Evidências para paralisia do nervo facial e SARS-CoV-2

Autores

DOI:

https://doi.org/10.34024/rnc.2021.v29.12013

Palavras-chave:

COVID-19, paralisia facial, nervos, SARS-CoV-2

Resumo

Introdução. A Organização Mundial da Saúde (OMS) reconheceu uma nova cepa de coronavírus, a Síndrome Respiratória Aguda Grave Coronavírus 2 (SARS-CoV-2), chamada Doença Coronavírus 2019 (COVID-19). Os sintomas mais leves e comuns incluem febre, fadiga e tosse; no entanto, casos mais graves da doença podem causar dificuldades respiratórias, insuficiência renal e cardíaca e, eventualmente, morte. No entanto, um número crescente de relatos de manifestações neurológicas tem surgido. Objetivo. Proporcionar uma revisão abrangente das manifestações neurológicas da SARS‐CoV‐2 e principalmente a relação entre a paralisia aguda do nervo facial e a COVID-19 bem como seus resultados na mortalidade e as implicações que isso tem na prática clínica. Método. A pesquisa em sete bancos de dados (PubMed, Cochrane Library, Lilacs, Scielo, Web of Science, Scopus e Google Scholar) foi realizada por dois revisores independentes na busca por evidências da paralisia do Nervo Facial (VII) e SARS-CoV-2. Após a triagem os dados foram coletados e discutidos. Resultados. A paralisia facial idiopática é chamada de paralisia de Bell e estudos mostraram que a paralisia facial aumentou durante o período de pandemia de COVID-19. Existem muitos relatos sobre a relação entre COVID-19 e paralisia facial, porém pouca evidência real de sua relação. Conclusão. Ainda é questionável se esses distúrbios neuroimunológicos ocorrem diretamente da infecção viral ou como sequelas autoimunes. A patogênese da doença por trás dessa manifestação ainda não é totalmente compreendida. Acreditamos que mais pesquisas devam ser realizadas para esclarecer a associação levantada por este estudo.

 

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Referências

Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID‐19) outbreak. J Autoimmun 2020;109:102433. https://doi.org/10.1016/j.jaut.2020.102433

Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 2020;77:683.

https://doi.org/10.1001/jamaneurol.2020.1127

McCray PB, Pewe L, Wohlford-Lenane C, Hickey M, Manzel L, Shi L, et al. Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol 2007;81:813–21. https://doi.org/10.1128/JVI.02012-06

Li K, Wohlford-Lenane C, Perlman S, Zhao J, Jewell AK, Reznikov LR, et al. Middle east respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4. J Infect Dis 2016;212:712–22. https://doi.org/10.1093/infdis/jiv499

Netland J, Meyerholz DK, Moore S, Cassell M, Perlman S. Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2. J Virol 2008;82:7264–75. https://doi.org/10.1128/JVI.00737-08

Baig A, Khaleeq A, Ali U, Syeda H. Evidence of the COVID‐19 virus targeting the CNS: tissue distribution, host‐virus interaction, and proposed neurotropic mechanisms. ACS Chem Neurosci 2020;11:995‐8. https://dx.doi.org/10.1021/acschemneuro.0c00122

Wrapp D, Wang N, Corbett K, Goldsmith JA, Hsieh C-L, Abiona O, et al. Cryo‐EM structure of the 2019‐nCoV spike in the prefusion conformation. Science 2020;367:1260-3. https://doi.org/10.1126/science.abb2507

Peitersen E. Bell’s palsy: the spontaneous course of 2,500 peripheral facial nerve palsies of different etiologies Acta Otolaryngol Suppl 2002;122:4-30. https://doi.org/10.1080/000164802760370736

McGovern FH, Estevez J, Jackson R. Immunological concept for Bell’s palsy: further experimental study. Ann Otol Rhinol Laryngol 1977;86:300-5. https://doi.org/10.1177%2F000348947708600304

McCormick DP. Herpes-simplex virus as a cause of Bell’s palsy. Lancet 1972;1:937-9. https://doi.org/10.1016/S0140-6736(72)91499-7

Kum RO, Yurtsever Kum N, Ozcan M, Yilmaz YF, Gungor V, Unal A, et al. Elevated neutrophil-to-lymphocyte ratio in Bell’s palsy and its correlation with facial nerve enhancement on MRI. Otolaryngol Head Neck Surg 2015;152:130-5.

https://doi.org/10.1177/0194599814555841

Guo L, Ren L, Yang S, Xiao M, Chang D, Yang F, et al. Profiling early humoral response to diagnose novel coronavirus disease (COVID-19). Clin Infect Dis 2020;71:778-85. https://doi.org/10.1093/cid/ciaa310

Zhang G, Nie S, Zhang Z, Zhang Z. Longitudinal change of SARS-Cov2 antibodies in patients with COVID-19. J Infect Dis 2020;10. https://doi.org/10.1093/infdis/jiaa229

Heckmann JG, Urban PP, Pitz S, Guntinas‐Lichius O, Gágyor I. The Diagnosis and Treatment of Idiopathic Facial Paresis (Bell’s Palsy). Dtsch Arztebl Int 2019;116:692‐702.

https://dx.doi.org/10.3238%2Farztebl.2019.0692

Sadé J. Pathology of Bell’s Palsy. Arch Otolaryngol 1972;95:406‐14. https://doi.org/10.1001/archotol.1972.00770080642003

Islamoglu Y, Celik B, Kiris M. Facial paralysis as the only symptom of COVID-19: A prospective study. Am J Otolaryngol 2021;42:102956. https://doi.org/10.1016/j.amjoto.2021.102956

May M, Klein SR. Differential diagnosis of facial nerve palsy Otolaryngol Clin North Am 1991;24:613-45.

https://doi.org/10.1016/S0030-6665(20)31118-X

Casas E, Barbosa A, Rubio-García E, Cebrián J, Díaz-Pérez C, de la Fuente E, et al. Parálisis facial periférica aislada en un paciente con COVID-19 [Isolated peripheral facial paralysis in a patient with COVID-19]. Rev Neurol 2020;71:40-1.

https://doi.org/10.33588/rn.7101.2020229

Goh Y, Beh DLL, Makmur A, Somani J, Chan ACY. Pearls & oysters: facial nerve palsy in COVID-19 infection. Neurology 2020;95:364-7.

https://doi.org/10.1212/WNL.0000000000009863

Ribeiro BNF, Marchiori E. Facial palsy as a neurological complication of SARS-CoV-2. Arq Neuropsiquiatr 2020;78:667.

https://doi.org/10.1590/0004-282X20200127

Codeluppi L, Venturelli F, Rossi J, Fasano A, Toschi G, Pacillo F, et al. Facial palsy during the COVID-19 pandemic. Brain Behav 2020;e01939. https://doi.org/10.1002/brb3.1939

Zammit M, Markey A, Webb C. A rise in facial nerve palsies during the coronavirus disease 2019 pandemic. J Laryngol Otol 2020;1-4. https://doi.org/10.1017/S0022215120002121

Brisca G, Garbarino F, Carta S, Palmieri A, Vandone M, Severino M, et al. Increased childhood peripheral facial palsy in the emergency department during COVID-19 pandemic. Pediatr Emerg Care 2020;36:e595-6. https://doi.org/10.1097/PEC.0000000000002231

Montenegro P, Brotons C, Serrano J, Fernández D, Garcia-Ramos C, Ichazo B, et al. Community seroprevalence of COVID-19 in probable and possible cases at primary health care centres in Spain. Fam Pract 2020;cmaa096. https://doi.org/10.1093/fampra/cmaa096

Pan Y, Li X, Yang G, Fan J, Tang Y, Hong X, et al. Seroprevalence of SARS-CoV-2 immunoglobulin antibodies in Wuhan, China: part of the city-wide massive testing campaign. Clin Microbiol Infect 2020;33035672. https://doi.org/10.1016/j.cmi.2020.09.044

Borges LP, Martins AF, de Melo MS, de Oliveira MGB, Neto JMR, Dósea MB, et al. Seroprevalence of SARS-CoV-2 IgM and IgG antibodies in an asymptomatic population in Sergipe, Brazil. Rev Panam Salud Publica 2020;44.

https://doi.org/10.26633/RPSP.2020.108

Lascano AM, Epiney J‐B, Coen M, Serratrice J, Bernard-Valnet R, Lalive PH, et al. SARS‐CoV‐2 and Guillain–Barré syndrome: AIDP variant with favorable outcome. Eur J Neurol 2020;27:1751-3. https://doi.org/10.1111/ene.14368

Gutiérrez‐Ortiz C, Méndez A, Rodrigo‐Rey S, San Pedro-Murillo E, Bermejo-Guerrero L, Gordo-Mañas R, et al. Miller Fisher syndrome and polyneuritis cranialis in COVID‐19. Neurology 2020;95:e601-5. https://doi.org/10.1212/WNL.0000000000009619

Caamaño DSJ, Beato RA. Facial diplegia, a possible atypical variant of Guillain–Barré syndrome as a rare neurological complication of SARS‐CoV‐2. J Clin Neurosci 2020;77:230-2.

https://doi.org/10.1016/j.jocn.2020.05.016

Defreitasferreira ACA, Romão TT, Silvamacedo Y, Pupe C, Nascimento OJ. COVID‐19 and herpes zoster co‐infection presenting with trigeminal neuropathy. Eur J Neurol 2020;27:1748-50. https://doi.org/10.1111/ene.14361

Toscano G, Palmerini F, Ravaglia S, Ruiz L, Invernizzi P, Cuzzoni MG, et al. Guillain-Barré syndrome associated with SARS-CoV-2. N Engl J Med Epub 2020;382:2574-6.

https://doi.org/10.1056/NEJMc2009191

Yue Wan, Shugang Cao, Qi Fang et al. Coronavirus disease 2019 complicated with Bell’s palsy: a case report. Version 1. Res Squ 2020;3.rs-23216/v1. https://doi.org/10.21203/rs.3.rs-23216/v1

Eviston TJ, Croxson GR, Kennedy PGE, Hadlock T, Krishnan VA. Bell's palsy: aetiology, clinical features and multidisciplinary care. J Neurol Neurosurg Psychiatry 2015;86:1356-61.

http://dx.doi.org/10.1136/jnnp-2014-309563

Romoli M, Jelcic I, Bernard‐Valnet R, García-Azorín D, Mancinelli L, Akhvlediani T, et al. A systematic review of neurological manifestations of SARS‐CoV‐2 infection: the devil is hidden in the details. Eur J Neurol 2020;27:1712-26. https://doi.org/10.1111/ene.14382

Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. J Med Virol 2020;92:552-5. https://doi.org/10.1002/jmv.25728

He X, Lau EHY, Wu P, Deng X, Wang J, Hao X, et al. Temporal dynamics in viral shedding and transmissibility of COVID-19. Nat Med 2020;26:672-5. https://doi.org/10.1038/s41591-020-0869-5

Whittaker A, Anson M, Harky A. Neurological manifestations of COVID‐19: a systematic review and current update. Acta Neurol Scand 2020;142:14-22. https://doi.org/10.1111/ane.13266

Kermali M, Khalsa RK, Pillai K, Ismail Z, Harky A. The role of biomarkers in diagnosis of COVID‐19 ‐ A systematic review. Life Sci 2020;117788. https://doi.org/10.1016/j.lfs.2020.117788

Zaim S, Chong JH, Sankaranarayanan V, Harky A. COVID‐19 and Multi‐Organ Response. Curr Probl Cardiol 2020;100618.

https://doi.org/10.1016/j.cpcardiol.2020.100618.

Khan IH, Zahra SA, Zaim S. At the heart of COVID‐19. J Card Surg 2020;35:1287-94. https://doi.org/10.1111/jocs.14596.

Harky A, Chiu CM, Yau THL, Lai SHD. Cancer Patient Care during COVID‐19. Cancer Cell 2020;37:749-50.

https://doi.org/10.1016/j.ccell.2020.05.006

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Publicado

2021-09-27

Como Citar

Gomes da Silva Teles, S., Carneiro, A. L. S., & Pestana, R. de C. S. (2021). Evidências para paralisia do nervo facial e SARS-CoV-2. Revista Neurociências, 29, 1–14. https://doi.org/10.34024/rnc.2021.v29.12013

Edição

Seção

Artigos de Revisão
Recebido em 2021-04-23
Aceito em 2021-08-23
Publicado em 2021-09-27