Suplementação de fontes de oleuropeína em doenças neurodegenerativas: revisão sistemática
DOI:
https://doi.org/10.34024/rnc.2023.v31.15400Palavras-chave:
Azeite de oliva, oleuropeína, oliveira, suplementos nutricionais, humanosResumo
Introdução. Os frutos e folhas extraídos das Oliveiras, como o azeite de oliva extra virgem (AOEV) e seu polifenol mais abundante, a Oleuropeína (OLE), apresentam diversos benefícios terapêuticos, incluindo atividade neuroprotetora. A população idosa enfrenta a ameaça de problemas de saúde relacionados à neurodegeneração. Biomarcadores de alterações cerebrais de Alzheimer, além de sintomas como declínio cognitivo de algumas funções, perda de memória ou velocidade de processamento são sintomas que podem indicar o desenvolvimento de doenças neurodegenerativas exigindo que rotas de tratamento eficazes sejam procuradas. Objetivo. O objetivo desta revisão foi avaliar os efeitos da suplementação de azeite de oliva e outras fontes de oleuropeína em indivíduos com doenças neurodegenerativas. Método. Por meio dos bancos de dados PubMed, Scopus e Web of Science, estudos clínicos que examinam a relação entre AOEV, Oleuropeína e doenças neurodegenerativas até janeiro de 2023 foram sistematicamente pesquisados. A análise de evidências foi realizada usando ferramentas robustas para avaliar o risco de viés (RoB 2.0) e qualidade metodológica (GRADE) dos estudos incluídos. Resultados. Um total de quatro estudos foram incluídos. As condições neurológicas incluem Doença de Alzheimer e Comprometimento Cognitivo Leve. Conclusão. No geral, benefícios terapêuticos neuroprotetores foram observados através da suplementação de AOEV e OLE. Os estudos atualmente publicados, no entanto, são limitados, exigindo continuidade e aperfeiçoamento da metodologia de intervenção empregada.
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Copyright (c) 2023 Giovana Pinheiro Faleiro, Matheus Büttner Borges, Isabele Rejane de Oliveira Maranhão Pureza, Simone Morelo Dal Bosco
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Aceito: 2023-09-21
Publicado: 2023-10-23
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