Salameh J. Guillain-Barre Syndrome. Seminars in Neurology 2019;39:589-95. https://doi.org/10.1055/s-0039-1693005

Marcus R. What Is Guillain-Barré Syndrome? JAMA 2023;329:602. https://doi.org/10.1001/jama.2022.24232

Doets AY, Hughes RA, Brassington R, Hadden RD, Pritchard J. Pharmacological treatment other than corticosteroids, intravenous immunoglobulin and plasma exchange for Guillain-Barré syndrome. Cochrane Database Syst Rev 2020;1:CD008630. https://doi.org/10.1002/14651858.CD008630.pub5

Ethemoglu O, Calik M. Effect of serum inflammatory markers on the prognosis of adult and pediatric patients with Guillain-Barré syndrome. Neuropsychiatr Dis Treat 2018;14:1255-60. https://doi.org/10.2147/NDT.S162896

Leonhard SE, Bresani-Salvi CC, Lyra Batista JD, Cunha S, Jacobs BC, Brito Ferreira ML, et al. Guillain-Barré syndrome related to Zika virus infection: A systematic review and meta-analysis of the clinical and electrophysiological phenotype. PLOS Neglected Trop Dis 2020;14:e0008264. https://doi.org/10.1371/journal.pntd.0008264

Yadegari S, Nafissi S, Kazemi N. Comparison of electrophysiological findings in axonal and demyelinating Guillain-Barre syndrome. Iran J Neurol 2014;13:138-43. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240930/

Vargas-Cañas ES, Galnares-Olalde JA, León-Velasco F, García-Grimshaw M, Gutiérrez A, López-Hernández JC. Prognostic Implications of Early Albuminocytological Dissociation in Guillain-Barré Syndrome. Can J Neurol Sci 2023;50:745-50. https://doi.org/10.1017/cjn.2022.288

Jahan I, Ahmed R, Ahmed J, Khurshid S, Biswas PP, Upama IJ, et al. Neutrophil-lymphocyte ratio in Guillain-Barré syndrome: A prognostic biomarker of severe disease and mechanical ventilation in Bangladesh. JPNS 2023;28:47-57. https://doi.org/10.1111/jns.12531

Sarejloo S, Khanzadeh S, Hosseini S, Gargari MK, Lucke-Wold B, Mosalamiaghili S, et al. Role of the Neutrophil to Lymphocyte Ratio in Guillain Barré Syndrome: A Systematic Review and Meta-Analysis. Yin G, editor. Mediators Inflamm 2022;2022:1-13. https://doi.org/10.1111/jns.12531

Kalita J, Misra UK, Chaudhary SK, Das M, Mishra A, Ranjan A, et al. Outcome of Guillain–Barré syndrome following intravenous immunoglobulin compared to natural course. Eur J Neurol 2022;29:3071-80. https://doi.org/10.1111/ene.15500

Walgaard C, Jacobs BC, Lingsma HF, Steyerberg EW, van den Berg B, Doets AY, et al. Second intravenous immunoglobulin dose in patients with Guillain-Barré syndrome with poor prognosis (SID-GBS): a double-blind, randomised, placebo-controlled trial. Lancet Neurol 2021;20:275-83. https://doi.org/10.1016/S1474-4422(20)30494-4

Gevorgyan A, Sanossian N, Beydoun SR. Guillain-Barré Syndrome Trend of Hospital Length of Stay, Complication Rate and Mortality Depending from Method of the Treatment: IVIg vs. PLEX (P5.137). Neurology 2017;88(16 Supplement):79758331. https://doi.org/10.1212/WNL.88.16_supplement.P5.137

Ginanneschi F, Giannini F, Sicurelli F, Battisti C, Capoccitti G, Bartalini S, et al. Clinical Features and Outcome of the Guillain–Barre Syndrome: A Single-Center 11-Year Experience. Front Neurol 2022;13:856091. https://doi.org/10.3389/fneur.2022.856091

Bentley SA, Ahmad S, Kobeissy FH, Toklu HZ. Concomitant Guillain–Barré Syndrome and COVID-19: A Meta-Analysis of Cases. Medicina 2022;58:1835. https://doi.org/10.3390/medicina58121835

Fernandez P, Pereira JM, Risso IS, Silva PA, Caroline I, Vieira G, et al. Guillain‐Barre syndrome following COVID‐19 vaccines: A scoping review. Acta Neurol Scan 2021;145:393-8. https://doi.org/10.1111/ane.13575

Lupu VV, Miron I, Cianga AL, Gavrilovici C, Grigore I, David AG, et al. Diagnostic Pitfalls in Guillain–Barré Syndrome: Case Report and Literature Review. Children 2022;9:1969. https://doi.org/10.3390/children9121969

Pimentel V, Luchsinger VW, Carvalho GL, Alcará AM, Esper NB, Marinowic D, et al. Guillain–Barré syndrome associated with COVID-19: A systematic review. Brain Behav Immun Health 2023;28:100578. https://doi.org/10.1016/j.bbih.2022.100578

Yi SW, Lee JH, Hong JM, Choi YC, Park HJ. Incidence, Disability, and Mortality in Patients With Guillain-Barré Syndrome in Korea: A Nationwide Population-Based Study. J Clin Neurol 2022;18:48-58. https://doi.org/10.3988/jcn.2022.18.1.48

Capasso A, Ompad DC, Vieira DL, Wilder-Smith A, Tozan Y. Incidence of Guillain-Barré Syndrome (GBS) in Latin America and the Caribbean before and during the 2015–2016 Zika virus epidemic: A systematic review and meta-analysis. PLOS Neglected Trop Dis 2019;13:e0007622. https://doi.org/10.1371/journal.pntd.0007622

Martín-Aguilar L, Camps-Renom P, Lleixà C, Pascual-Goñi E, Díaz-Manera J, Rojas-García R, et al. Serum neurofilament light chain predicts long-term prognosis in Guillain-Barré syndrome patients. J Neurol Neuros Psychiatr 2020;2020:323899. https://doi.org/10.1136/jnnp-2020-323899

Cao Y, Ji S, Chen Y, Zhang X, Ding G, Tang F. Association between autoimmune diseases of the nervous system and schizophrenia: A systematic review and meta-analysis of cohort studies. Compreh Psychiatr 2023;122:152370. https://doi.org/10.1016/j.comppsych.2023.152370

Published

2024-07-10

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Artigos Originais

How to Cite

1.
Rocha Zin PH, Jeremias Fortunato J. Clinical profile of patients with Guillain Barré Syndrome in a hospital of Santa Catarina. Rev Neurocienc [Internet]. 2024 Jul. 10 [cited 2025 Dec. 13];32:1-30. Available from: https://periodicos.unifesp.br/index.php/neurociencias/article/view/16353
Received 2024-02-19
Accepted 2024-05-21
Published 2024-07-10