Sudden Unexpected Death in Parkinson's Disease: What is the involvement of the heart?
DOI:
https://doi.org/10.34024/rnc.2021.v29.12642Keywords:
Parkinson's disease, sudden death, SUDPAR, cardiac abnormalities, autonomic dysfunctionsAbstract
Introduction. Parkinson's disease (PD) is the second most common neurodegenerative disease. It is a progressive neurological disorder, reaching more than 1% of the population over 60 years, mostly men. The mortality rate of patients with PD is higher when compared to the general population. The causes of this high mortality are unknown, but cardiovascular risk factors can play an important role. Thus, sudden unexpected death in Parkinson's disease (SUDPAR), corresponds to an important event that, although rare, also occurs. Objective. The purpose of this review is to present the main findings in the literature regarding the relationship between cardiovascular and autonomic dysfunctions with sudden death in PD. Method. The research was carried out in the Scielo, Google scholar and PubMed databases for the term Parkinson's disease in combination with the terms (i) sudden death, (ii) sudden unexpected death, (iii) SUDPAR, (iv) cardiac abnormalities and (v) autonomic disfunctions. All relevant publications were considered. Results. There are still few studies in the literature on SUDPAR, and from 2006 to 2020, 22 papers were published, including letters to the editor, reviews and case reports. Clinical and experimental research suggests that cardiac abnormalities and autonomic dysfunctions play a key role. Conclusion. Several studies have shown cardiac involvement in PD, and autonomic dysfunctions are frequent causes of death in patients with this disease. The collaboration between doctors and researchers is essential to identify approaches that, considering cardiological research, offer the possibility of preventing SUDPAR.
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References
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