Evaluation of Receptor 5HT3 In the Modulation of Analgesia Induced by TENS

Authors

  • Rafael Rodrigues de Souza Farmacêutico, pós-graduando em Fisiologia pela Universidade Federal do Triângulo Mineiro – UFTM, Uberaba-MG, Brasil
  • Thiago Henrique Ferreira Vasconcellos Psicólogo, pós-graduando do Departamento de Psicologia da Universidade Federal de Minas Gerais – UFMG, Belo Horizonte-MG, Brasil.
  • Thais Cristina Teixeira Gonçalves Graduanda em Medicina pelo Centro Universitário de Patos de Minas – UNIPAM – Patos de Minas-MG, Brasil.
  • Dulcinéa Gonçalves Teixeira Farmacêutica, Doutora, Professora e coordenadora do Laboratório de Anatomia Humana do Centro Universitário de Patos de Minas – UNIPAM, Patos de Minas-MG, Brasil.
  • Célio Marcos dos Reis Ferreira Fisioterapeuta, Doutor, Professor do departamento de Fisioterapia do curso de Fisioterapia da Universidade Federal dos Vales do Jequitinhonha e Mucuri – UFVJM, Diamantina-MG, Brasil.

DOI:

https://doi.org/10.34024/rnc.2013.v21.8142

Keywords:

Analgesia, Transcutaneous Electric Nerve Stimulation – TENS, Serotonin Agents

Abstract

Objective. Verify the participation of the serotoninergic pathway and the 5HT3 receptor in modulation of TENS induced analgesia. Method. Male wistar rats were used weighing from 180 to 200g, which were pretreated with ondansetron (OND) 3mg/kg and physi­ologic saline before the therapy with TENS which lasted 30 minutes. Right after the end of the electric stimulation, the nociceptive thresh­olds were evaluated up to 60 minutes. Results. We observed that the serotoninergic pathway and the 5HT3 receptors take part at the modulation of the TENS induced analgesia, once the OND admin­istration antagonized the antinotiception of TENS in both high and low frequency (p<0,05). We also analyzed that high frequency TENS provided a stronger analgesia which also lasted longer than low fre­quency TENS. Conclusion. We can conclude that the serotoninergic pathway and the 5HT3 receptors are involved in the modulation of TENS induced analgesia.

References

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Published

2013-12-31

Issue

Vol. 21 No. 4 (2013)

Section

Artigos Originais

How to Cite

1.
Souza RR de, Vasconcellos THF, Gonçalves TCT, Teixeira DG, Ferreira CM dos R. Evaluation of Receptor 5HT3 In the Modulation of Analgesia Induced by TENS. Rev Neurocienc [Internet]. 2013 Dec. 31 [cited 2026 Oct. 17];21(4):537-41. Available from: https://periodicos.unifesp.br/neurociencias/article/view/8142