Efeitos do exercício sobre a regeneração do nervo ciático de ratos Wistar após axonotmese

  • Denis Guilherme Guedert Universidade Regional de Blumenau
  • Edison Sanfelice André Universidade Regional de Blumenau/Departamento de Fisioterapia
Palavras-chave: Lesão nervosa periférica;, axonotmese;, exercício físico;, regeneração nervosa

Resumo

Introdução. Lesões do sistema nervoso periférico são comuns e acarretam perdas tanto sensitivas quanto motoras. Tais lesões interferem na vida do indivíduo devido à diminuição do rendimento profissional. O exercício físico é um dos meios empregados no tratamento das lesões nervosas periféricas. Objetivos. Objetivamos estudar os efeitos do exercício físico (nado forçado) em ratos submetidos a axonotmese. Método. Neste estudo utilizamos quatro grupos: G1 – grupo controle sedentário, G2 – Grupo submetido ao exercício diariamente durante 21 dias iniciando 24 horas após a lesão nervosa, G3 – grupo submetido ao exercício 7 dias após a lesão durante 14 dias consecutivos, G4 – grupo submetido ao exercício 24 horas após a lesão, durante 21 dias, porém em dias alternados. Resultados. Nossos dados apontam para uma melhora funcional observada através do índice funcional do isquiático, incremento na produção de fatores neurotróficos (BDNF e NGF) e diminuição da expressão da enzima iNOS e da citocina TNF–α nos grupos exercitados. Conclusão. O exercício físico na forma em que foi empregado melhorou a função motora e acelerou e a regeneração nervosa periférica. 

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Publicado
2020-11-03
Como Citar
Guedert, D. G., & Sanfelice André, E. (2020). Efeitos do exercício sobre a regeneração do nervo ciático de ratos Wistar após axonotmese. Revista Neurociências, 28, 1-23. https://doi.org/10.34024/rnc.2020.v28.10764
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Artigos Originais