Cognitive impairment following COVID-19: a systematic review
DOI:
https://doi.org/10.34024/rnc.2022.v30.13848Keywords:
Cognitive Dysfunction, Cognition, COVID-19, SARS-CoV-2Abstract
Introduction. COVID-19 has demonstrated high potential for mortality and multisystemic inflammation and by affecting the nervous system it may lead to cognitive deficits at all stages of the disease as well as after recovery. Objective. Assess cognitive changes in individuals diagnosed with COVID-19. Method. The search for scientific articles occurred in electronic databases MEDLINE (Pubmed), LILACS, SciELO, SCOPUS, WEB OF SCIENCE and BIREME, without locational restrictions, during the period of 2020 to 2022. Selection criteria included studies on the COVID-19 relationship and cognitive changes in adults and elderly people from 18 years and over, published within the last two years, and excluded letters to the editor, guidelines, literature reviews, narrative reviews, systematic reviews, meta-analyses, abstracts, case reports, and case series. Results. 11 studies were included, seven of the cross-sectional type and four of the case-control type. Five studies were conducted in hospitalized patients and six in patients not hospitalized and/or recovered from the disease. Ten pointed to a positive association between COVID-19 and cognitive deficits and one showed no association. Conclusion. COVID-19 is significantly associated with cognitive deficits in the acute phase or after recovery, regardless of severity and hospitalization status. The main altered cognitive functions observed were alteration of attention, memory, language, executive functions, and processing speed.
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References
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Copyright (c) 2022 Vitor Martins Guesser, Karina Mary Paiva, Vitória Neves de Barros, Laura Faustino Gonçalves, Patricia Haas
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Accepted 2022-08-31
Published 2022-10-04
