Neuroinflamação Hipocampal e Distúrbios de memória na Síndrome Pós-COVID-19
DOI:
https://doi.org/10.34024/rnc.2024.v32.16138Palavras-chave:
Névoa cerebral, Neuroinflamação, Repercussões neurocognitivas, Síndrome Pós-COVID-19Resumo
Introdução. Este artigo aborda as implicações neurocognitivas da síndrome pós-COVID-19, com ênfase na neuroinflamação hipocampal e seu possível impacto nos distúrbios de memória. Explorando as evidências existentes sobre a relação entre a infecção por COVID-19 e as alterações neurocognitivas, busca-se aprofundar a compreensão desses fenômenos, destacando a importância de pesquisas mais detalhadas nesse campo crítico da saúde neurológica. Objetivo. Analisar as repercussões neurocognitivas na síndrome pós-COVID-19, com foco específico na neuroinflamação hipocampal e distúrbios de memória, visando aprofundar a compreensão dos mecanismos patológicos associados. Método. A pesquisa foi conduzida utilizando estratégias de busca em bases de dados como MEDLINE/PubMed, Science Direct e Web of Science. Os termos de busca seguiram padrões MeSH e DeCS. A questão norteadora foi sobre o impacto da síndrome pós-COVID-19 nas funções neurocognitivas, com foco na neuroinflamação hipocampal e distúrbios de memória. Resultados. A ativação microglial no hipocampo, associada ao comprometimento cognitivo por vírus, pode explicar sintomas neuropsiquiátricos em sobreviventes de COVID-19. Estudos indicam que a inflamação sistêmica, presente na sepse grave, pode desencadear comprometimento cognitivo e neurodegeneração, possivelmente compartilhando semelhanças com a COVID-19. Conclusão. Compreender as lesões cerebrais causadas pela COVID-19 pode guiar intervenções terapêuticas, incluindo moduladores de citocinas, para mitigar queixas neuropsiquiátricas. Melhorar as complicações pós-COVID-19 reduzirá o impacto da doença, enquanto a neuropatologia pode fornecer insights valiosos para outras condições neurodegenerativas.
Métricas
Referências
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Copyright (c) 2024 Jean Carlos Souza Silva, Dayane Pessoa de Araújo, Carlos Hermano da Justa Pinheiro, Ariclécio Cunha de Oliveira
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Aprovado 2024-07-30
Publicado 2024-08-14
