Analysis of hospitalizations for Guillain-Barré Syndrome from 2012 to 2023

Authors

DOI:

https://doi.org/10.34024/rnc.2023.v31.15593

Keywords:

Guillain-Barré Syndrome, COVID-19, Hospitalizations, Pandemic

Abstract

Introduction. Guillain-Barré Syndrome (GBS) is a peripheral polyneuropathy, which is classified as a rare but potentially serious neuromuscular disease that affects the peripheral nerves and the individual's immune system. Characterized by an autoimmune response, GBS results in progressive damage to myelin, the substance that protects nerve fibers. Objective. To conduct an analysis of the influence of the COVID-19 pandemic on the number of cases of GBS. Method. A cross-sectional study was conducted on GBS hospitalizations in the state of Mato Grosso from 2012 to 2023. Data were obtained from the database of the State Department of Health of Mato Grosso, treated, and dichotomized using Microsoft Excel. Results. A total of 443 GBS cases were recorded during the analyzed period. The standout years were 2018 and 2022, with 64 and 51 registered cases, respectively. In 2018, it was observed that out of the 64 hospitalized patients, only 16 required ICU admission. Furthermore, it was noticed that during the COVID-19 pandemic (2020-2022), there was an increase of 12 cases in the general population compared to the pre-pandemic period (2017-2019). Conclusion: COVID-19 acts as a triggering factor for GBS, enabling the increase in the number of cases during the pandemic period.

Keywords: Guillain-Barré Syndrome; COVID-19; Hospitalizations; Pandemic.

Metrics

Metrics Loading ...

References

VandenBerg B, Walgaard C, Drenthen J, Fokke C, Jacobs BC, Van Doorn PA. Guillain-Barre syndrome: pathogenesis, diagnosis, treatment and prognosis. Nat Rev Neurol 2014;10:469-82. https://doi.org/10.1038/nrneurol.2014.121

Willison HJ, Jacobs BC, Van Doorn PA. Guillain-Barré syndrome. Lancet 2016;388:717-27. https://doi.org/10.1016/S0140-6736(16)00339-1

Nóbrega MEB, Araújo ELL, Wada MY, Leite PL, Dimech GS, Pércio J. Surto de síndrome de Guillain-Barré possivelmente relacionado à infecção prévia pelo vírus Zika, Região Metropolitana do Recife, Pernambuco, Brasil, 2015. Epidemio Serv Saúde 2018;27:e2017039. https://doi.org/10.5123/S1679-49742018000200016

Assini A, Benedetti L, Di Maio S, Schirinzi E, Del Sette M. New clinical manifestation of COVID-19 related Guillain-Barrè syndrome highly responsive to intravenous immunoglobulins: two Italian cases. Neurol Sci 2020;41:1657-8. https://doi.org/10.1007/s10072-020-04484-5

Afonso TO, Araújo GB, Victor J, Mota F, Izabel A, Vieira A, et al. Síndrome de Guillain-Barré na Síndrome pós-COVID-19: Revisão de literatura. Res Soc Develop 2021;10:e18910716480. http://dx.doi.org/10.33448/rsd-v10i7.16480

Trujillo GLM, Valenzuela FSN, Von Oetinger GA. Relation between COVID-19 and Guillain-Barré syndrome in adults. System Rev Neurol 2020;35:646-54. https://doi.org/10.1016/j.nrl.2020.07.004

Malek E, Salameh J. Guillain-Barre Syndrome. Semin Neurol 2019;39:589-95. https://doi.org/10.1055/s-0039-1693005

Leonhand SE, Mandarakas MR, Gondim FA, Bateman K, Ferreira ML, Cornblath DR, et al. Diretrizes Baseadas em Evidências Diagnóstico e manejo da Síndrome de Guillain–Barré em dez etapas. Rev Neurocienc 2021;29:1-52. https://doi.org/10.34024/rnc.2021.v29.11725

Keyhanian K, Umeton RP, Mohit B, Davoudi V, Hajighasemi F, Ghasemi M. SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation. J Neuroimmunol 2021;350:577436. https://doi.org/10.1016/j.jneuroim.2020.577436

Salle V. Coronavirus-induced autoimmunity. Clin Immunol 2021;226:108694. https://doi.org/10.1016/j.clim.2021.108694

Sedaghat Z, Karimi N. Síndrome de Guillain Barre associada à infecção por COVID-19: relato de caso. J Clin Neurosci 2020;76:233. https://doi.org/10.1016/j.jocn.2020.04.062

Payus AO, Lin CLS, Noh MM, Jeffree MS, Ali RA. SARS-CoV-2 infection of the nervous system: A review of the literature on neurological involvement in novel coronavirus disease-(COVID-19). Bosn J Basic Med Sci 2020;20:283-92. https://doi.org/10.17305/bjbms.2020.4860

Zito A, Alfonsi E, Franciotta D, Todisco M, Gastaldi M, Cotta Ramusino M, et al. COVID-19 and Guillain-Barré Syndrome: A Case Report and Review of Literature. Front Neurol 2020;11:909. https://doi.org/10.3389/fneur.2020.00909

Rigo DFH, Ross C, Hofstatter LM, Ferreira MFAPL. Síndrome de Guillain Barré: perfil clínico epidemiológico y asistencia de enfermería. Enferm Global 2019;19:346-89. https://doi.org/10.6018/eglobal.19.1.366661

Uncini A, Notturno F, Kuwabara S. Hyper-reflexia in Guillain-Barré syndrome: systematic review. J Neurol Neurosurg Psychiatry 2020;91:278-84. https://doi.org/10.1136/jnnp-2019-321890

Malta JMAS, Ramalho WM. Aumento das internações por síndrome de Guillain-Barré no Brasil: estudo ecológico. Epidemiol Serv Saúde 2020;4:e2020056. http://dx.doi.org/10.5123/s1679-49742020000400020

Paraná. Protocolo de vigilância da síndrome de guillain-barré e outras doenças neurológicas agudas graves pós-infecciosas. Secretaria De Estado da Saúde Superintendência de Vigilância em Saúde, versão 4.0, 2016.

https://lacen.saude.pr.gov.br/sites/lacen/arquivos_restritos/files/documento/2020-08/sesapr_protoc_vigilsgb_16_09_2016.pdf

Papri N, Hayat S, Mohammed A, Afsar MNA, Hasan I, Rahman A, et al. Guillain-Barré syndrome associated with SARS-CoV-2 infection: A case report with long term follow up. J Neuroimmunol 2021;356:577590. https://doi.org/10.1016/j.jneuroim.2021.577590

Dufour C, Co TK, Liu A. GM1 ganglioside antibody and COVID-19 related Guillain Barre Syndrome - A case report, systemic review and implication for vaccine development. Brain Behav Immun Health 2021;12:100203. https://doi.org/10.1016/j.bbih.2021.100203

Published

2023-12-05

Issue

Section

Artigos Originais

How to Cite

1.
Maccari Soares AC, Mesanini de Souza AI, , Castro Lima Lucena N. Analysis of hospitalizations for Guillain-Barré Syndrome from 2012 to 2023. Rev Neurocienc [Internet]. 2023 Dec. 5 [cited 2025 Dec. 13];31:1-15. Available from: https://periodicos.unifesp.br/index.php/neurociencias/article/view/15593
Received 2023-09-01
Accepted 2023-11-30
Published 2023-12-05