Effect of physical exercise on peripheral concentrations of brain-derived neurotrophic factor (BDNF): a literature review
DOI:
https://doi.org/10.34024/rnc.2021.v29.11575Keywords:
BDNF, physical activity, physical training, physical exercise, cognition, humanAbstract
Introduction. Physical exercise (PE) prevents chronic diseases and physical inactivity is harmful to health. The action of the brain-derived neurotrophic factor (BDNF) is among the suggested mechanisms for mediating the benefits of exercise to metabolic and cognitive health. Objective. The aim of the present study was to discuss the BDNF response to physical exercise and the associated clinical outcomes. Method. A literature review was carried out by searching the PUBMED database, with the descriptors ‘BDNF’ and ‘physical activity’. The articles were selected according to the inclusion and exclusion criteria. Results. Analyzes of published studies show that increased concentrations of peripheral BDNF were found in moderate-intensity aerobic exercise/physical training, with heart rate being the most used parameter for prescribing and controlling intensity and walking the most used exercise. In addition, studies with exercise / strength training are still scarce. Conclusion. EF affects peripheral BDNF concentrations, however there is still no consensus in the literature on the prescription of training load. It is not possible to infer that the potential benefits associated with exercise induced BDNF expression are exclusively related to changes in their peripheral concentrations. Further studies are needed to elucidate the BDNF response to EF and its association with metabolic and brain health.
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Copyright (c) 2021 Larissa Ferreira Jacomini Tavares, Marcos Borges Júnior , Paula Luciana Scalzo, Aline Silva de Miranda , Albená Nunes-Silva
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Accepted 2021-09-09
Published 2021-09-27
