Neurologic manifestations of viral hepatitis
DOI:
https://doi.org/10.34024/rnc.2005.v13.10351Keywords:
Hepatitis, Neurologic ManifestationsAbstract
Infections due to viral hepatites are becoming more prevalent, mainly by hepatites virus A, B and C. Neurologic Manifestations of viral hepatites can be divided in acute and chronic, the former are related to acute encephalitis and meningitis and, rarely, transverse myelitis and Guillain-Barré syndrome. Hepatites B and C virus chronic infections have been related to autoimmune polyneuropathies, cryoglobulinemia and diverse central nervous system symptoms. Specific antiviral therapy can revert these manifestations. In this article we review the main neurologic manifestations of viral hepatites with a clinical focus and therapeutic suggestion.
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24. Ripault MP, Borderie C, Dumas P et al. Peripheral neuropathies and chronic hepatitis C: a frequent association? Gastroenterol Clin Biol 1998;22:891-896.
25. Cacoub P, Poynard T, Ghillani P et al. Extrahepatic manifestations of chronic hepatitis C. MULTIVIRC Group. Multidepartment Virus C. Arthritis Rheum 1999;42:2204-2212.
26. Adartis E, Cacoub P, Musset L et al. Peripheral neuropathies in essential mixed cryoglobulinemia: influence of positive serology for hepatitis C vírus. Rev Med Interne 1993;14:1008.
27. Heckmann JG, Kayser C, Heuss D, Manger B, Blum HE, Neundorfer B. Neurological manifestations of chronic hepatitis C. J Neurol 1999 ;246:486-491.
28. Khella SL, Frost S, Hermann GA et al. Hepatitis C infection, cryoglobulinemia, and vasculitic neuropathy. Treatment with interferon alfa: case report and literature review. Neurology 1995;45:407-411.
29. Apartis E, Leger JM, Musset L et al. Peripheral neuropathy associated with essential mixed cryoglobulinaemia: a role for hepatitis C virus infection? J Neurol Neurosurg Psychiatry 1996;60:661-666.
30. Petty GW, Duffy J, Houston J 3rd. Cerebral ischemia in patients with hepatitis C virus infection and mixed crioglobulinemia. Mayo Clin Proc 1996;71:671-678.
31. Origgi L, Vanoli M, Carbone A, Grasso M, Scorza R. Central nervous system involvement in patients with HCV-related cryoglobulinemia. Am J Med Sci 1998;315:208-210.
32. Bolay H, Soylemezoglu F, Nurlu G, Tuncer S, Varli K. PCR detected hepatitis C virus genome in the brain of a case with progressive encephalomyelitis with rigidity. Clin Neurol Neurosurg 1996;98:305-308.
33. Origgi L, Vanoli M, Lunghi G, Carbone A, Grasso M, Scorza R. Hepatitis C virus genotypes and clinical features in hepatitis C virus-related mixed cryoglobulinemia. Int J Clin Lab Res 1998;28:96-99.
34. Maillefert JF, Farge P, Gazet-Maillefert MP, Tavernier C. Mental nerve neuropathy as a result of hepatitis B vaccination. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997;83:663-664.
35. Kakar A, Sethi PK. Guillain Barre syndrome associated with hepatitis B vaccination. Indian J Pediatr 1997;64:710-712.
36. Shaw FE Jr, Graham DJ, Guess HA et al. Postmarketing surveillance for neurologic adverse events reported after hepatitis B vaccination. Experience of the first three years. Am J Epidemiol 1988;127:337-352.
37. Piyasirisilp S, Hemachudha T. Neurological adverse events associated with vaccination. Curr Opin Neurol 2002;15:333-338.
38. Hoofnagle JH, Di Bisceglie AM. The Treatment of Chronic Viral Hepatitis. NEJM 1997;336:347-356.
39. H Köller, BC Kieseier, S Jander, H-P Hartung. Medical Progress: Chronic Inflammatory Demyelinating Polyneuropathy. NEJM 2005;352:1343-1356. 40. Saperstein DS, Katz JS, Amato AA, Barohn RJ. Clinical spectrum of chronic acquired demyelinating polyneuropathies. Muscle Nerve 2001;24:311-324.
41. Corcia P, Barbereau D, Guennoc AM, de Toffol B, Bacq Y. Improvement of a CIDP associated with hepatitis C virus infection using antiviral therapy. Neurology 2004;63:179-180.
42. Boonyapisit K, Katirji B. Severe exacerbation of hepatitis C-associated vasculitic neuropathy following treatment with interferon alpha: a case report and literature review. Muscle Nerve 2002 ;25:909-913.
2. Cohen P. Les manifestations extra-hépatiques du virus de l’hepatite C. Press Med 2000;29:209-214.
3. Mtsushima K, Niwa K, Fujita H, Yamamoto M, Shinohara Y. Acute hepatitis A (HA) presenting findings of meningoencephalitis. Rinsho Shinkeigaku 1992;32:441-443.
4. Breningstall GN, Belani KK. Acute transverse myelitis and brainstem encephalitis associated with hepatitis A infection. Pediatr Neurol 1995;12:169-171.
5. Fujita H, Chuganji Y, Yaginuma M, Momoi M, Tanaka T. Case report: acute encephalitis immediately prior to acute onset of hepatitis C virus infection. J Gastroenterol Hepatol 1999;14:1129-1131.
6. Berman M, Feldman S, Alter M, Zilber N, Kahana E. Acute transverse myelitis: incidence and etiologic considerations. Neurology 1981;31:966-971.
7. Filippini D, Colombo F, Jann S, Cornero R, Canesi B. Central nervous system involvement in patients with HCV-rela
ted cryoglobulinemia: literature review and a case report. Reumatismo 2002;54:150-155.
8. Tembl JI, Ferrer JM, Sevilla MT, Lago A, Mayordomo F, Vilchez JJ. Neurologic complications associated with hepatitis C virus infection. Neurology 1999;53:861.
9. Hahn AF. Guilain-Barré syndrome. Lancet 1998;352:635-641.
10. Oomes PG, van der Meche FG, Kleyweg RP. Liver function disturbances in Guillain-Barre syndrome: a prospective longitudinal study in 100 patients. Dutch Guillain-Barre Study Group. Neurology 1996;46:96-100.
11. Bosch VV, Dowling PC, Cook SD. Hepatitis A virus immunoglobulin M antibody in acute neurological disease. Ann Neurol 1983;14:685-687.
12. Porst H, Hentschel R, Sauermann W, Lehmann HU, Lohmann J, Schentke KU. Guillain-Barre polyradiculitis in acute viral hepatitis type B—case report. Dtsch Z Verdau Stoffwechselkr 1983;43:146-149.
13. Sood A, Midha V, Sood N. Guillain-Barre syndrome with acute hepatitis E. Am J Gastroenterol 2000;95:3667-3668.
14. Lin SM, Ryu SJ, Liaw YF. Guillain-Barre syndrome associated with acute delta hepatitis virus superinfection. J Med Virol 1989;28:144-145.
15. World health Organization. at www.who.int/emc-documents/hepatitis/docs/ whocdscsrlyo20022/disease/ extrahepatic_manifestations.html. acessado em 1o de maio de 2005. 16. Trepo C, Guillevin L. Polyarteritis nodosa and extrahepatic manifestations of HBV infection: the case against autoimmune intervention in pathogenesis. J Autoimmun 2001;16:269-274.
17. Godeau P, Guillevin L, Bletry O, Wechsler B. Periarteritis nodosa associated with hepatitis B virus. 42 cases (author’s transl). Nouv Presse Med 1981;10:1289-1292.
18. McMahon BJ, Alberts SR, Wainwright RB, Bulkow L, Lanier AP. Hepatitis B-related sequelae. Prospective study in 1400 hepatitis B surface antigen-positive Alaska native carriers. Arch Intern Med 1990;150:1051-1054.
19. Galli M, Monti G, Invernizzi F et al. Hepatitis B virus-related markers in secondary and in essential mixed cryoglobulinemias: a multicentric study of 596 cases. The Italian Group for the Study of Cryoglobulinemias (GISC). Ann Ital Med Int 1992;7:209-214.
20. Levo Y, Gorevic PD, Kassab HJ, Zucker-Franklin D, Franklin EC. Association between hepatitis B virus and essential mixed cryoglobulinemia. N Engl J Med 1977;296:1501-1504.
21. Kamper AM, Van Der Merwe CF, Aspinall S. Chronic hepatitis B and neurogenic muscle disease: case report. East Afr Med J 1998;75:667-668. 22. Han HF, Wu JC, Huo TI et al. Chronic hepatitis B exacerbated by Guillain-Barre syndrome: a report of two cases. Zhonghua Yi Xue Za Zhi (Taipei) 1999;62:652-656.
23. Awada A, Sullivan S, Palkar V, Sbeih F, Naufal R, Al Rajeh S. Brain magnetic resonance imaging in non-alcoholic cirrhosis. Eur J Radiol 1995;21:84-88.
24. Ripault MP, Borderie C, Dumas P et al. Peripheral neuropathies and chronic hepatitis C: a frequent association? Gastroenterol Clin Biol 1998;22:891-896.
25. Cacoub P, Poynard T, Ghillani P et al. Extrahepatic manifestations of chronic hepatitis C. MULTIVIRC Group. Multidepartment Virus C. Arthritis Rheum 1999;42:2204-2212.
26. Adartis E, Cacoub P, Musset L et al. Peripheral neuropathies in essential mixed cryoglobulinemia: influence of positive serology for hepatitis C vírus. Rev Med Interne 1993;14:1008.
27. Heckmann JG, Kayser C, Heuss D, Manger B, Blum HE, Neundorfer B. Neurological manifestations of chronic hepatitis C. J Neurol 1999 ;246:486-491.
28. Khella SL, Frost S, Hermann GA et al. Hepatitis C infection, cryoglobulinemia, and vasculitic neuropathy. Treatment with interferon alfa: case report and literature review. Neurology 1995;45:407-411.
29. Apartis E, Leger JM, Musset L et al. Peripheral neuropathy associated with essential mixed cryoglobulinaemia: a role for hepatitis C virus infection? J Neurol Neurosurg Psychiatry 1996;60:661-666.
30. Petty GW, Duffy J, Houston J 3rd. Cerebral ischemia in patients with hepatitis C virus infection and mixed crioglobulinemia. Mayo Clin Proc 1996;71:671-678.
31. Origgi L, Vanoli M, Carbone A, Grasso M, Scorza R. Central nervous system involvement in patients with HCV-related cryoglobulinemia. Am J Med Sci 1998;315:208-210.
32. Bolay H, Soylemezoglu F, Nurlu G, Tuncer S, Varli K. PCR detected hepatitis C virus genome in the brain of a case with progressive encephalomyelitis with rigidity. Clin Neurol Neurosurg 1996;98:305-308.
33. Origgi L, Vanoli M, Lunghi G, Carbone A, Grasso M, Scorza R. Hepatitis C virus genotypes and clinical features in hepatitis C virus-related mixed cryoglobulinemia. Int J Clin Lab Res 1998;28:96-99.
34. Maillefert JF, Farge P, Gazet-Maillefert MP, Tavernier C. Mental nerve neuropathy as a result of hepatitis B vaccination. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997;83:663-664.
35. Kakar A, Sethi PK. Guillain Barre syndrome associated with hepatitis B vaccination. Indian J Pediatr 1997;64:710-712.
36. Shaw FE Jr, Graham DJ, Guess HA et al. Postmarketing surveillance for neurologic adverse events reported after hepatitis B vaccination. Experience of the first three years. Am J Epidemiol 1988;127:337-352.
37. Piyasirisilp S, Hemachudha T. Neurological adverse events associated with vaccination. Curr Opin Neurol 2002;15:333-338.
38. Hoofnagle JH, Di Bisceglie AM. The Treatment of Chronic Viral Hepatitis. NEJM 1997;336:347-356.
39. H Köller, BC Kieseier, S Jander, H-P Hartung. Medical Progress: Chronic Inflammatory Demyelinating Polyneuropathy. NEJM 2005;352:1343-1356. 40. Saperstein DS, Katz JS, Amato AA, Barohn RJ. Clinical spectrum of chronic acquired demyelinating polyneuropathies. Muscle Nerve 2001;24:311-324.
41. Corcia P, Barbereau D, Guennoc AM, de Toffol B, Bacq Y. Improvement of a CIDP associated with hepatitis C virus infection using antiviral therapy. Neurology 2004;63:179-180.
42. Boonyapisit K, Katirji B. Severe exacerbation of hepatitis C-associated vasculitic neuropathy following treatment with interferon alpha: a case report and literature review. Muscle Nerve 2002 ;25:909-913.
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2005-09-30
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Bichuetti DB, Oliveira ASB. Neurologic manifestations of viral hepatitis . Rev Neurocienc [Internet]. 2005 Sep. 30 [cited 2025 Dec. 13];13(3):133-7. Available from: https://periodicos.unifesp.br/index.php/neurociencias/article/view/10351
