Estratégias farmacológicas de drogas na Doença de Alzheimer
DOI:
https://doi.org/10.34024/rnc.2021.v29.12413Palavras-chave:
Doença de Alzheimer, desenvolvimento de drogas, ensaios clínicos, inibidores ROCKResumo
Introdução. A doença de Alzheimer (DA) é uma doença neurodegenerativa de mau prognóstico e sem cura que afeta milhões de pessoas em todo o mundo. Os medicamentos atualmente em estudos clínicos tentam investigar possíveis efeitos terapêuticos que progridem ou interrompem a doença. Objetivo. Esta revisão é necessária para criar um panorama atual em 2021, descrevendo as principais vias em estudo para inibir importantes vias de progressão da doença, como vias do sistema colinérgico e inibidores de ROCK, bem como novas perspectivas de tratamento com possível combinação de drogas, para diminuir neuroinflamação e alterar o curso da doença. Método. Avaliado ClinicalTrials.gov em 19 de janeiro de 2021, identificou todos os ensaios de agentes farmacológicos em desenvolvimento para o tratamento da DA na fase 3 do estudo clínico, obtendo assim um panorama global para conter essa doença devastadora, criando melhores perspectivas sobre o tratamento da DA. Resultados. Diferentes medicamentos (n=25) foram divididos por tipos de alvos de vias neurofisiológicas (inibidor de amiloide; inibidor de tau; receptores de neurotransmissores; anti-inflamatórios não esteroides (AINEs), mitocôndrias e funções metabólicas; plasticidade sináptica). Conclusões. Os avanços nos ensaios clínicos trazem esperança e novos caminhos, pois os alvos para o tratamento da DA são encorajados e prometem novas linhas de tratamento. Novos estudos com mais combinações terapêuticas que alterem o curso da doença devem ser incentivados.
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Copyright (c) 2021 Rodrigo Lantyer Marques Dantas, Nathalia Clemente Baracho, Antoni Camins, Miren Ettcheto
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Publicado: 2021-07-12
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