Efeito do exercício físico sobre as concentrações periféricas do fator neurotrófico derivado do cérebro (BDNF): uma revisão de literatura





BDNF, atividade física, treinamento físico, exercício físico, cognição, humanos


Introdução. O exercício físico (EF) previne doenças crônicas e a inatividade física é prejudicial à saúde. A ação do fator neurotrófico derivado do cérebro (BDNF) está entre os mecanismos sugeridos para mediação dos benefícios do exercício à saúde metabólica e cognitiva. Objetivo. Discutir a resposta do BDNF ao exercício físico e os desfechos clínicos associados. Método. Foi realizada uma revisão de literatura por meio de pesquisa na base de dados PUBMED, com os descritores ‘BDNF’ e ‘physical activity’. Os artigos foram selecionados conforme critérios de inclusão e exclusão. Resultados. As análises dos trabalhos publicados mostram que o aumento das concentrações de BDNF periférico foram encontrados em exercício/treinamento físico aeróbico de moderada intensidade, sendo a frequência cardíaca o parâmetro mais usado para prescrição e controle da intensidade e a caminhada o exercício mais utilizado. Por outro lado, estudos com exercício/treinamento de força são ainda escassos. Conclusão. O EF afeta as concentrações de BDNF periférico, entretanto ainda não há consenso na literatura sobre a prescrição da carga de treinamento. Não é possível inferir que os potenciais benefícios associados à expressão do BDNF, induzida pelo exercício, estão exclusivamente relacionados às alterações em suas concentrações periféricas. Mais estudos são necessários para elucidar a resposta do BDNF ao EF e sua associação com a saúde metabólica e cerebral.


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Como Citar

Ferreira Jacomini Tavares, L., Borges Júnior , M. ., Luciana Scalzo, P. ., Silva de Miranda , A. ., & Nunes-Silva, A. (2021). Efeito do exercício físico sobre as concentrações periféricas do fator neurotrófico derivado do cérebro (BDNF): uma revisão de literatura . Revista Neurociências, 29, 1–25. https://doi.org/10.34024/rnc.2021.v29.11575



Artigos de Revisão
Recebido: 2020-12-17
Aceito: 2021-09-09
Publicado: 2021-09-27