Correlações entre estereotipias no TEA e neurotransmissores: revisão sistemática
DOI:
https://doi.org/10.34024/rnc.2023.v31.14121Palavras-chave:
Comportamento Estereotipado, Transtorno do Espectro Autista, Neurotransmissores, Modelos AnimaisResumo
Introdução. Há evidências que neurotransmissores e seus sistemas podem estar envolvidos na fisiopatologia de estereotipias motoras no Transtorno do Espectro Autista. Objetivo. Conduzir uma revisão para avaliar evidências sobre correlações entre comportamentos estereotipados e alterações nos sistemas de neurotransmissores, pela análise de artigos originais em modelo animal. Método. Estudos publicados entre janeiro de 2000 e janeiro de 2021 foram pesquisados em seis bases de dados e 19 estudos foram selecionados. A população, o método, os principais resultados e as conclusões dos artigos foram extraídos. Resultados. A análise revelou que os sistemas serotoninérgico, dopaminérgico, glutamatérgico, colinérgico e GABAérgico estavam envolvidos na modulação de estereotipias nos modelos animais do TEA. Em geral, a administração de antagonistas de receptors serotoninérgicos, glutamatérgicos e dopaminérgicos causaram uma redução no comportamento estereotipado, e a estimulação dos sistemas GABAérgico e colinérgico, através da administração de agonistas de receptors, também foram responsáveis por reduzir esses comportamentos. Houve algumas discrepâncias nas respostas dependendo das rotas de administração da droga e das áreas cerebrais, sugerindo que esses fatores também influenciam na fisiopatologia das estereotipias no TEA. Conclusão. Os estudos sugerem que a super-ativação dos sistemas serotoninérgico, glutamatérgico e dopaminérgico, assim como a supressão dos sistemas GABAérgico e colinérgico podem ter uma influência direta no aparecimento e na modulação de estereotipias. Registro: PROSPERO CRD42021235397
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Copyright (c) 2023 Fernanda Ingrid Oliveira Ramos, Karen Gibson Terra Ferreira Martins; Tatiana Paschoallete Rodrigues Bachur; Gislei Aragao
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Aceito: 2023-02-06
Publicado: 2023-02-27
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