Poluição atmosférica e seu impacto atual na doença de Parkinson: uma revisão sistemática

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DOI:

https://doi.org/10.34024/rnc.2024.v32.15888

Palavras-chave:

Doença de Parkinson, poluição do ar, dióxido de nitrogênio, partículas, ozônio, monóxido de carbono

Resumo

Introdução. A doença de Parkinson (DP) é uma doença neurodegenerativa altamente prevalente que afeta milhões de pessoas em todo o mundo, caracterizada pela depleção de neurônios dopaminérgicos na substância negra. A fumaça transportada pelo ar é uma preocupação crescente e tem sido associada a processos inflamatórios agudos no corpo e a potenciais efeitos neurodegenerativos devido ao seu transporte para o cérebro através do bulbo olfatório. Objetivo. Esta revisão sistemática tem como objetivo avaliar o impacto da poluição atmosférica na DP. Método. A revisão seguiu as diretrizes Reporting Preferred Items for Systematic Reviews and Meta-Analyses (PRISMA) e foi registrada no Prospective International Register of Systematic Reviews. A busca eletrônica da literatura foi realizada nas seguintes bases de dados: PubMed, LILACS e BINACIS. Resultados. O processo de revisão identificou 2.703 artigos, dos quais 7 estudos atenderam aos critérios de inclusão e foram incluídos na revisão. Os estudos investigaram a relação entre DP e exposição a diversos poluentes atmosféricos, como PM2,5, NO2, CO. Estudos individuais forneceram resultados mistos, alguns não encontraram associações estatisticamente significativas, enquanto outros mostraram uma associação positiva entre a exposição à poluição atmosférica e a incidência de DP. Estudos que utilizam PM2,5 como indicador de poluição atmosférica demonstraram consistentemente uma possível ligação com a incidência de DP. A exposição ao PM10 e ao NO2 também mostrou alguma evidência de associação com o risco de DP. Conclusão. Esta revisão sistemática sugere que pode haver uma associação entre a poluição do ar, especialmente a exposição ao PM2,5, e a incidência da DP.

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Publicado

2024-05-14

Como Citar

Rocha Nunes, A., Carvalho, L. B., da Silva, R. A., & Silva Rovai, E. (2024). Poluição atmosférica e seu impacto atual na doença de Parkinson: uma revisão sistemática. Revista Neurociências, 32, 1–19. https://doi.org/10.34024/rnc.2024.v32.15888

Edição

Seção

Revisão Sistemática
Recebido: 2023-11-09
Aceito: 2024-04-30
Publicado: 2024-05-14

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