Fasciculação
DOI:
https://doi.org/10.34024/rnc.2000.v8.8955Palavras-chave:
Fasciculação, doença de neurônio motorResumo
Fasciculações são resultantes de descargas espontâneas de unidades motoras, mas o local de origem dessas descargas e seu mecanismo fisiológico permanecem incertos e controversos. Muitos autores têm defendido uma origem central para essas descargas anormais nas células do corno anterior. Entretanto, a maioria das evidências favorece a origem periférica no terminal intramuscular do nervo motor. As fasciculações são observadas em pacientes com doenças neurológicas e em pessoas sadias. A gabapentina tem sido considerada uma alternativa segura para o tratamento das fasciculações.
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Howard RS, Murray NMF. Surface EMG in the recording of fasciculations. Muscle & Nerve, 15:1240-5, 1992.
Mitsikostas DD, Karandreas N et al. Fasciculation potencials in healthy people. Muscle & Nerve, 21(4):533-5, 1998.
Blexrud MD, Windebank AJ et al. Long-term folow-up of 121 patients with benign fasciculations. Ann Neurol, 34 (4):622-5, 1993.
Denny-Brown D & Pennybacker JB. Fibrilation and fasciculation in voluntary muscles. Brain, 61:311-334, 1938.
Eisen A, Stewart H. Not-so-benign fasciculation. Ann Neurol, 35(3):375-6, 1994.
Fleet WS, Watson RT. From benign fasciculations and cramps to motor neuron disease. Neurology, 36(7):997-8, 1986.
Russel CK, Odom G et al. Physiological and chemical studies of neuromuscular disorders. Trans Am Neurol Assoc, 64:120-124, 1938.
Wettstein A.The origin of fasciculations in motoneuron disease. Ann Neurol, 5:295, 1979.9. Desai J, Swash M. Fasciculations: what do we know of their significance? J Neurol Sci, 152(suppl 1):S43-8, 1997.
Masland RL & Wigiton RS. Nerve activity accompanying fasciculation produced by prostigmin. J Neurophysiol, 3:269-275, 1940.
Forster FM & Alpers BJ. Site of origin of fasciculations in voluntary muscle. Arch Neurol Psychiatry, 51:264-267, 1944.
Forster FM, Borkowski WJ et al. Effects of denervation on fasciculations in human muscle. Relation of fibrillations to fasciculations. Arch Neurol Psychiatry, 56:276-283, 1946.
Layzer RB. The origin of muscle fasciculations and cramps. Muscle & Nerve, 17:1243-9, 1946.
Roth G. The origin of fasciculations. Ann Neurol, 12:542-7, 1982.
Conradi S, Grimby L et al. Pathophysiology of fasciculations in ALS as studied by eletromyography of single motor units. Muscle & Nerve, 5:202-8, 1982.
Carvalho M, Swash M. Fasciculation potencials: a study of amyotrophic lateral sclerosis and other neurogenic disorders. Muscle & Nerve, 21(3):336-44, 1998.
Serrao M, Cardinali P et al. A case of myokimia-cramp syndrome successfully treated with gabapentin. Acta Neurol Scand, 98(6):458-60, 1998.
Romano JG. Reduction of fasciculations in patients with amyotrophic lateral sclerosis with the use of gabapentin. Arch Neurol, 53(8):716, 1996.
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Publicado: 2000-03-31