Doenças neurodegenerativas e canabinoides: revisão narrativa
DOI:
https://doi.org/10.34024/rnc.2023.v31.14952Palavras-chave:
Doenças neurodegenerativas, Neuroinflamação, Canabidinoides, CanabidiolResumo
Introdução. As doenças neurodegenerativas afetam grande parte da população no mundo, principalmente idosos. Essas patologias interrompem a função motora e cognitiva, a homeostase dos pacientes, impactando na qualidade de vida. As terapias atuais para os distúrbios neurodegenerativos têm a finalidade de aliviar os sintomas e à medida que a doença progride, a eficácia dos tratamentos farmacológicos é reduzida. Objetivo. Descrever sobre as principais doenças neurodegenerativas e a utilização do canabinoides como alternativa no tratamento destas patologias. Método. Estudo de revisão narrativa que mostra as principais doenças neurodegenerativas e a utilização dos canabinoides para o tratamento de doenças neurodegenerativas. Resultados. Os estudos mostraram que os derivados da Cannabis sativa apresentam potencial terapêutico para o tratamento das doenças neurodegenerativas devido as suas propriedade anti-inflamatórias, antioxidantes e neuroprotetoras. Os principais compostos, o canabidiol (CBD) e Tetrahidrocanabinol (THC) apresentam importante papel na neuromodulação no sistema nervoso central degenerado, minimizando os danos causados pelas doenças neurodegenerativas. Conclusões. Apesar da literatura apontar o potencial terapêutico dos canabinoides, ainda há incertezas sobre a qualidade dos produtos e as doses consideradas ativas, bem como de interações medicamentosas.
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Copyright (c) 2023 Cyntia Michielin Lopes, Rick Wilhiam de Camargo, Rafael Mariano Bitencourt
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Aceito: 2023-09-21
Publicado: 2023-10-23
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