Consumo de cafeína e doença de Parkinson: uma mini-revisão das evidências recentes

Autores

DOI:

https://doi.org/10.34024/rnc.2021.v29.12641

Palavras-chave:

cafeína, Doença de Parkinson, distúrbios neurodegenerativos

Resumo

Na ausência de tratamentos eficientes para a doença de Parkinson (DP), a pesquisa se concentrou na identificação de fatores ambientais potenciais, cuja modulação pode prevenir ou retardar a progressão deste distúrbio neurodegenerativo. Evidências epidemiológicas convincentes sugerem que o consumo de cafeína está inversamente associado ao risco de desenvolver DP. Outros achados experimentais demonstraram que a cafeína, ao direcionar particularmente os receptores de adenosina A2A (A2AR), protegeu os modelos animais de DP contra a perda de neurônios dopaminérgicos. A ação antagônica da cafeína nos receptores de adenosina não apenas desacelerou a neurodegeneração relacionada à DP, mas também melhorou os sintomas motores e não motores da DP em modelos animais. Aqui, revisamos os mecanismos de ação potenciais pelos quais a cafeína pode desempenhar um papel na redução do risco de DP. Também revisamos as evidências atuais dos benefícios do consumo de cafeína nos sintomas motores e não motores da DP. Finalmente, apontamos como esses achados promissores podem levar à identificação de novas abordagens para o tratamento eficaz da DP.

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Publicado

2021-08-20

Como Citar

Victorino, D. B., Guimarães-Marques, M. J., & Nehlig, A. (2021). Consumo de cafeína e doença de Parkinson: uma mini-revisão das evidências recentes. Revista Neurociências, 29. https://doi.org/10.34024/rnc.2021.v29.12641

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Artigos de Revisão
Recebido em 2021-08-20
Publicado em 2021-08-20