Acupuncture in Parkinson Disease: experimental and clinical trials review
DOI:
https://doi.org/10.34024/rnc.2007.v15.10280Keywords:
Acupuncture Therapy, Parkinson Disease, Neurodegenerative DiseasesAbstract
Introduction. Parkinson’s Disease (PD) is one of the most common neurodegenerative diseases. Although clinical treatments based in western medicine have advanced in the last years, they are not capable to avoid the disease progression and its symptons. Recently, the interest in Traditional Chinese Medicine (TCM) has increased in scientific field and in general population, and it is cogitated that TCM has therapeutic properties in neurodegenerative diseases. Objective. To describe the main results of clinical and experimental trial which have analyzed the effects of acupuncture in PD. Method. Narrative literature review. Discussion. Experimental trials have indicated benefic effects of acupuncture in PD, like neuroprotection, neurotrofic stimulation, immunologic protection and neurotransmitters function modulation. Clinical trials have indicated potential benefits in motricity, sleep, quality of life and medication side effects. Conclusions. There is a lack of conclusive data about the acupuncture effectivity in PD, mainly about its physiologic mechanism under therapeutic effects. The use of acupuncture in PD can be considered as a complement in western treatment.
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References
2. Pankratz N, Foroud T. Genetics of Parkinson Disease. NeuroRx 2004;1(2):235-242.
3. Clarke CE. Neuroprotection and Pharmacotherapy for motor symptons in Parkinson´s disease. Lancet Neurol 2004;3:466-574.
4. Fahn S, Sulzer D. Neurodegeneration and Neuroprotection in Parkinson Disease. NeuroRx 2004;1(1):139-154.
5. Palmeira G. A acupuntura no ocidente. Cad Saúde Pública 1990.6(2):117-128.
6. Rajendran PR, Thompson RE, Reich SG. The use of alternative therapies by patients with Parkinson´s disease. Neurology 2001;57(1):790-794.
7. Tan LCS, Lau PN, Jamora RDG, Chan ESY. Use of complementary therapies in patient with Parkinson´s disease in Singapore. Mov Disord 2006.21(1):86-89.
8. Ross J. ZANG FU: Sistemas de Órgãos e Vísceras da Medicina Tradicional Chinesa. São Paulo: ROCA, 1994, 267p.
9. Rabinstein AA, Shulman LM. Acupuncture in clinical neurology. The Neurologist 2003;9(3):137-148.
10. Shulman LM, Wen X, Weiner WJ, Bateman D, Minagar A, Duncan R, et al. Acupuncture Therapy for the Symptons of Parkinson´s Disease. Mov Disord 2002;17(4):799-802.
11. Seki T, Kurusu M, Arai H, Sasaki H. Acupuncture for gait disorders in the elderly. J Am Geriatr Soc 2004;52(4):643-644.
12. Cristian A, Katz M, Cutrone E, Walker RH. Evaluation of Acupuncture in the Treatment of Parkinson´s Disease: A Double-Blind Pilot Study. Mov Disord 2005;20(9):1185-1188.
13. Zhuang X, Wang L. Acupuncture treatment of Parkinson’s Disease- a report of 29 cases. J Tradit Chin Med 2000;20:265–267.
14. Lee A, Done ML. Stimulation of the wrist acupuncture point P6 for preventing postoperative nausea and vomiting (Cochrane Review). In: The Cochrane Library 2005. 2. Oxford: Update Software.
15. Jankovic J. Levodopa strengths and weakness. Neurology 2002;58(suppl 1):19-32.
16. Yansong L, Xiantong L. Comparative study of D2 receptors and dopamine content in striatum before and after electro-acupuncture treatment in rats. Chin Med J 2000;113(5):408-411.
17. Zhu W, Xi G, Ju J. Effect of acupuncture and Chinese medicine treatment on brain dopamine level of MPTP-lesioned C57BL mice. Zhen Ci Yan Jiu [Tradução] 1996;21(4):46-49.
18. Chang YH, Hsieh MT, Cheng JT. Increase of locomotor activity by acupuncture on Bai-Hui point in rats. Neurosci Lett 1996;211:121-124.
19. Yano T, Kato B, Fukuda F, Shinbara H, Yoshimoto K, Ozaki A, et al. Alterations in the Function of Cerebral Dopaminergic and Serotonergic Systems Following Electroacupuncture and Moxibustion Applications: Possible Correlates with Their Antistress and Psychosomatic Actions. Neurochem Res 2004;28(1):283-293.
20. Ma J, Zhu SX. Effect of electroacupuncture on anti-oxidase in mesencephalic substantia nigra in rats with Parkinson disease. Chin J Clin Rehabil 2005;9(5):120-121.
21. Park HIJ, Lim S, Joo WS, Yin CS, Lee HS, Lee HJ, et al. Acupuncture prevents 6-hydroxydopamine-induced neuronal death in the nigrostriatal dopaminergic system in the rat Parkinson’s disease model. Exp Neurol 2003;180(1):148–157.
22. Liang XB, Liu XY, Li FQ, Luo Y, Lu J, Zhang WM, et al. Longterm high-frequency electro-acupuncture stimulation prevents neuronal degeneration and up-regulates BDNF mRNA in the substantia nigra and ventral tegmental area following medial forebrain bundle axotomy. Mol Brain Res 2002;108(1-2):51-59.
23. Liu XY, Zhou HF, Pan YL, Liang XB, Niu DB, Xue B, et al. Electro-acupuncture stimulation protects dopaminergic neurons from inflammation-mediated damage in medial forebrain bundle-transected rats. Exp Neurol 2004;189(1):189-196.
24. Luo ZD, Yin LH, Chen XH, Tang CZ, Lin JQ. Effect of acupuncture on blood T lymphocyte subpopulation in rat model with Parkinson´s disease. Chin J Clin Rehabil 2004;8(10):1904-1905.
