Co-factors associated with microcephaly of babies in pregnant women with Zika: an integrative review
DOI:
https://doi.org/10.34024/rnc.2024.v32.16056Keywords:
ZIKA virus infection, Microcephaly, Pregnant women, Environmental factors, GeneticsAbstract
Introduction. After the outbreak of microcephaly in babies associated with infection of pregnant women by the ZIKA virus in 2015 in northeastern Brazil, there was a great scientific search to understand this relationship. It is observed that about 3% of infected pregnant women have congenital ZIKA virus syndrome and an even smaller portion of those affected have microcephaly as a symptom. Considering this scenario, it is believed that other factors coexist with the infection. Objective. To evaluate the possible existence of factors associated with congenital Zika virus infection that leads to the development of microcephaly. Method. a search was carried out on indexed journal websites such as "Scielo" and "PubMed" considering the descriptors to find other factors that could be associated with microcephaly between 2015-2022. Ten articles were selected to prepare the integrative review. Results. The main findings were that environmental factors such as cyanobacterial toxins in daily drinking water and the use of larvicides increase the possibility of developing microcephaly when infected with ZIKA virus. Furthermore, genetic predispositions of the fetus associated with impaired functioning of immune system genes are also associated with the outcome of microcephaly when pregnant women are infected. Conclusion. There is still a lack of studies on these associations and that to date, in addition to individual care for pregnant women to avoid ZIKA virus infection, there are other factors that need to be considered.
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References
Dick GW, Kitchen S, Haddow A. Zika Virus (I). Isolations and serological specificity. Trans R Soc Trop Med Hyg 1952;46:509-20. https://doi.org/10.1016/0035-9203(52)90042-4
Chouin-Carneiro T, Vega-Rua A, Vazeille M, Yebakima A, Girod R, Goindin D, et al. Differential Susceptibilities of Aedes aegypti and Aedes albopictus from the Americas to Zika Virus. PLoS Negl Trop Dis 2016;10:e0004543. https://doi.org/10.1371/journal.pntd.0004543
Guedes DR, Paiva MH, Donato MM, Barbosa PP, Krokovsky L, Rocha SWS, et al. Zika virus replication in the mosquito Culex quinquefasciatus in Brazil. Emerg Microbes Infect 2017;6:1-11. https://doi.org/10.1038/emi.2017.59
Epelboin Y, Talaga S, Epelboin L, Dusfour I. Zika virus: An updated review of competent or naturally infected mosquitoes. PLoS Negl Trop Dis 2017;11:e0005933. https://doi.org/10.1371/journal.pntd.0005933
Basu R, Tumban E. Zika Virus on a Spreading Spree: what we now know that was unknown in the 1950’s. Virol J 2016;13:165. http://doi.org/10.1186/s12985-016-0623-2
Foy BD, Kobylinski KC, Foy JLC, Blitvich BJ, Travassos da Rosa A, Haddow AD, et al. Probable Non–Vector-borne Transmission of Zika Virus, Colorado, USA. Emerg Infect Dis 2011;17:880-2. http://doi.org/10.3201/eid1705.101939
Pereira-Silva JW, Nascimento VA, Belchior HCM, Almeida JF, Pessoa FAC, Naveca FG, et al. First evidence of Zika virus venereal transmission in Aedes aegypti mosquitoes. Mem Inst Oswaldo Cruz 2017;113:56-61. https://doi.org/10.1590/0074-02760170329
Carlson CJ, Dougherty ER, Getz W. An Ecological Assessment of the Pandemic Threat of Zika Virus. PLoS Negl Trop Dis 2016;10:e0004968. https://doi.org/10.1371/journal.pntd.0004968
Noorbakhsh F, Abdolmohammadi K, Fatahi Y, Dalili H, Rasoolinejad M, Rezaei F, et al. Zika Virus Infection, Basic and Clinical Aspects: A Review Article. Iran J Public Health 2019;48:20-31. http://www.ncbi.nlm.nih.gov/pubmed/30847308
França GVA, Schuler-Faccini L, Oliveira WK, Henriques CMP, Carmo EH, Pedi VD, et al. Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. Lancet 2016;388:891-7. https://doi.org/10.1016/S0140-6736(16)30902-3
Adibi JJ, Marques ETA, Cartus A, Beigi RH. Teratogenic effects of the Zika virus and the role of the placenta. Lancet 2016;387:1587-90. https://doi.org/10.1016/S0140-6736(16)00650-4
Miranda-Filho DB, Martelli CMT, Ximenes RAA, Araújo TVB, Rocha MAW, Ramos RCF, et al. Initial Description of the Presumed Congenital Zika Syndrome. Am J Public Health 2016;106:598-600. https://doi.org/10.2105/AJPH.2016.303115
Cauchemez S, Besnard M, Bompard P, Dub T, Guillemette-Artur P, Eyrolle-Guignot D, et al. Association between Zika virus and microcephaly in French Polynesia, 2013–15: a retrospective study. Lancet 2016;387:2125-32. https://doi.org/10.1016/S0140-6736(16)00651-6
Teixeira MG, Conceição N, Costa M, Oliveira WK, Nunes ML, Rodrigues LC. The Epidemic of Zika Virus–Related Microcephaly in Brazil: Detection, Control, Etiology, and Future Scenarios. Am J Public Health 2016;106:601-5. https://doi,org/10.2105/AJPH.2016.303113
Ministério da Saúde (BR). Situação epidemiológica de ocorrência de microcefalias no Brasil, 2015. Bol Epidemiológico 2015;46:1-3. https://repositorio.ipea.gov.br/bitstream/11058/8282/1/td_2368.pdf
Gulland A. Zika virus is a global public health emergency, declares WHO. BMJ 2016;352:i657. https://doi.org/10.1136/bmj.i657
Ministério da Saúde (BR). Microcefalia. 2023. Disponível em: https://www.gov.br/saude/pt-br/assuntos/saude-de-a-a-z/m/microcefalia
Quintans MDS, Bueno AC, Cardoso CAA. Microcephaly caused by or associated with congenital infections in the last 20 years in Brazil: a systematic review. Rev Inst Med Trop Sao Paulo 2022;64:e7. https://doi.org/10.1590/S1678-9946202264007
Hanzlik E, Gigante J. Microcephaly. Children 2017;4:47. https://doi.org/10.3390/children4060047
Schuler-Faccini L, Ribeiro EM, Feitosa IML, Horovitz DDG, Cavalcanti DP, Pessoa A, et al. Possible Association Between Zika Virus Infection and Microcephaly - Brazil, 2015. MMWR Morb Mortal Wkly Rep 2016;65:59-62. https://doi.org/10.15585/mmwr.mm6503e2
Cugola FR, Fernandes IR, Russo FB, Freitas BC, Dias JLM, Guimarães KP, et al. The Brazilian Zika virus strain causes birth defects in experimental models. Nature 2016;534:267-71. https://doi.org/10.1038/nature18296
Garcez PP, Nascimento JM, Vasconcelos JM, Madeiro da Costa R, Delvecchio R, Trindade P, et al. Zika virus disrupts molecular fingerprinting of human neurospheres. Sci Rep 2017;7:40780. https://doi.org/10.1038/srep40780
Butler D. Brazil asks whether Zika acts alone to cause birth defects. Nature 2016;535:475-6. https://doi.org/10.1038/nature.2016.20309
Coelho A, Crovella S. Microcephaly Prevalence in Infants Born to Zika Virus-Infected Women: A Systematic Review and Meta-Analysis. Int J Mol Sci 2017;18:1714. https://doi.org/10.3390/ijms18081714
Lobkowicz L, Miranda-Filho DB, Montarroyos UR, Martelli CMT, Araújo TVB, Souza WV, et al. Co-circulation of Chikungunya Virus during the 2015–2017 Zika Virus Outbreak in Pernambuco, Brazil: An Analysis of the Microcephaly Epidemic Research Group Pregnancy Cohort. Am J Trop Med Hyg 2022;106:1711-20. https://doi.org/10.4269/ajtmh.21-0449
Campos MC, Dombrowski JG, Phelan J, Marinho CRF, Hibberd M, Clark TG, et al. Zika might not be acting alone: Using an ecological study approach to investigate potential co-acting risk factors for an unusual pattern of microcephaly in Brazil. PLoS One 2018;13:e0201452. https://doi.org/10.1371/journal.pone.0201452
Gregianini TS, Ranieri T, Favreto C, Nunes ZMA, Tumioto Giannini GL, Sanberg ND, et al. Emerging arboviruses in Rio Grande do Sul, Brazil: Chikungunya and Zika outbreaks, 2014‐2016. Rev Med Virol 2017;27:1-10. https://doi.org/10.1002/rmv.1943
Petzold S, Agbaria N, Deckert A, Dambach P, Winkler V, Drexler JF, et al. Congenital abnormalities associated with Zika virus infection–Dengue as potential co-factor? A systematic review. PLoS Negl Trop Dis 2021;15:e0008984. https://doi.org/10.1371/journal.pntd.0008984
Pedrosa CSG, Souza LRQ, Gomes TA, Lima CVF, Ledur PF, Karmirian K, et al. The cyanobacterial saxitoxin exacerbates neural cell death and brain malformations induced by Zika virus. PLoS Negl Trop Dis 2020;14:e0008060. https://doi.org/10.1371/journal.pntd.0008060
De Góes Cavalcanti LP, Tauil PL, Alencar CH, Oliveira W, Teixeira MM, Heukelbach J. Zika virus infection, associated microcephaly, and low yellow fever vaccination coverage in Brazil: is there any causal link? J Infect Dev Ctries 2016;10:563-6. https://doi.org/10.3855/jidc.8575
de Araújo TVB, Ximenes RAA, Miranda-Filho DB, Souza WV, Montarroyos UR, Melo APL, et al. Association between microcephaly, Zika virus infection, and other risk factors in Brazil: final report of a case-control study. Lancet Infect Dis 2018;18:328-36. https://doi.org/10.1016/S1473-3099(17)30727-2
Gomes JA, Sgarioni E, Boquett JA, Terças-Trettel ACP, Silva JH, Ribeiro BFR, et al. Association between Genetic Variants in NOS2 and TNF Genes with Congenital Zika Syndrome and Severe Microcephaly. Viruses 2021;13:325. https://doi.org/10.3390/v13020325
Santos CNO, Ribeiro DR, Cardoso Alves J, Cazzaniga RA, Magalhães LS, Souza MSF, et al. Association Between Zika Virus Microcephaly in Newborns With the rs3775291 Variant in Toll-Like Receptor 3 and rs1799964 Variant at Tumor Necrosis Factor-α Gene. J Infect Dis 2019;220:1797-801. https://doi.org/10.1093/infdis/jiz392
Simanjuntak Y, Ko H-Y, Lee Y-L, Yu G-Y, Lin Y-L. Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice. PLOS Pathog 2020;16:e1008521. https://doi.org/10.1371/journal.ppat.1008521
Yadav S, Rawal G, Baxi M. Zika virus: A pandemic in progress. J Transl Intern Med 2016;4:42-5. https://doi.org/10.1515/jtim-2016-0009
Kleber de Oliveira W, Cortez-Escalante J, Oliveira WTGH, Carmo GMI, Henriques CMP, Coelho GE, et al. Increase in Reported Prevalence of Microcephaly in Infants Born to Women Living in Areas with Confirmed Zika Virus Transmission During the First Trimester of Pregnancy - Brazil, 2015. MMWR 2016;65:242-7. https://doi.org/10.15585/mmwr.mm6509e2
Linden V van der, Linden Junior H van der, Leal MC, Rolim Filho EL, Linden A van der, Aragão MFVV, et al. Discordant clinical outcomes of congenital Zika virus infection in twin pregnancies. Arq Neuropsiquiatr 2017;75:381-6. https://doi.org/10.1590/0004-282X20170066
Joob B, Wiwanitkit V. Congenital Zika virus infection in twin pregnancies. Arq Neuropsiquiatr 2017;75:762. https://doi.org/10.1590/0004-282X2017011
Cardoso AS, Marwell DTB, Sobral MCM, Melo GL, Casé MCC. Análise da presença do fitoplâncton em bacia integrante do Projeto de Integração do Rio São Francisco, região semiárida, Nordeste brasileiro. Eng Sanit e Ambient 2016;22:261-9. https://doi.org/10.1590/S1413-41522016146707
Sato S, Kodama M, Ogata T, Saitanu K, Furuya M, Hirayama K, et al. Saxitoxin as a toxic principle of a freshwater puffer, Tetraodon fangi, in Thailand. Toxicon 1997;35:137-40. https://doi.org/10.1016/S0041-0101(96)00003-7
Viana-Veronezi M, Giani A, Melo CS, Gome LL, Libânio M. Avaliação da remoção de saxitoxinas por meio de técnicas de tratamento das águas de abastecimento. Eng Sanit Amb 2009;14:193-204. https://doi.org/10.1590/S1413-41522009000200007
Sihuincha M, Zamora-Perea E, Orellana-Rios W, Stancil JD, López-Sifuentes V, Vidal-Oré C, et al. Potential Use of Pyriproxyfen for Control of Aedes aegypti (Diptera: Culicidae) in Iquitos, Perú. J Med Entomol 2005;42:620-30. https://doi.org/10.1093/jmedent/42.4.620
Albuquerque MFPM, Souza WV, Mendes ACG, Lyra TM, Ximenes RA, Araújo TV, et al. Pyriproxyfen and the microcephaly epidemic in Brazil - an ecological approach to explore the hypothesis of their association. Mem Inst Oswaldo Cruz 2016;111:774-6. https://doi.org/10.1590/0074-02760160291
Vani JM, Carvalho Schweich-Adami L, Auharek SA, Antoniolli-Silva ACMB, Oliveira RJ. Pyriproxyfen does not cause microcephaly or malformations in a preclinical mammalian model. Environ Sci Pollut Res 2021;28:4585-93. https://doi.org/10.1007/s11356-020-10517-5
Tirado SMC, Yoon K-J. Antibody-Dependent Enhancement of Virus Infection and Disease. Viral Immunol 2003;16:69-86. https://doi.org/10.1515/jbcpp-2021-0264
Metz SW, Thomas A, White L, Stoops M, Corten M, Hannemann H, et al. Dengue virus-like particles mimic the antigenic properties of the infectious dengue virus envelope. Virol J 2018;15:60. https://doi.org/articles/10.1186/s12985-018-0970-2
Oliver SL, Ribeiro H. Zika virus syndrome, lack of environmental policies and risks of worsening by cyanobacteria proliferation in a climate change scenario. Rev Saude Publica 2020;54:83. https://doi.org/10.11606/s1518-8787.2020054002159
Ministério da Saúde (BR). Saiba quais vacinas devem ser administradas durante a gestação. 2022. https://www.gov.br/pt-br/noticias/saude-e-vigilancia-sanitaria/2022/11/saiba-quais-vacinas-devem-ser-administradas-durante-a-gestacao
DeSilva M, Vazquez-Benitez G, Nordin JD, Lipkind HS, Romitti PA, DeStefano F, et al. Tdap Vaccination During Pregnancy and Microcephaly and Other Structural Birth Defects in Offspring. JAMA 2016;316:1823. http://doi.org/10.1001/jama.2016.14432
Amaral MS, Goulart E, Caires-Júnior LC, Morales-Vicente DA, Soares-Schanoski A, Gomes RP, et al. Differential gene expression elicited by ZIKV infection in trophoblasts from congenital Zika syndrome discordant twins. PLoS Negl Trop Dis 2020;14:e0008424. https://doi.org/10.1371/journal.pntd.0008424
Oliveira DMS, Miranda-Filho DB, Ximenes RAA, Montarroyos UR, Martelli CMT, Brickley EB, et al. Comparison of Oropharyngeal Dysphagia in Brazilian Children with Prenatal Exposure to Zika Virus, With and Without Microcephaly. Dysphagia 2021;36:583-94. https://doi.org/10.1007/s00455-020-10173-4
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Copyright (c) 2024 Letícia de Oliveira Cardoso Freitas, Talita Russo Mini, Shannon de Oliveira Hunt, Gabriel Galeazzi Corradi, Yago Guedes Rodrigues, Bruno Teixeira Marcos Moraes, Isadora Luísa Borges Bringel, Gabriela Neves Vital Santoro Autran, Hugo Martins Araujo, Rafaela da Rosa-Ribeiro
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Accepted 2024-07-30
Published 2024-08-19
