Interações moleculares dos RNAs longos não codificantes na encefalopatia hepática associada à cirrose: uma revisão sistemática
DOI:
https://doi.org/10.34024/rnc.2025.v33.20460Palavras-chave:
encefalopatia hepática, lncRNA, miRNA, mRNA, lncRNA-miRNA-mRNAResumo
Introdução. A encefalopatia hepática (EH) é uma síndrome neurológica complexa e potencialmente reversível, decorrente de doenças hepáticas agudas ou crônicas, caracterizada por alterações neuropsiquiátricas, cognitivas, motoras e de coordenação neuromuscular. Os estudos sobre o papel dos RNAs longos não codificantes (lncRNAs) na encefalopatia ainda são limitados. Portanto, está revisão sistemática descreve o papel dos lncRNAs nas diferentes vias de sinalização envolvidas na EH em pacientes cirróticos. Método. As bases de dados PubMed, Web of Science e LILACS foram utilizadas para identificar os estudos. Foram incluídos estudos com camundongos e/ou pacientes cirróticos com EH que avaliavam a expressão de lncRNAs e seus mecanismos de interação. Resultados. Dos seis estudos incluídos, 11 lncRNAs foram associados à EH (SIX3OS, lnc240, AL137857.1, lnc-FAM84B-8, lnc-SAMD3-1, ZFAS1, GAS5, uc007pjf.1, ENSMUST00000167589, uc007hha.1, ENSMUST00000124047). Três estudos foram realizados com pacientes cirróticos com EH, enquanto outros três utilizaram camundongos. Os resultados variaram entre expressão e silenciamento associados a mecanismos regulatórios. Na rede de interação entre as vias lnc240/miR-1264-5p/MEF2C, foi indicado que o lnc240 pode regular a expressão do MEF2C por meio do miR-1264-5p, afetando a plasticidade sináptica hipocampal. O silenciamento de SIX3OS1 aumentou a expressão de miR-743b-3p, reduziu os níveis de AQP1 e atenuou o desenvolvimento anormal de espinhas dendríticas induzido pela hiperamonemia, reforçando a relevância dessa interação. Conclusão. Esta é a primeira revisão sistemática a avaliar o papel dos lncRNAs e de suas redes de interação na EH em pacientes cirróticos. Diversos lncRNAs regulam vias sendo expressos ou silenciados, influenciando miRNAs e mRNAs.
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Copyright (c) 2025 Liebert Bernardes Carvalho, Alex Camargo Coque, Lucas Maruchi Delapena-Silva, Camila Lopes Ferreira, Maria Martha Bernardi, Rodrigo Augusto Foganholi da Silva
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Aceito 2025-11-06
Publicado 2025-12-18
