Efeitos do estrogênio sobre a cognição da mulher em menopausa

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DOI:

https://doi.org/10.34024/rnc.2022.v30.12006

Palavras-chave:

Estrogênio, Cognição, Menopausa, Déficit cognitivo, Hormonioterapia, Estradiol

Resumo

Introdução. O estrogênio é um hormônio que vem sendo estudado pela sua possível relação com a cognição, mais especificamente, com o declínio cognitivo nas mulheres durante o período da menopausa. Objetivo. Elucidar os avanços na efetividade do uso de hormônios estrogênios para a melhora da cognição em mulheres no período perimenopausa. Método. O presente estudo foi realizado com um apanhado de pesquisas encontradas nas plataformas PubMed e Scielo com o intuito de abranger opiniões diversas acerca do tema proposto. Resultados. No decorrer do tempo, foram identificados tanto casos nos quais o déficit da concentração de estrogênio causou alterações cognitivas, quanto casos nos quais esse dado não foi observado. Inicialmente, os estudos não demonstravam caráter positivo no uso do estrogênio em hormonioterapia, todavia, brevemente, foram levantadas as hipóteses do tratamento necessitar ser iniciado em um delimitado período após a menopausa para que obtivesse resultados positivos. Desde então, esta é uma das questões primordiais para o desenvolvimento de uma terapia segura e efetiva. Entretanto, ainda existe divergência acerca da efetividade da HT, além de até o momento inexistir um consenso acadêmico sobre o início e término desta janela terapêutica. Conclusão. Portanto, evidencia-se a necessidade de mais pesquisas sobre o tema para esclarecer a eficácia da hormonioterapia e os efeitos do estrogênio nos déficits cognitivos em mulheres pós-menopausa.

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Referências

Foster TC. Role of estrogen receptor alpha and beta expres- sion and signaling on cognitive function during aging. Hippocampus 2011;22:656-69. http://dx.doi.org/10.1002/hipo.20935

Sellers K, Raval P, Srivastava DP. Molecular signature of rapid estro- gen regulation of synaptic connectivity and cognition. Front Neuroendo- crinol 2015;36:72-89. http://dx.doi.org/10.1016/j.yfrne.2014.08.001

Luine VN. Estradiol and cognitive function: Past, present and fu- ture. Horm Behav 2014;66:602-18. http://dx.doi.org/10.1016/j.yhbeh.2014.08.011

Woolley C, McEwen B. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat [published erratum appears in J Neurosci 1992;12]. J Neurosci 1992;12:2549-54. http://dx.doi.org/10.1523/JNEUROSCI.12-07-02549.1992

Morgan KN, Derby CA, Gleason CE. Cognitive Changes with Reproductive Aging, Perimenopause, and Menopause. Obstetric Gynecol Clin North Am 2018;45:751-63. http://dx.doi.org/10.1016/j.ogc.2018.07.011

Barha CK, Galea LAM. Influence of different estrogens on neuroplasticity and cognition in the hippocampus. Biochim Biophys Acta 2010;1800:1056-67. http://dx.doi.org/10.1016/j.bbagen.2010.01.006

Scott E, Zhang Q, Wang R, Vadlamudi R, Brann D. Estrogen neuroprotection and the critical period hypothesis. Front Neuroendocrinol 2012;33:85-104. http://dx.doi.org/10.1016/j.yfrne.2011.10.001

Bezerra TA, Lima ECS, Araújo AL, Rosário KD. Terapia de reposição hormonal na menopausa. Rev Inic Cient Ext 2019;2:247-9. https://revistasfacesa.senaaires.com.br/index.php/iniciacao-cientifica/article/ view/265

Barron AM, Pike CJ. Sex hormones, aging, and Alzheimer’s disease. Front Biosci 2012;4:976. http://dx.doi.org/10.2741/E434

Henderson VW. The Neurology of Menopause. Neurologist 2006;12:149-59. http://dx.doi.org/10.1097/01.nrl.0000215750.52786.b1

Yao J, Brinton RD. Estrogen Regulation of Mitochondrial Bioenergetics. In: Current State of Alzheimer’s Disease Research and Therapeutics. Elsevier; 2012. p.327-71.

http://dx.doi.org/10.1016/B978-0-12-394816-8.00010-6

Shumaker SA, Legault C, Rapp SR, Thal L, Wallace RB, Ockene JK, et al. Estrogen Plus Progestin and the Incidence of Dementia and Mild Cognitive Impairment in Postmenopausal Women. JAMA 2003;289:2651. http://dx.doi.org/10.1001/jama.289.20.2651

Matyi JM, Rattinger GB, Schwartz S, Buhusi M, Tschanz JT. Lifetime estrogen exposure and cognition in late life. Menopause 2019;26:1366- 74. http://dx.doi.org/10.1097/GME.0000000000001405

Simpkins JW, Singh M, Brock C, Etgen AM. Neuroprotection and Estrogen Receptors. Neuroendocrinol 2012;96:119-30.

http://dx.doi. org/10.1159/000338409

Lente CL, Velasque LFL. Efeitos da terapia hormonal na menopausa: Revisão de literatura. Biosaúde 2015;17:74-81.

https://www.uel.br/revistas/uel/index.php/biosaude/article/view/26365

Araujo AR, Chagas RKF, Lima ICS. Alternative Therapies for Menopausal Symptom Care: Outlining Possibilities And Challenges. Rev Fun Care Online 2020;12:1267-73. http://dx.doi.org/10.9789/2175-5361.rpcfo.v12.7967

Sliwinski JR, Johnson AK, Elkins GR. Memory Decline in Peri- and Post-menopausal Women: The Potential of Mind–Body Medicine to Improve Cognitive Performance. Integr MedInsights 2014;9:IMI. S15682. http://dx.doi.org/10.4137/imi.s15682

Zárate S, Stevnsner T, Gredilla R. Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair. Front Aging Neurosci 2017;9:1-22. http://dx.doi.org/10.3389/fnagi.2017.00430

Morgan KN, Derby CA, Gleason CE. Cognitive Changes with Reproductive Aging, Perimenopause, and Menopause. Obstetric Gynecol Clin North Am 2018;45:751-63.

http://dx.doi.org/10.1016/j.ogc.2018.07.011

Hu J, Chu K, Song Y, Chatooah ND, Ying Q, Ma L, et al. Higher level of circulating estradiol is associated with lower frequency of cognitive impairment in Southeast China. Gynecol Endocrinol 2017;33:840-4. http://dx.doi.org/10.1080/09513590.2017.1320379

Greendale GA, Huang M-H, Wight RG, Seeman T, Luetters C, Avis NE, et al. Effects of the menopause transition and hormone use on cognitive performance in midlife women. Neurology 2009;72:1850-7. http://dx.doi.org/10.1212/wnl.0b013e3181a71193

Fuh J-L, Wang S-J, Lee S-J, Lu S-R, Juang K-D. A longitudinal study of cognition change during early menopausal transition in a rural community. Maturitas 2006;53:447-53.

http://dx.doi.org/10.1016/j.maturitas.2005.07.009

Luine VN. Estradiol and cognitive function: Past, present and future. Horm Behav 2014;66:602-18.

http://dx.doi.org/10.1016/j.yhbeh.2014.08.011

Genazzani AR, Pluchino N, Luisi S, Luisi M. Estrogen, cognition and female ageing. Hum Reproduc Update 2006;13:175-87.

http://dx.doi. org/10.1093/humupd/dml042

Nguyen PV, Connor SA. Noradrenergic Regulation of Hippocampus- Dependent Memory. CNSAMC 2019;19:187-96.

http://dx.doi.org/10.2 174/1871524919666190719163632

Opitz B. Memory Function and the Hippocampus. In: Frontiers of Neurology and Neuroscience. KARGER AG; 2014. p.51-9.

http://dx.doi. org/10.1159/000356422

Lindauer RJL, Olff M, van Meijel EPM, Carlier IVE, Gersons BPR. Cortisol, Learning, Memory, and Attention in Relation to Smaller Hippocampal Volume in Police Officers with Posttraumatic Stress Disorder. Biolog Psychiatr 2006;59:171-7.

http://dx.doi.org/10.1016/j. biopsych.2005.06.033

Holmes A, Wellman CL. Stress-induced prefrontal reorganization and executive dysfunction in rodents. Neurosci Biobehav Rev 2009;33:773- 83. http://dx.doi.org/10.1016/j.neubiorev.2008.11.005

Saldanha CJ. Estrogen as a Neuroprotectant in Both Sexes: Stories From the Bird Brain. Front Neurol 2020;11:1-8.

http://dx.doi. org/10.3389/fneur.2020.00497

Raghava N, Das BC, Ray SK. Neuroprotective effects of estrogen in CNS injuries: insights from animal models. NAN 2017;6:15-29.

http:// dx.doi.org/10.2147/NAN.S105134

Henderson VW. Action of estrogens in the aging brain: Dementia and cognitive aging. Biochim Biophys Acta 2010;1800:1077-83.

http:// dx.doi.org/10.1016/j.bbagen.2009.11.005

Zhou G, Liu J, Sun F, Duan L, Yan B, Peng Q. Cognitive Functioning in Elderly Women Who Underwent Unilateral Oophorectomy Before Menopause. Inter J Neurosci 2011;121:196-200.

http://dx.doi.org/10. 3109/00207454.2010.542842

Wallace M, Luine V, Arellanos A, Frankfurt M. Ovariectomized rats show decreased recognition memory and spine density in the hippocampus and prefrontal cortex. Brain Res 2006;1126:176-82. http://dx.doi.org/10.1016/j.brainres.2006.07.064

Tuscher JJ, Fortress AM, Kim J, Frick KM. Regulation of object recognition and object placement by ovarian sex steroid hormones. Behav Brain Res 2015;285:140-57.

http://dx.doi.org/10.1016/j. bbr.2014.08.001

Djiogue S, Djiyou Djeuda AB, Seke Etet PF, Ketcha Wanda GJM, Djikem Tadah RN, Njamen D. Memory and exploratory behavior impairment in ovariectomized Wistar rats. Behav Brain Funct 2018;14:14.

http://dx.doi.org/10.1186/s12993-018-0146-7

Fernandez SM, Lewis MC, Pechenino AS, Harburger LL, Orr PT, Gresack JE, et al. Estradiol-Induced Enhancement of Object Memory Consolidation Involves Hippocampal Extracellular Signal-Regulated Kinase Activation and Membrane-Bound Estrogen Receptors. J Neurosci 2008;28:8660- 7. http://dx.doi.org/10.1523/JNEUROSCI.1968-08.2008

Suzuki S, Brown CM, Dela Cruz CD, Yang E, Bridwell DA, Wise PM. Timing of estrogen therapy after ovariectomy dictates the efficacy of its neuroprotective and antiinflammatory actions. Proc Nat Acad Sci 2007;104:6013-8. http://dx.doi.org/10.1073/pnas.0610394104

Luine V, Frankfurt M. Interactions between estradiol, BDNF and dendritic spines in promoting memory. Neuroscience 2013;239:34-45. http://dx.doi.org/10.1016/j.neuroscience.2012.10.019

Camargos AL, Nascimento E. Terapia de reposição hormonal e desempenho cognitivo na terceira idade. Estud Psicol (Campinas) 2009;26:437-43.

http://dx.doi.org/10.1590/S0103- 166X2009000400004

Maki PM. Hormone therapy and cognitive function: Is there a critical period for benefit? Neuroscience 2006;138:1027-30.

http://dx.doi.org/10.1016/j.neuroscience.2006.01.001

Henderson VW. Estrogen-containing hormone therapy and Alzheimer’s disease risk: Understanding discrepant inferences from observational and experimental research. Neuroscience 2016;138:1031-9. http://dx.doi.org/10.1016/j.neuroscience.2005.06.017

Pardini D. Terapia de reposição hormonal na menopausa. Arq Bras Endocrinol Metab 2014;58:172-81.

http://dx.doi.org/10.1590/0004-2730000003044

Daniel JM, Hulst JL, Berbling JL. Estradiol Replacement Enhances Working Memory in Middle-Aged Rats When Initiated Immediately after Ovariectomy But Not after a Long-Term Period of Ovarian Hormone Deprivation. Endocrinology 2006;147:607-14.

http://dx.doi. org/10.1210/en.2005-0998

Shao H, Breitner JCS, Whitmer RA, Wang J, Hayden K, Wengreen H, et al. Hormone therapy and Alzheimer disease dementia: New findings from the Cache County Study. Neurology 2012;79:1846-52.

http://dx.doi.org/10.1212/WNL.0b013e318271f823

Savolainen-Peltonen H, Rahkola-Soisalo P, Hoti F, Vattulainen P, Gissler M, Ylikorkala O, et al. Use of postmenopausal hormone therapy and risk of Alzheimer’s disease in Finland: nationwide case-control study. BMJ 2019;l665. http://dx.doi.org/10.1136/bmj.l665

Henderson VW, St. John JA, Hodis HN, McCleary CA, Stanczyk FZ, Shoupe D, et al. Cognitive effects of estradiol after menopause. Neurology 2016;87:699-708.

http://dx.doi.org/10.1212/WNL.0000000000002980

Fuentes N, Silveyra P. Estrogen receptor signaling mechanisms. In: Advances in Protein Chemistry and Structural Biology. Elsevier; 2019. p.135-70. http://dx.doi.org/10.1016/bs.apcsb.2019.01.001

Heldring N, Pike A, Andersson S, Matthews J, Cheng G, Hartman J, et al. Estrogen Receptors: How Do They Signal and What Are Their Targets. Physiol Rev 2007;87:905-31.

http://dx.doi.org/10.1152/physrev.00026.2006

Pollard KJ, Daniel JM. Nuclear estrogen receptor activation by insulin-like growth factor-1 in Neuro-2A neuroblastoma cells requires endogenous estrogen synthesis and is mediated by mutually repressive MAPK and PI3K cascades. Mol Cell Endocrinol 2019;490:68-79.

http:// dx.doi.org/10.1016/j.mce.2019.04.007

Roskoski R. ERK1/2 MAP kinases: Structure, function, and regulation. Pharmacol Res 2012;66:105-43.

http://dx.doi.org/doi:10.1016/j. phrs.2012.04.005

Dominguez R, Liu R, Baudry M. 17-β-Estradiol-mediated activation of extracellular-signal regulated kinase, phosphatidylinositol 3-kinase/ protein kinase B-Akt and N-methyl-d-aspartate receptor phosphorylation in cortical synaptoneurosomes. J Neurochem 2007;101:232-40.

http:// dx.doi.org/10.1111/j.1471-4159.2006.04360.x

Lee E-R, Kim J-Y, Kang Y-J, Ahn J-Y, Kim J-H, Kim B-W, et al. Interplay between PI3K/Akt and MAPK signaling pathways in DNA- damaging drug-induced apoptosis. Biochim Biophys Acta Mol Cell Res 2006;1763:958-68. http://dx.doi.org/10.1016/j.bbamcr.2006.06.006

Mannella P. Estrogen Receptor Protein Interaction with Phosphatidylinositol 3-Kinase Leads to Activation of Phosphorylated Akt and Extracellular Signal-Regulated Kinase 1/2 in the Same Population of Cortical Neurons: A Unified Mechanism of Estrogen Action. J Neurosci 2006;26:9439-56.

http://dx.doi.org/10.1523/ JNEUROSCI.1443-06.2006

Lehninger AL, Nelson DL, Cox MM. Lehninger Principles of Biochemistry. 6th ed. New York: W.H. Freeman and Company; 2012. p. 433-500.

Martini M, De Santis MC, Braccini L, Gulluni F, Hirsch E. PI3K/ AKT signaling pathway and cancer: an updated review. Ann Med 2014;46:372-83. http://dx.doi.org/10.3109/07853890.2014.912836

Shu Y, Zhang H, Kang T, Zhang J, Yang Y, Liu H, et al. PI3K/Akt Signal Pathway Involved in the Cognitive Impairment Caused by Chronic Cerebral Hypoperfusion in Rats. Ma D, editor. PLoS ONE 2013;8:e81901. http://dx.doi.org/10.1371/journal.pone.0081901

Borrie SC, Brems H, Legius E, Bagni C. Cognitive Dysfunctions in Intellectual Disabilities: The Contributions of the Ras-MAPK and PI3K- AKT-mTOR Pathways. Annu Rev Genom Hum Genet 2017;18:115-42. http://dx.doi.org/10.1146/annurev-genom-091416-035332

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Publicado

2022-05-31

Como Citar

Favaro Bressiani, P., Fernando Weber da Silva, G., & Corrêa, M. da S. (2022). Efeitos do estrogênio sobre a cognição da mulher em menopausa . Revista Neurociências, 30, 1–25. https://doi.org/10.34024/rnc.2022.v30.12006

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Artigos de Revisão
Recebido: 2021-04-26
Aceito: 2022-03-23
Publicado: 2022-05-31

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