Efectos del ejercicio físico sobre la regeneración nerviosa en ratas Wistar sometidas a axonotmesis del nervio ciático
DOI:
https://doi.org/10.34024/rnc.2020.v28.10764Palabras clave:
Lesión del nervio periférico, axonotmesis, ejercicio físico, nervio ciático, regeneración nerviosaResumen
Introducción. Las lesiones del sistema nervioso periférico son comunes y causan pérdidas tanto sensoriales como motoras. Estas lesiones interfieren en la vida del individuo debido a la disminución del desempeño profesional. El ejercicio físico es uno de los medios utilizados para tratar las lesiones de los nervios periféricos. Objetivo. Estudiar los efectos del ejercicio físico (natación forzada) en ratas sometidas a lesión nerviosa por compresión (axonotmesis). Método. En este estudio utilizamos cuatro grupos: G1 - grupo de control sedentario, G2 - grupo sometido a ejercicio diario durante 21 días a partir de las 24 horas posteriores a la lesión nerviosa, G3 - grupo sometido a ejercicio 7 días después de la lesión durante 14 días consecutivos, G4 - grupo sometido a hacer ejercicio 24 horas después de la lesión, durante 21 días, pero en días alternos. Resultados. Nuestros datos apuntan a una mejora funcional observada a través del índice funcional del ciático, un aumento en la producción de factores neurotróficos (BDNF y NGF) y disminución en la expresión de la enzima iNOS y de la citocina TNF-α en los grupos ejercitados. Conclusión. El ejercicio físico en la forma en que se empleó mejoró la función motora y aceleró la regeneración de los nervios periféricos.
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Referencias
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Aceptado 2020-10-19
Publicado 2020-11-03
